产前诊断X连锁脑积水综合征1例合并文献复习

<正>人类脑积水大约有40%被认为由基因突变引起^[1]。作为目前唯一明确的单基因所致的脑积水,X连锁脑积水综合征占先天性脑积水的5%～15%^[2]。其临床表现为：男性患儿(胎儿)、脑积水、胼胝体发育不良、精神发育迟滞、拇指内收、痉挛性截瘫等。目前尚无有效根治方法,对患儿家庭及社会造成严重负担。但作为其主要就诊原因的胎儿脑室扩张通常开始于妊娠20周后或孕晚期,也可能发生于产后甚至不发生^[3],其最具有特征性的体征拇指内收在胎儿期较难观察,     

复发性流产史孕妇早孕期超声筛查胎儿异常与染色体异常相关性

目的 探讨复发性流产史孕妇早孕期超声筛查胎儿结构异常及与染色体异常的相关性.方法 选取我院行产检的451例复发性流产史孕妇临床资料,均在孕11 ～13+6周前建档并规律行超声筛查,并行随访,超声检查有异常者均获取染色体检查结果.结果 早孕期、中晚期超声检出46例共82处结构异常,检出率10.20％ (46/451).染...     

Anti-viral effects of urosolic acid on guinea pig cytomegalovirus in vitro

This study examined the anti-viral effect of ursolic acid on guinea pig cytomegalovirus (GPCMV) and explored the steps of viral replication targeted by ursolic acid. Cytopathic effect assay and MTT method were employed to determine the 50% cellular cytotoxicity (CC50), 50% effective concentration (EC50) and therapeutic index (TI) with GPCMV. To investigate the specific anti-viral effect of ursolic acid at different temperatures and time points, two other medicines, ganciclovir and Jinyebaidu (JYBD), serving as controls, were studied for comparison. Our results showed that the CC50 of ganciclovir, JYBD and ursolic acid were 333.8, 3015.6, 86.7 μg/mL, respectively; EC50 of ganciclovir, JYBD and ursolic acid was 48.1, 325.5 and 6.8 μg/mL, respectively; TI of ganciclovir, JYBD and ursolic acid was 7, 9, 13, respectively. Similar with ganciclovir, ursolic acid could inhibit the viral synthesis, but did not affect the viral adsorption onto and penetration into cells. We are led to conclude that the anti-cytomegalovirus effect of ursolic acid is significantly stronger than ganciclovir or JYBD, and the cytotoxic effect of ursolic acid lies in its ability to inhibit viral synthesis.     

经阴道彩色多普勒超声检查在剖宫产切口瘢痕妊娠诊断中的应用价值

目的 探讨经阴道彩色多普勒超声检查在剖宫产切口瘢痕妊娠诊断中的临床应用价值.方法 回顾性分析本院术后确诊的41例瘢痕妊娠患者(观察组)及35例剖宫产术后正常妊娠患者(对照组)的临床资料及声像图特点.对比两组剖宫产切口处肌层厚度及妊娠囊下缘与宫颈内口的距离.结果 观察组与对照组平均肌层厚度分别为(2.47±0.92) mm、(4.50±1.19) mm,差异有统计学意义(P=0.000);观察组与对照组妊娠囊下缘与宫颈内口的距离分别为(6.09±1.45) mm、(16.3±3.93) mm,差异有统计学意义(P-0.000).结论 剖宫产切口处肌层厚度以及妊娠囊下缘与宫颈内口的距离是诊断剖宫产切口瘢痕妊娠的敏感指标.