全文获取类型
收费全文 | 2566篇 |
免费 | 143篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 115篇 |
妇产科学 | 183篇 |
基础医学 | 229篇 |
口腔科学 | 20篇 |
临床医学 | 249篇 |
内科学 | 487篇 |
皮肤病学 | 10篇 |
神经病学 | 248篇 |
特种医学 | 192篇 |
外科学 | 364篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 95篇 |
眼科学 | 25篇 |
药学 | 236篇 |
中国医学 | 4篇 |
肿瘤学 | 240篇 |
出版年
2023年 | 14篇 |
2022年 | 17篇 |
2021年 | 36篇 |
2020年 | 20篇 |
2019年 | 31篇 |
2018年 | 40篇 |
2017年 | 32篇 |
2016年 | 30篇 |
2015年 | 38篇 |
2014年 | 51篇 |
2013年 | 80篇 |
2012年 | 105篇 |
2011年 | 102篇 |
2010年 | 65篇 |
2009年 | 79篇 |
2008年 | 92篇 |
2007年 | 104篇 |
2006年 | 107篇 |
2005年 | 141篇 |
2004年 | 105篇 |
2003年 | 86篇 |
2002年 | 82篇 |
2001年 | 75篇 |
2000年 | 57篇 |
1999年 | 88篇 |
1998年 | 65篇 |
1997年 | 83篇 |
1996年 | 58篇 |
1995年 | 54篇 |
1994年 | 56篇 |
1993年 | 43篇 |
1992年 | 54篇 |
1991年 | 64篇 |
1990年 | 52篇 |
1989年 | 59篇 |
1988年 | 59篇 |
1987年 | 47篇 |
1986年 | 40篇 |
1985年 | 51篇 |
1984年 | 32篇 |
1983年 | 26篇 |
1982年 | 25篇 |
1981年 | 17篇 |
1980年 | 16篇 |
1979年 | 19篇 |
1978年 | 18篇 |
1977年 | 16篇 |
1975年 | 11篇 |
1974年 | 13篇 |
1973年 | 10篇 |
排序方式: 共有2720条查询结果,搜索用时 93 毫秒
1.
Sarah A. Taylor Jacqueline Benedetti David Schuller Stephen P. Richman Goronwy O. Broun Alexander Hantel 《Investigational new drugs》1993,11(2-3):227-229
Summary Twenty-two patients with recurrent or metastatic squamous cell carcinoma of the head and neck were treated with piroxantrone 150 mg/m2 intravenously every 21 days. There were no objective responses. The 95% upper confidence bound for response is 15%. Primary toxicity was hematologic. 相似文献
2.
M Strolin Benedetti E Pianezzola D Fraier M G Castelli P Dostert 《Xenobiotica; the fate of foreign compounds in biological systems》1991,21(4):473-480
1. The (13S)-dihydro derivative of idarubicin, (13S)-idarubicinol, is the major urinary metabolite of idarubicin in humans. Idarubicinol epimers were quantified by h.p.l.c. in urine from rats, mice, rabbits, dogs and man after i.v. administration of idarubicin, and in man after oral dosing. The (13R)- and (13S)-epimers of idarubicinol were determined in rat bile. 2. After i.v. injection of idarubicin. (13R)-idarubicinol was not detectable in mice and rabbit urine and no more than 0.5% of the dose was present in the urine of other species. In man, the proportion of (13R)-idarubicinol in total idarubicinol was similar after i.v. (4.1%) and oral (3.8-5.0%) administration of idarubicin; the same applies to rat bile and urine. 3. Reduction of idarubicin in vivo is dependent upon ketone reductases, and proceeds more stereoselectively than that of most ketones giving rise to the (13S)-epimer almost exclusively. The high stereospecificity in idarubicin reduction might result from chiral induction due to the presence of asymmetric centres near to the carbonyl group in idarubicin. 相似文献
3.
Intracranial circulation: pulse-sequence considerations in three- dimensional (volume) MR angiography 总被引:2,自引:0,他引:2
The technique and feasibility of magnetic resonance (MR) angiography of intracranial vessels were studied in 35 healthy volunteers. Variations in image orientation, repetition time (TR), and flip angle were evaluated to determine their effects on flow-related enhancement. Gradient modifications--including echo time (TE), motion compensation, bandwidth, and field of view--were also studied in an effort to reduce motion-induced phase shifts. Results indicated that a FISP (fast imaging with steady precession) sequence with a TR of 50 msec, TE of 15 msec, velocity compensation in the read and section-select directions, acceleration compensation in the read direction, anisotropic volume, and a 1.25-mm partition thickness produced three-dimensional angiographic MR images that were accurate and reproducible in the depiction of the major intracranial vessels. Difficulties with field of view, persistent signal void secondary to higher-order motion, and spatial resolution remain major problems requiring additional study. 相似文献
4.
Paediatric dacryocystorhinostomy 总被引:1,自引:0,他引:1
KN Hakin FRCS FRCOphth TJ Sullivan FRACO FRACS A Sharma FCOphth † RAN Welham FRCS FCOphth † 《Clinical & experimental ophthalmology》1994,22(4):231-235
Of 258 cases of dacryocystorhinostomy performed on children in the period September 1981 to September 1991, 130 were for simple, unresolved congenital nasolacrimal duct obstruction. Other indications for surgery included punctal agenesis, lacrimal fistula, post-traumatic and post-inflammatory canalicular obstruction. Of 177 children without canalicular pathology, 171 (96%) were relieved of symptoms with one operation, without canalicular intubation. Of 81 cases with canalicular disease, 55 of 70 (79%) who underwent DCR plus canalicular intubation, and 10 of 11 who underwent DCR plus Lester-Jones tube, were substantially improved with one operation. No child required peroperative or postoperative blood transfusion. Dacryocystorhinostomy in childhood, in experienced surgical hands, is a safe procedure, achieving relief of symptoms in most cases, particularly in the absence of canalicular disease. 相似文献
5.
Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth 总被引:1,自引:0,他引:1
G Scambia F O Ranelletti P Benedetti Panici G Bonanno R De Vincenzo M Piantelli S Mancuso 《Anti-cancer drugs》1990,1(1):45-48
It has been demonstrated that the flavonoid quercetin (3,3',4',5-7-pentahydroxyflavone) (Q) inhibits the growth of several cancer cell lines and that the antiproliferative activity of this substance is mediated by a so-called type II estrogen binding site (type II EBS). We investigated the effects of quercetin and cisplatin (CDDP) alone and in combination on the proliferation of the ovarian cancer cell line OVCA 433. Both drugs exhibited a dose-related growth inhibition in a range of concentrations between 0.01 and 2.5 microM and 0.01 and 2.5 micrograms/ml for Q and CDDP respectively. The combination of the two drugs resulted in a synergistic antiproliferative activity. Two other flavonoids tested, i.e., rutin (3-rhamnosylglucoside of quercetin) and hesperidin [7-b rutinoside of hesperetin (3'-5-3-hydroxy-4-methoxyflavone)] were ineffective both alone and in combination with CDDP. Since both rutin and hesperidin do not bind to type II EBS it can be hypothesized that Q synergizes with CDDP by acting through an interaction with these binding sites. 相似文献
6.
7.
8.
Factors influencing women to undergo screening mammography 总被引:2,自引:0,他引:2
9.
10.
D. M. F. Edwards C. Pellizzoni H. P. Breuel A. Berardi M. G. Castelli E. Frigerio I. Poggesi M. Rocchetti A. Dubini M. Strolin Benedetti 《Biopharmaceutics & drug disposition》1995,16(6):443-460
The pharmacokinetics of reboxetine, a new antidepressant agent, were found to be close to linear in a crossover study comparing administration of single 2, 3, 4 and 5 mg capsule doses in 15 healthy male volunteers, and in the same study the capsules were bioequivalent to the proposed therapeutic tablet formulation (4mg). Kinetic analysis was based on HPLC assay of reboxetine in plasma and urine collected up to 72 h after each administration. Plasma levels indicated a rapid absorption (tmax?2h) and an elimination half-life of about 13 h. Clearance and volume of distribution were modest (ratios to bioavailability: CL/F?29 mL min?1; Vz/F?32L); urinary excretion was ~9% of dose, corresponding to a renal clearance of only 3 mL min?1 (a value consistent with the rate of glomerular filtration of unbound drug). In vitro, binding to plasma proteins, estimated from radioactivity levels following dialysis of 14C-labelled reboxetine, appeared to be dominated by α1-acid glycoprotein without marked saturation up to plasma concentrations of over 500 ng mL?1 (2.8–3.1% unbound with human plasma from three additional volunteers; 1.8–2.0% for 2gL?1 orosomucoid α1-acid glycoprotein, and 46.4–47.4% for 40 gL?1 albumin), whilst the mean Cmax in the current study was much lower (164 ng mL?1 after a 5 mg dose). 相似文献