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排序方式: 共有1385条查询结果,搜索用时 15 毫秒
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2.
Masafumi Kataoka Kaori Shigemitsu Shunsuke Tanabe Toshinori Ohara Takaomi Takahata Soichiro Nose 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(7):365-368
A 67-year-old man was admitted to our hospital due to esophageal cancer. Cancer existed at the lower esophagus and subtotal esophagectomy and lymphadenectomy was performed. The postoperative course was uneventful. Pathological findings revealed moderately differentiated squamous cell carcinoma that metastasized to the abdominal lymph nodes which include the paraaortic lymph nodes. He complained of anorexia three months after the operation and was found to have multiple liver and mediastinal lymph node metastases. He was admitted for chemotherapy. Before starting chemotherapy, he suddenly died without any sign of hemorrhage or respiratory disorder. Autopsy showed metastatic lesions to the heart and mediastinal lymph nodes, liver, thoracic vertebrae, kidney, adrenal gland and heart. Metastatic nodules in the heart were on the ventricular septum where the conducting system exists. No direct invasion from the pericardium was observed. Blockade of the conducting system of the heart was considered to have caused the severe arrhythmia and sudden cardiac arrest. 相似文献
3.
Shoji Matsushima Yuko Sakai Yoshiki Hira Masamichi Kato Tsukasa Shigemitsu Yoichi Shiga 《Journal of pineal research》1993,14(3):145-150
Abstract: Light microscopic observations on the superficial pineal gland of Wistar-King rats were made to examine whether or not pineal volume and pinealocyte size, expressed as nuclear density, at daytime or nighttime are affected by long-term exposure to 50 Hz rotating magnetic field (MF) at 5.0 μT. Determinations of pineal volume and pinealocyte size were repeated twice (April and October) during the year. Size of pinealocytes in MF-exposed and sham-exposed rats exhibited, in addition to the difference between peripheral and central regions, regional differences in a proximodistal direction; pinealocytes in the distal and middle-peripheral regions were usually larger than those in the proximal and middle-central regions at daytime or nighttime. In October, distal and proximal pinealocytes showed significant day-night changes in size in sham-exposed rats, but not in MF-exposed animals. The situations in the two groups were almost reversed in April. Significant day-night differences were scarcely found in pinealocyte size in the middle region in the two groups. Throughout the study, pineal volume and pinealocyte size in each region were generally the same between MF-exposed and sham-exposed rats at daytime or nighttime. The results suggest that pinealocytes in the distal and proximal regions, but not those in the middle region, are affected by MF-exposure; day-night differences in sizes of distal and proximal pinealocytes appear in April and disappear in October under the influence of MF. MF may exert an effect on mechanisms controlling day-night rhythms of pinealocyte size in the rat. 相似文献
4.
Shinichiro Maeshima Jun Tanemura Aiko Osawa Miho Kawarada Eri Sekiguchi Toru Itakura 《Brain and nerve》2006,58(3):207-211
To investigate the usefulness of the frontal assessment battery (FAB) as a brief assessment for diagnosis in patients with dementia, we examined cognitive function using the FAB, Mini-mental state examination (MMSE), Kana-hiroi test, and Raven's colored progressive matrices (RCPM). Subjects were 82 senile patients having amnesia as a complaint including 28 Alzheimer's disease (AD), 14 frontotemporal dementia (FTD), 17 vascular dementia (VD), 13 mild cognitive impairment (MCI), and 10 healthy persons. We discussed the difference of scores in different types of dementia. In the FAB, the scores of healthy persons and MCI were much higher compared with the scores of all types of dementia. There were high correlation between FAB and MMSE, Kana-hiroi test, and RCPM. Although some subjects showed normal score in MMSE and/or RCPM, they showed low score in FAB. Based on this, FAB is efficient for the differential diagnosis of dementia as brief screening tool. 相似文献
5.
Whether or not compromised host defense prior to surgical treatment is related to development of infection with methicillin-resistant staphylococcus aureus (MRSA) following major surgery was examined. Of 22 patients undergoing esophagectomy for cancer between 1989 and 1990, 5 were free from MRSA colonization and infection (group I) while 8 had MRSA colonization without infection (group II) and 9 had MRSA infection (group III). Levels of neutrophil cytocidal functions, complements, immunoglobulins and cell-mediated immunity were not significantly different among these three groups. The mean of anti pneumococcal polysaccharide (PPS)-IgG was significantly lower in group III than in group I (p < 0.05) and tended to be lower than in group II (P = 0.08). All infected patients showed a titer < 600 EU while all but one non-infected patient did so > 600 EU. Serum IgG2 levels positively correlated with anti-PSS IgG levels. Thus, we concluded that a preoperative evaluation of antibody response against polysaccharides and serum IgG2 levels can serve to predict development of MRSA-related infection following esophageal surgery. 相似文献
6.
Morito Nakayama MD Naoyuki Kataoka MD Yutaka Usui MD Naohiko Inase MD Shigemitsu Takayama MD Hirotaro Miura MD 《The Journal of emergency medicine》1992,10(6):729-734
When nasotracheal intubation with a fiberoptic bronchoscope is performed, the tube may be blocked in the nasal cavity or larynx, resulting in several complications including epistaxis and hoarseness. We review the causes and complications of tube blockage and discuss optimal techniques for minimizing it. 相似文献
7.
Keiichi Ueda Shigemitsu Nakagawa Ken-ichi Kawahara Tomozo Fujita 《Medical molecular morphology》1993,26(3-4):191-194
Extirpated specimens of a squamous cell carcinoma from a human thigh were transplanted to the subcutaneous tissue of nude mice. Fourteen days later, the transplanted tumor masses were, again, extirpated from the nude mice. The transplanted chimera of the squamous cell carcinoma as seen with the electron microscope resembled the tumor cells before transplantation. It is concluded that ultrastructural investigation of transplanted chimera from squamous cell carcinoma cases may be useful for examining the site of action and clinical effects of anticancer drugs on this kind of tumor. 相似文献
8.
Claudio Oliveira Fausto Foresti Marcos Guilherme Rigolino Yara Aiko Tabata 《Chromosome research》1995,3(3):182-190
The surface-spreading synaptonemal complex (SC) technique was employed to analyze spermatocytes and oocytes of rainbow trout in order to visualize the process of autosome and sex chromosome synapsis in this species. The structure of lateral elements (LEs) of the SC and the chromosome synapsis process at the stages of leptotene, zygotene and pachytene are described. Comparative analysis of SCs of spermatocytes and oocytes showed a difference in the synaptic process, i.e. in spermatocytes all LEs were synapsed before the appearance of centromeric regions in the biarmed elements, while in the oocytes some fully synapsed LEs, including the centromeric region of the biarmed elements, were found together with fully or partially unsynapsed LEs. In males the sex chromosome synapsis starts only after all autosomes have synapsed. Irregular synapses involving three or four LEs were found in 3.4% of the cells analyzed in mid or late zygotene. Multivalents were found in males and females. Some aspects of initial meiotic development and their implications in rainbow trout cytogenetics, genetics and evolution are discussed. 相似文献
9.
Shigemitsu Iwai MD Kei Torikai MD Chris M. Coppin MD Yoshiki Sawa MD 《Journal of artificial organs》2007,10(1):29-35
Currently used bioprosthetic valves have several limitations such as calcification and functional deterioration, and revitalization
through cellular ingrowth is impossible. To overcome these obstacles, we have developed a minimally immunogenic tissue-engineered
valve that consists of an unfixed, decellularized porcine valve scaffold capable of being spontaneously revitalized in vivo
after implantation. Porcine aortic root tissue was decellularized using detergents such as sodium lauryl sulfate and Triton
X-100. The porcine valve was treated very gently and plenty of time was allowed for constituents to diffuse in and out of
the matrix. In a preliminary study, a piece of decellularized porcine valve tissue was implanted into the rat subdermal space
for 14 and 60 days and the structural integrity and calcification were evaluated. As an in vivo valve replacement model, the
decellularized porcine valve was implanted in the pulmonary valve position in dogs and functional and histological evaluation
was performed after 1, 2, and 6 months. Histological examination showed that the newly developed detergent treatment effectively
removed cellular debris from the porcine aortic tissue. Decellularized porcine valve tissue implanted subdermally in rats
showed minimal inflammatory cell infiltration and calcification. In the valve replacement model, spontaneous reendothelialization
and repopulation of the medial cells were observed within 2 months, and good valve function without regurgitation was observed
by echocardiography up to 6 months. The minimally immunogenic decellularized porcine valve proved effective in mitigating
postimplant calcification and provided a suitable matrix for revitalizing prostheses through in situ recellularization, cellular
ingrowth, and tissue remodeling. 相似文献