Hawkeye SPECT仪融合图像用于脑脊液鼻漏诊断和定位

Objective The purpose of this study was to evaluate the clinical value of the 99Tcm-DTPA cerebrospinal fluid (CSF) Hawkeye SPECT fusion imaging for diagnosing and localizing CSF rhinorrhea (CSFR). Methods Thirty-three patients with suspected CSFR were included in this study. All cases un-derwent planar and SPECT and CT imaging at 120 and 180 min, respectively, after 99Tcm-DTPA injection via lumbar puncture before surgery treatment. The location and path of CSF leakage were diagnosed on pla-nar and SPECT fusion imaging. SAS 6.12 software was used to analyze both sets of imaging data, and the χ2 test was used to compare the results from planar imaging with those of SPECT fusion imaging. Results In 33 patients with CSFR, 31 abnormally concentrated radionuclide activity and location of leakage were foun-ded on SPECT fusion imaging, whereas 30 of such abnormalities were detected by planar imaging. All CSFR cases were confirmed by surgery afterwards. The sensitivity and accuracy for diagnosing and localizing CSFR were 93.9% (31/33), 90.9% (30/33) in SPECT fusion imaging and 93.5% (29/31), 78.3% (18/23) in planar imaging. Conclusion 99Tcm-DTPA CSF Hawkeye SPECT fusion imaging is an efficient, simple and accurate method for diagnosing and localizing CSF leakage.     

~(18)F-FDG-PET/CT显像在胰腺炎和胰腺癌鉴别诊断中的应用

目的探讨~(18)F-FDG-PET/CT显像在鉴别诊断胰腺癌良恶性病变中的价值。方法选取我院2014年1月～2017年1月确诊的胰腺癌患者53例(恶性组)、慢性胰腺炎患者22(良性组),两组患者均接受了~(18)F-FDG-PET/CT显像检测,对比两组患者病灶早期、延迟期的最大标准摄取值(SUV),滞留指数(RI),并绘制受试者工作曲线(ROC)求取早期SUV、RI鉴别诊断胰腺癌的最佳临界值及对应的诊断学指标。结果恶性组的~(18)F-FDG-PET/CT显像早期SUV测定值、延迟期SUV测定值、RI值均显著的高于良性组患者,差异具有统计学意义(P 0. 05);当选取早期SUV的临界值为3. 07时,~(18)F-FDG-PET/CT显像诊断灵敏度为78. 82%、特异度为86. 14%、漏诊率为21. 18%、误诊率为13. 86%、AUC值为0. 846;当选取RI的临界值为14. 46时,~(18)F-FDG-PET/CT显像诊断灵敏度为87. 64%、特异度为95. 20%、漏诊率为12. 36%、误诊率为4. 80%、AUC值为0. 911。结论~(18)F-FDG-PET/CT显像在鉴别诊断胰腺癌良恶性病变中具有较高的临床实用价值。     

麝香保心pH依赖型梯度释药微丸和麝香保心丸的药效动力学

目的 探讨麝香保心pH依赖型梯度释药微丸和麝香保心丸的药效动力学参数。方法 以大鼠心肌营养性血流量为效应指标进行测定。结果 麝香保心丸在大鼠体内呈一室模型特征，其最低起效剂量为0.54mg/kg，效应呈现半衰期为0.53h，效应消除半衰期为1.21h，药效作用期为3.48h，效应达峰时间为1.13h，效量吸收半衰期为0.23h，消除半衰期为1.47h,达峰时间为0.88h,统计矩结果表明麝香保心pH依赖型梯度释药微丸和麝香保心丸的平均效应维持时间分别为5.05h和2.33h,效量平均滞留时间分别为7.70h和3.21h,麝香保心pH依赖型梯度释药微丸的效量相对生物利用度为104.03%.结论 麝香保心丸在体内具有吸收快,消除快和作用维持时间较短的特点,耐麝香保心pH依赖型梯度释药微丸在体内具有起效迅速,药效持久,缓和的特征.     

肝硬变扫描图形态学分型探讨——附50例肝扫描图资料分折

自1954年Stirret首创肝扫描以来,目前已成为肝癌诊断的重要方法。但核素扫描对肝硬变的诊断价值至今尚有争论,尤其对本病的扫描图形态与分型的看法也颇不一致。本文总结五十例经病理、手术探查和临床确诊为肝硬变的扫描图资料,就其形态与分型分析如下。     

Hawkeye SPECT仪融合图像用于脑脊液鼻漏诊断和定位

Objective The purpose of this study was to evaluate the clinical value of the 99Tcm-DTPA cerebrospinal fluid (CSF) Hawkeye SPECT fusion imaging for diagnosing and localizing CSF rhinorrhea (CSFR). Methods Thirty-three patients with suspected CSFR were included in this study. All cases un-derwent planar and SPECT and CT imaging at 120 and 180 min, respectively, after 99Tcm-DTPA injection via lumbar puncture before surgery treatment. The location and path of CSF leakage were diagnosed on pla-nar and SPECT fusion imaging. SAS 6.12 software was used to analyze both sets of imaging data, and the χ2 test was used to compare the results from planar imaging with those of SPECT fusion imaging. Results In 33 patients with CSFR, 31 abnormally concentrated radionuclide activity and location of leakage were foun-ded on SPECT fusion imaging, whereas 30 of such abnormalities were detected by planar imaging. All CSFR cases were confirmed by surgery afterwards. The sensitivity and accuracy for diagnosing and localizing CSFR were 93.9% (31/33), 90.9% (30/33) in SPECT fusion imaging and 93.5% (29/31), 78.3% (18/23) in planar imaging. Conclusion 99Tcm-DTPA CSF Hawkeye SPECT fusion imaging is an efficient, simple and accurate method for diagnosing and localizing CSF leakage.     

麝香保心丸增加大鼠心肌血流灌注量的药效动力学

目的　探讨麝香保心丸的药效动力学参数。方法　以大鼠心肌血流灌注量为指标进行测定。结果　麝香保心丸在大鼠体内呈一室模型特征 ,其最低起效剂量为 0 .5 4mg·kg-1,效应呈现半衰期为 0 .5 3h ,效应消除半衰期为 1.2 1h ,药效作用期为 3.4 8h ,效应达峰时间为 1.13h ,体存生物相当药量的吸收半衰期为 0 .2 3h ,消除半衰期为 1.4 7h ,达峰时间为 0 .88h。结论　麝香保心丸在体内具有吸收快、消除快和作用维持时间较短的特点     

原发性肝癌~(99m)Tc—PMT阳性显像的诊断价值

~(99m)Tc-N-pyridoxyl-5-methyltryptophan(~(99m)Tc-PMT)是比较理想的肝胆道显像剂,其特点是静注后,除很快从肝胆系排泄外,可被原发性肝癌癌变细胞摄取,出现肝癌阳性显像。本文报道20例原发性肝癌中有14例,在癌病灶部位有浓集~(99m)Tc-PMT,阳性率为70%。14例阳性显像中11例(78.5%)于静注后2小时可见浓集,直径小于3cm者2例均未浓集,直径3～5.9cm 7例中6例(85.7%)可见农集,直径10cm以上者5例均可见浓集。浓集的形态可分为点状、片状和环状。     

^99mTc-MIBI双嘧达莫负荷显像评估心肌细胞损伤和再灌注后的可修复性

目的 研究犬陈旧性心肌梗死(陈旧心梗)损伤区心肌细胞损伤与修复的形态学变化与^99mTc—MIBI摄取量的关系。方法 选择犬12只，建立陈旧心梗模型，5个月后取心脏，通过透射电镜(TEM)观察^99mTc-MIBI硝酸甘油介入和双嘧达莫负荷心肌显像缺损区和可逆性缺损区内心肌细胞的超微结构。结果 硝酸甘油介入^99mTc—MIBI放射性分布缺损区无完整的心肌细胞；^99mTc-MIBI双嘧达莫负荷心肌显像可逆性缺损区，主要为低血流灌注的心肌细胞，心肌细胞部分线粒体肿胀、变形严重，基质密度下降、有灶状空化，线粒体空泡散在分布、少数连续分布，膜和嵴不完整；部分线粒体轻度变形，基质密度降低程度较轻，有点状空化，嵴排列不整齐或部分凋落。在近正常心肌一侧，多数心肌细胞的线粒体近似卵圆形，线粒体膜基本完整，基质密度轻度降低，嵴排列较整齐，偶见损伤较严重的线粒体。结论 ^99mTc-MIBI的心肌摄取量与细胞损伤的程度有关；在^99mTc-MIBI心肌显像可逆性缺损区，血流灌注改善后，大部分损伤的心肌细胞有修复的可能性。     

同位素~(32)P贴敷蝶腭神经节治疗神经血管性鼻炎

我科自1981年9月以来用同位素32P贴敷蝶腭神经节治疗神经血管性鼻炎,近期疗效较为满意,现总结分析如下。 材料与方法 将32p吸附在2×0.5cm大小的滤纸上,总剂量为3.7×107Bq(1mCi),外面用薄塑料膜密封。治疗前2％地卡因(加肾上腺素)鼻粘膜麻醉,再将32P敷贴片置于蝶腭神经节处。每次剂量为10Gy(1000r),3次为1个疗程。结果疗效判定标准:(1)显效:自觉症状基本消失或偶有小发作,鼻粘膜肿胀消退,(2)有效:自觉症状减轻,鼻粘膜肿胀减轻;(3)无效:自觉症状无变化或短期改善又复发。 本组47例中男32例、女15例,年龄21～54岁。随访3～12个月,共33例(70％)。显效14例,有效15例,无效4例,有效率88％。 讨 论 习惯上把凡有阵发性喷嚏,清水样鼻涕统称为过敏性鼻炎,现在把除花粉症以外者一律称为常年性鼻炎。包括常年性变态反应性鼻炎,嗜酸细胞增多性非变应鼻炎综合征及植物神经性常年性鼻炎3种。它们的临床表现类似,     

Hawkeye SPECT仪融合图像用于脑脊液鼻漏诊断和定位

Objective The purpose of this study was to evaluate the clinical value of the 99Tcm-DTPA cerebrospinal fluid (CSF) Hawkeye SPECT fusion imaging for diagnosing and localizing CSF rhinorrhea (CSFR). Methods Thirty-three patients with suspected CSFR were included in this study. All cases un-derwent planar and SPECT and CT imaging at 120 and 180 min, respectively, after 99Tcm-DTPA injection via lumbar puncture before surgery treatment. The location and path of CSF leakage were diagnosed on pla-nar and SPECT fusion imaging. SAS 6.12 software was used to analyze both sets of imaging data, and the χ2 test was used to compare the results from planar imaging with those of SPECT fusion imaging. Results In 33 patients with CSFR, 31 abnormally concentrated radionuclide activity and location of leakage were foun-ded on SPECT fusion imaging, whereas 30 of such abnormalities were detected by planar imaging. All CSFR cases were confirmed by surgery afterwards. The sensitivity and accuracy for diagnosing and localizing CSFR were 93.9% (31/33), 90.9% (30/33) in SPECT fusion imaging and 93.5% (29/31), 78.3% (18/23) in planar imaging. Conclusion 99Tcm-DTPA CSF Hawkeye SPECT fusion imaging is an efficient, simple and accurate method for diagnosing and localizing CSF leakage.