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排序方式: 共有458条查询结果,搜索用时 15 毫秒
1.
Radhouene Doggui Hanin Al-Jawaldeh Jalila El Ati Rawhieh Barham Lara Nasreddine Nawal Alqaoud Hassan Aguenaou Laila El Ammari Jana Jabbour Ayoub Al-Jawaldeh 《Nutrients》2021,13(5)
The Eastern Mediterranean Region (EMR) is experiencing a nutrition transition, characterized by the emergence of overnutrition and micro-nutrient deficiencies. No previous study has comparatively examined nutrient intake in adults across countries in the EMR. This review examined the adequacy of nutrients in adults living in the EMR. Moreover, it analyzed the food balance sheets (FBS) for 1961–2018 to identify the trajectory of energy supply from macro-nutrients in the EMR. A systematic search was conducted from January 2012 to September 2020. Only observational studies were retained with a random sampling design. An assessment of the methodological quality was conducted. Levels of nutrient daily intake and their adequacy compared to the daily reference intake of the Institute of Medicine were reported across the region. No studies were identified for half of the region’s countries. Although nutrient energy intake was satisfactory overall, fat and carbohydrate intake were high. Intake of vitamin D, calcium, potassium, zinc, and magnesium were below that recommended. The analysis of the FBS data allowed for the identification of four linear patterns of trajectories, with countries in the EMR best fitting the ‘high-energy-supply from carbohydrate’ group. This systematic review warrants multi-sectorial commitment to optimize nutrient intake. 相似文献
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Nawal H. Almohammadi 《Saudi medical journal》2022,43(3):283
Objectives:To describe the frequency and spectrum of different types of gynecological malignancies (malignant tumors of the female genital tract) and to characterize the pattern of gynecological neoplasms in different age groups in Al-Madinah Al-Munawarah, Saudi Arabia.Methods:This 6-year retrospective-design research was carried out on different age groups in Al-Madinah Al-Munawarah region, from June 2015 until June 2021. The patients’ information of all 200 specimens, including age, nationality, tumor site, and pathological disorders was obtained from the Maternity and Children Hospital, Al-Madinah Al-Munawarah.Results:Endometrial cancer was the most common malignancy for women of 31 years and above (69.0%). Tumors of the uterine corpus were mostly epithelial (86.7%) and possessed an endometrioid carcinoma histology (90.6%). There was only a small decline in gynecological cancer incidences in Al-Madinah Al-Munawarah over the past 6 years.Conclusion:Most of the cancer incidences, regardless of the pathological diagnosis, either increased or remained unchanged over time, is a possible indication of the current state of health programs and information available to the citizens in Al-Madinah Al-Munawarah. Further studies exploring the economic background of diagnosed patients may be of interest to future research. 相似文献
4.
Khushnooma Y. Italia Farah F. Jijina Dipty Jain Rashid Merchant Anita H. Nadkarni Malay Mukherjee Kanjaksha Ghosh Roshan B. Colah 《Clinical biochemistry》2010,43(16-17):1329-1332
ObjectivesHydroxyurea is known to reduce ineffective erythropoiesis and thereby hemolysis leading to a reduction in bilirubin levels in patients with hemoglobinopathies. However, the effect of hydroxyurea on hyperbilirubinemia in relation to the UGT1A1 gene promoter polymorphism is not known in Indian patients with different hemoglobinopathies.Design and methodsWe studied 112 patients (77 sickle cell anemia, 22 β-thalassemia intermedia and 13 HbE-β-thalassemia) who were on hydroxyurea therapy for 2 years for their response towards hyperbilirubinemia associated with UGT1A1 promoter polymorphism.ResultsThe patients with (TA)7/(TA)7 repeats had significantly higher serum bilirubin levels than those with (TA)6/(TA)6 repeats in all the groups and the reduction in serum bilirubin after hydroxyurea therapy was still higher among patients with (TA)7/(TA)7 repeats when compared with (TA)6/(TA)6 repeats.ConclusionsHigher bilirubin levels were associated with the (TA)7/(TA)7 sequence however they did not come down to normal levels after hydroxyurea therapy. 相似文献
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Extending the mutation spectrum for Galloway–Mowat syndrome to include homozygous missense mutations in the WDR73 gene
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8.
Christian Staufner Martin Lindner Carlo Dionisi-Vici Peter Freisinger Dries Dobbelaere Claire Douillard Nawal Makhseed Beate K. Straub Kimia Kahrizi Diana Ballhausen Giancarlo la Marca Stefan Kölker Dorothea Haas Georg F. Hoffmann Sarah C. Grünert Henk J. Blom 《Journal of inherited metabolic disease》2016,39(2):273-283
Background
Adenosine kinase deficiency is a recently described defect affecting methionine metabolism with a severe clinical phenotype comprising mainly neurological and hepatic impairment and dysmorphism.Methods
Clinical data of 11 additional patients from eight families with adenosine kinase deficiency were gathered through a retrospective questionnaire. Two liver biopsies of one patient were systematically evaluated.Results
The main clinical symptoms are mild to severe liver dysfunction with neonatal onset, muscular hypotonia, global developmental retardation and dysmorphism (especially frontal bossing). Hepatic involvement is not a constant finding. Most patients have epilepsy and recurrent hypoglycemia due to hyperinsulinism. Major biochemical findings are intermittent hypermethioninemia, increased S-adenosylmethionine and S-adenosylhomocysteine in plasma and increased adenosine in urine. S-adenosylmethionine and S-adenosylhomocysteine are the most reliable biochemical markers. The major histological finding was pronounced microvesicular hepatic steatosis. Therapeutic trials with a methionine restricted diet indicate a potential beneficial effect on biochemical and clinical parameters in four patients and hyperinsulinism was responsive to diazoxide in two patients.Conclusion
Adenosine kinase deficiency is a severe inborn error at the cross-road of methionine and adenosine metabolism that mainly causes dysmorphism, brain and liver symptoms, but also recurrent hypoglycemia. The clinical phenotype varies from an exclusively neurological to a multi-organ manifestation. Methionine-restricted diet should be considered as a therapeutic option.9.
Nawal D. Alqarni Joanna Wysocka Nader El-Bagoury Jacek Ryl Mohammed A. Amin Rabah Boukherroub 《RSC advances》2018,8(34):19289
The electrochemical and corrosion (uniform and localized) behavior of a binary Ni52Ti48 shape memory alloy (SMA) and two ternary Ni52Ti48−xCox (x = 1.5 and 4.0 wt%) SMAs were studied. Measurements were conducted in 0.9% NaCl solution at 37 °C employing various electrochemical methods. These include: linear polarization resistance (LPR), linear sweep voltammetry (LSV), chronoamperometry and dynamic electrochemical impedance spectroscopy (DEIS). Such measurements were complemented with scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) analysis. Results revealed that the addition of alloyed Co to NiTi significantly reduced the uniform corrosion rate of the studied SMA and greatly enhanced its pitting corrosion resistance. XPS measurements evidenced high stability of the passive layer and limited adsorption of chloride ions. Additionally, it was found that the passive layer remained primarily composed of titanium oxides. Microstructure changes accompanying the addition of Co were also used to account for its role in improving the corrosion resistance of these materials.The electrochemical and corrosion (uniform and localized) behavior of a binary Ni52Ti48 shape memory alloy (SMA) and two ternary Ni52Ti48−xCox (x = 1.5 and 4.0 wt%) SMAs were studied. 相似文献
10.
Alsayed Salma N. Alharbi Asia G. Alhejaili Asrar S. Aljukhlub Reham J. Al-Amoudi Danih H. Ashankyty Asma I. Alzahrani Mansour A. Zughaibi Torki A. Alharbi Omar A. Kheyami Ali M. Helmi Nawal M. Tobaiqy Mansour A. Hershan Almonther A. Watson David G. Al-Asmari Ahmed I. 《Forensic Toxicology》2022,40(1):19-48
Forensic Toxicology - This review presents the current methods used for determining ethyl glucuronide (EtG) and ethyl sulfate (EtS) concentrations in postmortem specimens, including sample... 相似文献