全文获取类型
收费全文 | 2320篇 |
免费 | 142篇 |
国内免费 | 52篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 100篇 |
妇产科学 | 70篇 |
基础医学 | 339篇 |
口腔科学 | 42篇 |
临床医学 | 261篇 |
内科学 | 524篇 |
皮肤病学 | 40篇 |
神经病学 | 191篇 |
特种医学 | 148篇 |
外科学 | 144篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 196篇 |
眼科学 | 33篇 |
药学 | 208篇 |
中国医学 | 13篇 |
肿瘤学 | 179篇 |
出版年
2024年 | 7篇 |
2023年 | 19篇 |
2022年 | 40篇 |
2021年 | 81篇 |
2020年 | 47篇 |
2019年 | 75篇 |
2018年 | 76篇 |
2017年 | 41篇 |
2016年 | 56篇 |
2015年 | 67篇 |
2014年 | 102篇 |
2013年 | 124篇 |
2012年 | 157篇 |
2011年 | 136篇 |
2010年 | 104篇 |
2009年 | 100篇 |
2008年 | 135篇 |
2007年 | 137篇 |
2006年 | 111篇 |
2005年 | 101篇 |
2004年 | 97篇 |
2003年 | 77篇 |
2002年 | 70篇 |
2001年 | 12篇 |
2000年 | 15篇 |
1999年 | 22篇 |
1998年 | 52篇 |
1997年 | 40篇 |
1996年 | 43篇 |
1995年 | 34篇 |
1994年 | 23篇 |
1993年 | 29篇 |
1992年 | 18篇 |
1991年 | 14篇 |
1990年 | 17篇 |
1989年 | 33篇 |
1988年 | 35篇 |
1987年 | 24篇 |
1986年 | 22篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 11篇 |
1982年 | 14篇 |
1981年 | 7篇 |
1980年 | 12篇 |
1978年 | 7篇 |
1977年 | 12篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1924年 | 4篇 |
排序方式: 共有2514条查询结果,搜索用时 15 毫秒
1.
2.
3.
Angelo M. Carella Sandro Nati Paolo Carlier Daniela Pierluigi Domenico Giordano Angela Congiu Gino Santini Daniele Scarpati Salvina Barra Renzo Corvo Vito Vitale Maria R. Raffo Raffaella Cerri Marco Risso Mauro Spriano Renato Vimercati Ester Pungolino Andrea Bacigalupo Eugenio Damasio 《Leukemia & lymphoma》1991,5(1):43-47
Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed included cyclophosphamide and total body irradiation, followed by the administration of unpurged ABMT. The median time from diagnosis to transplant was 7 months (3-15 months), and the median time from complete remission to ABMT was 4 months (range 3-9 months). Twenty-two (51%) patients remain in complete remission 6-81 months (median 24 months) after ABMT.
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
4.
5.
We used arthrotomography to study the glenoid labrum in 114 patients. Sixty-nine of the patients had anatomic instability of the shoulder (including recurrent dislocation and subluxation of the shoulder), and 45 patients had functional instability of the shoulder (denoted by chronic pain, clicking of the joint, and the sensation that an unstable condition exists without the objective signs of it). Labral tears were revealed arthrotomographically in 86% of the patients with anatomic instability, while only 40% of the patients with functional instability had labral abnormalities, and these were primarily of minor severity. Fifty-six patients (44 of whom had anatomic instability; 12, functional instability) required surgery. The surgical findings were correlated with the arthrotomographic findings, and no false-positive results were revealed. However, arthrotomography demonstrated only part of the pathologic condition of two patients. These results confirm that there is a strong correlation between labral pathologic conditions and anatomic instability of the shoulder. Arthrotomographic studies have a great impact on the selection of therapy in cases of both anatomic and functional instability of the shoulder. 相似文献
6.
7.
Debora Steiner Tomer Avidor-Reiss Ester Schallmach Daniella Saya Zvi Vogel 《Journal of molecular neuroscience : MN》1996,27(2):195-203
It was shown previously that chronic exposure to opiate agonists increases adenylyl cyclase (AC) activity, a phenomenon termed
AC superactivation (or supersensitization). More recently, we showed that acute Gi/o-coupled receptor activation inhibits the activity of several AC isozymes, including Ca2+/calmodulin-stimulated AC-I and -VIII, whereas chronic receptor activation induces their superactivation. Here, we report
that both acute μ-opioid receptor-induced inhibition and chronic induced superactivation of AC-I and -VIII are pertussis toxin
sensitive. In addition, we show that proteins that interfere with the activity of {ie195-2} subunits ({ie195-3} scavengers)
strongly attenuate the acute inhibition of AC-I and -VIII and the superactivation of AC-I, and abolish the superactivation
of AC-VIII. Based on these results, we suggest that {ie195-4} is involved in the acute inhibition and chronic agonist-induced
superactivation of AC types I and VIII. 相似文献
8.
Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group 总被引:5,自引:0,他引:5
Haines JL; Terwedow HA; Burgess K; Pericak-Vance MA; Rimmler JB; Martin ER; Oksenberg JR; Lincoln R; Zhang DY; Banatao DR; Gatto N; Goodkin DE; Hauser SL 《Human molecular genetics》1998,7(8):1229-1234
Multiple sclerosis (MS) is a demyelinating autoimmune disease of the
central nervous system. While its etiology is not well understood, genetic
factors are clearly involved. Until recently, most genetic studies in MS
have been association studies using the case-control design testing
specific candidate genes and studying only sporadic cases. The only
consistently replicated finding has been an association with the HLA-DR2
allele within the major histocompatibility complex (MHC) on chromosome 6.
Using the genetic linkage design, however, evidence for and against linkage
of the MHC to MS has been found, fostering suggestions that sporadic and
familial MS have different etiologies. Most recently, two of four genomic
screens demonstrated linkage to the MHC, although specific allelic
associations were not tested. Here, a dataset of 98 multiplex families was
studied to test for an association to the HLA-DR2 allele in familial MS and
to determine if genetic linkage to the MHC was due solely to such an
association. Three highly polymorphic markers (HLA-DR, D6S273 and TNFbeta)
in the MHC demonstrated strong genetic linkage (parametric lod scores of
4.60, 2.20 and 1.24, respectively) and a specific association with the
HLA-DR2 allele was confirmed (TDT; P < 0.001). Stratifying the results
by HLA-DR2 status showed that the linkage results were limited to families
segregating HLA-DR2 alleles. These results demonstrate that genetic linkage
to the MHC can be explained by the HLA-DR2 allelic association. They also
indicate that sporadic and familial MS share a common genetic
susceptibility. In addition, preliminary calculations suggest that the MHC
explains between 17 and 62% of the genetic etiology of MS. This
heterogeneity is also supported by the minority of families showing no
linkage or association with loci within the MHC.
相似文献
9.
Helen He Ester Del Duca Aisleen Diaz Hyun Je Kim Jesús Gay-Mimbrera Ning Zhang Jianni Wu Jessica Beaziz Yeriel Estrada James G. Krueger Ana B. Pavel Juan Ruano Emma Guttman-Yassky 《The Journal of allergy and clinical immunology》2021,147(4):1369-1380
- Download : Download high-res image (227KB)
- Download : Download full-size image