全文获取类型
收费全文 | 780篇 |
免费 | 17篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 77篇 |
妇产科学 | 43篇 |
基础医学 | 42篇 |
口腔科学 | 67篇 |
临床医学 | 73篇 |
内科学 | 136篇 |
皮肤病学 | 5篇 |
神经病学 | 44篇 |
特种医学 | 22篇 |
外科学 | 180篇 |
综合类 | 32篇 |
预防医学 | 26篇 |
眼科学 | 9篇 |
药学 | 24篇 |
中国医学 | 19篇 |
肿瘤学 | 15篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 8篇 |
2021年 | 18篇 |
2020年 | 13篇 |
2019年 | 12篇 |
2018年 | 15篇 |
2017年 | 11篇 |
2016年 | 28篇 |
2015年 | 15篇 |
2014年 | 20篇 |
2013年 | 15篇 |
2012年 | 84篇 |
2011年 | 119篇 |
2010年 | 37篇 |
2009年 | 33篇 |
2008年 | 49篇 |
2007年 | 49篇 |
2006年 | 36篇 |
2005年 | 40篇 |
2004年 | 40篇 |
2003年 | 32篇 |
2002年 | 43篇 |
2001年 | 24篇 |
2000年 | 36篇 |
1999年 | 21篇 |
1998年 | 3篇 |
1996年 | 2篇 |
1989年 | 3篇 |
1967年 | 1篇 |
1949年 | 1篇 |
1941年 | 3篇 |
1939年 | 1篇 |
1936年 | 3篇 |
1935年 | 1篇 |
1931年 | 2篇 |
排序方式: 共有820条查询结果,搜索用时 15 毫秒
1.
目的通过对南阳地区≤5岁儿童社区获得性肺炎(CAP)患儿下呼吸道分泌物病原菌的检测,探讨近年儿童CAP病原菌构成和耐药谱的新特点。
方法选择2003 11—2005 12来自南阳地区各不同社区于南阳医专附院儿科就诊,符合肺炎诊断标准的儿童CAP住院患者1276例,用多平板不同条件对未抗菌治疗采得的标本进行接种培养,分离菌株采用Bio Merieux VITEK 2型全自动微生物仪进行菌种鉴定和药物敏感试验,结果采用WHONET5软件分析处理,得出儿童CAP病原菌种分布构成比及主要致病菌种对常用抗菌药物的耐药率。
结果检出病原菌以革兰阴性菌为主,占68.6%(297/433),其中前3位分别为大肠埃希菌、肺炎克雷伯菌及铜绿假单胞菌。6种主要革兰阴性菌对氨苄西林、复方磺胺、头孢唑啉显示高抗药性,而对美洛培南、亚安培南高度敏感,对阿米卡星、头孢吡肟较敏感。4种主要革兰阳性菌对万古霉素高度敏感,对利福平、氨苄西林/舒巴坦及左氧氟沙星较敏感。
结论儿童CAP病原菌构成在发生变迁,细菌的耐药性也在发生改变,且各地及不同时期存在差异,故应作好病原及药敏监测并改进检测方法,掌握本地区一定时期内儿童CAP的病原学情况。 相似文献
2.
目的 比较不同栓塞材料的门静脉栓塞术(PVE)与联合肝脏分隔和门静脉结扎的二步肝切除术(ALPPS)对剩余肝体积(FLR)增长速率的影响,比较各组FLR的增长速率,二期手术切除率、术中数据和术后并发症。方法 采用单中心、前瞻性、非随机对照的对比研究。2014年11月至2019年12月,海军军医大学第三附属医院共126例因FLR不足导致无法切除的肝细胞癌(HCC)或肝内胆管癌(ICC)病人,将其分为4组:ALPPS组及分别采用氰基丙烯酸正丁酯(NBCA)、微球、明胶海绵作为栓塞材料的PVE组。主要终点为FLR增长速率和二期手术切除率。结果 各组的手术切除例数及二期手术切除率分别为:ALPPS组38例(99.4%),NBCA组32例(76.2%),明胶海绵组20例(60.6%),微球组10例(83.3%)。ALPPS组、NBCA组、微球组的FLR增长速率分别为15.1 mL/d,10.0 mL/d和 8.5 mL/d,均高于明胶海绵组(3.7 mL/d)。结论 采用NBCA及微球作为栓塞材料的PVE导致FLR增长速率低于ALPPS,两种栓塞材料的PVE二期手术切除率相当。使用NBCA作为栓塞材料的PVE其FLR增长速率高于微球,且这两种栓塞材料的栓塞效果均优于明胶海绵。 相似文献
3.
4.
Psotová J Chlopcíková S Miketová P Hrbác J Simánek V 《Phytotherapy research : PTR》2004,18(7):516-521
Flavonoids are found universally in plants and act as free radical scavenging and chelating agents with antiinflammatory, antiischemic, vasodilating and chemoprotective properties. In this study, the antilipoperoxidative and cytoprotective effects of apigenin, baicalein, kaempferol, luteolin and quercetin against doxorubicin-induced oxidative stress were investigated in isolated rat heart cardiac myocytes, mitochondria and microsomes. After preincubation of cardiomyocytes with the test compounds for 1 h the cardiomyocytes were treated with the toxic agent, doxorubicin (100 micro M for 8 h). Cardiomyocyte protection was assessed by extracellular LDH and cellular ADP and ATP production. Cytoprotection was concentration dependent for baicalein > luteolin congruent with apigenin > quercetin > kaempferol. All test compounds had signi fi cantly better protective effects than dexrazoxan, an agent currently used for adjuvant therapy during anthracycline antibiotic therapy. In microsomes/mitochondria the IC(50) values of lipid peroxidation inhibition for quercetin, baicalein, kaempferol, luteolin, and apigenin were 3.1 +/- 0.2/8.2 +/- 0.6, 3.3 +/- 0.3/9.6 +/- 0.5, 3.9 +/- 0.3/10.1 +/- 0.8, 22.9 +/- 1.7/18.2 +/- 0.7, and 338.8 +/- 23.1/73.1 +/- 6.4 mM, respectively. The antilipoperoxidative activity of apigenin differed from its cytoprotective effects, but correlated with the free radical scavenging of 2,2-diphenyl-1-picrylhydrazyl radical and half peak oxidation potential (E(p/2)). Apigenin was the least effective of the flavonoids studied in all models except the cardiomyocyte model where its cardiomyocyte cytoprotective effect was comparable to other compounds. 相似文献
5.
目的:观察胃广平颗粒治疗脾虚气滞型功能性消化不良的临床疗效。方法:将120例脾虚气滞型功能性消化不良患者随机分为治疗组和对照组各60例,对照组予促胃肠动力常规治疗,治疗组予胃广平颗粒治疗。两组均以4周为1个疗程。观察两组临床疗效及6项主要症状积分情况。结果:总有效率治疗组为96.6%,对照组为83.3%,组间比较,差异有统计学意义(P0.05);6项症状积分两组治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P0.05)。结论:胃广平颗粒治疗脾虚气滞型功能性消化不良疗效肯定,值得临床推广应用。 相似文献
6.
7.
Basgul A Güdücü N Kavak ZN Gökaslan H Uyar E 《Clinical and experimental obstetrics & gynecology》2007,34(3):182-184
INTRODUCTION: We present three cases of fetuses diagnosed as Turner syndrome with cystic hygroma (CH) developing hydrops to discuss the prenatal diagnostic and prognostic criteria of CH in ultrasound and outcome of the fetuses. CASES: The first case was 30-year-old pregnant woman with a nuchal translucency measurement of 8 mm at 12 weeks' gestation. Serial ultrasound examinations revealed non-septated cystic hygroma and hydrops. The pregnancy was terminated at the 18th week of gestation. Diagnosis of CH was made at 14 and 15 weeks of gestation in case 2 and case 3, respectively. Ultrasound revealed large cystic septated sacs in the nuchal area combined with serosal fluid collection and cutaneous edema. Spontaneous fetal demise occured at 21 and 16 weeks of gestation in cases 2 and 3, respectively. All fetuses were diagnosed as Turner syndrome. 相似文献
8.
Salihoğlu Y Keskin N Topuz S Küçücük S Iyibozkurt C 《European journal of gynaecological oncology》2007,28(4):313-315
OBJECTIVE: To determine the risk of vaginal recurrence in Stage 1 endometrial cancer and treatment morbidity associated with different therapeutic approaches MATERIAL AND METHODS: Between 1995 and 2005, 341 patients with clinical Stage I endometrial cancer were treated at Istanbul Medical Faculty. One hundred and forty-four women were included in this study as the follow-ups and records were complete. The patients with no myometrial invasion received no further therapy following hysterectomy. When there was superficial myometrial invasion postoperative vaginal vault radiation was used, and if deep myometrial invasion was present, external pelvic radiation was given. RESULTS: Overall 5-year survival rate for all patients with Stage I disease was 80%. Nine patients (6.25%) developed recurrent disease, three of whom had vaginal recurrences. All three vaginal recurrences were small and diagnosed at routine follow-up exam within 51 months of primary therapy. CONCLUSION: This selective treatment protocol for patients with Stage I endometrial cancer avoided radiation entirely in 38% of the patients while achieving a very low rate of vaginal recurrence and good overall survival. 相似文献
9.
辛世杰a 张珈玮a 张健a 付凌雨b 杨昱a 马文峰a 宋清斌a 罗英伟a 王传疆a 胡新华a 张赞松a 杨栋a 周宝森c 胡海地a 史潇兮a 程帅a 刘远霖a 段志泉a 《中国实用外科杂志》2021,41(12):1384-1393
目的 回顾性分析近10年中国医科大学附属第一医院收治的腹主动脉瘤(AAA)病人的流行病学特点,为研究近10年AAA流行病学变化趋势,以及为AAA的进一步预防和诊治提供依据。方法 纳入自2011年1月至2020年12月中国医科大学附属第一医院诊治的1246例AAA病人的病案资料,回顾性分析包括病人年龄、性别、就诊时间、就诊科室、首发症状、住院时间、住院费用、术式选择等信息,分析近10年AAA流行病学变化特点。结果 入院病人平均年龄为(66.9±10.5)岁,男女占比约为4∶1。男性AAA病人以同型半胱氨酸升高为主,女性以血脂升高为主。AAA病人的主要合并症为3级高血压(41.9%)、冠心病(31.1%)和合并髂动脉瘤(25.8%)。男性AAA合并髂动脉瘤比率明显高于女性(27.8% vs.17.8%,P<0.01)。72.7%的AAA病人首诊原因为体检发现,其次是AAA破裂(18.7%)。AAA病人急诊与门诊就诊例数呈逐年升高态势,急诊与门诊就诊占比约为2∶3。65~69岁为现阶段住院病人主要年龄段。各年份男性占比约为80%,年龄段65~69岁为男性占比可达近90%。各年份腔内修复术(EVAR)是AAA的主要治疗方式,行EVAR治疗病人的例数和比例总体趋势逐年增加,行EVAR治疗的占比随病人年龄增加而逐渐增大。近10年AAA病人的病死率呈降低趋势,2015年后病死率总体维持在2%~3%,以男性为主,年龄段70~74岁的病死率最高为5.8%。AAA病人平均住院(17.0±16.4)d,平均住院费用为(11.3±10.7)万元。结论 近10年AAA住院病人有逐年增高趋势,主要患病人群为年龄>60岁男性,男女临床特点有较大差异。采用EVAR治疗的占比逐年增加。对于老年AAA人群,尤其是年龄段65~69岁男性AAA病人,在AAA的防治过程中应给予更多关注。 相似文献
10.
Τ ��a��Ҷ�ຣb����һ�tc�����ľ�a���� ��d���� ��a��������c���� ��e���� 《中国实用外科杂志》2014,34(9):862-865
??Multi-disciplinary team and conversion therapy for colorectal cancer with unresectable liver metastases??A report of 86 patients WEI-Ye*??YE Qing-hai??YU Yi-yi??et al. *Department of General Surgery, Zhongshan Hospital??Fudan University??Shanghai200032??China
Corresponding author??QIN Xin-yu??E-mail??qin.xinyu@zs-hospital.sh.cn
Abstract Objective To analyze safety and effect of the conversion therapy for initially unresectable colorectal liver metastases (CLMs) under the guidance of multi-disciplinary team (MDT). Methods The retrospective analysis was conducted for 86 patients with unresectable CLMs received MDT management and arrived conversion therapy successfully from January 2008 to December 2011 in Zhongshan Hospital of Fudan University. The perioperative and survival outcomes??prognostic factors were evaluated. Results During the mean follow-up of 41 months (24-68 months), according to the finding time of liver metastases of 86 patients??recurrence events were 73 patients??and 39 patients died. The 1 year??2 year and 3 year overall survival rate (OS) was 90.6%??75.6% and 65.1% respectively. The median OS time was ??47.5±3.1?? months. The 1 year??2 year and 3 year disease free survival rate (DFS) was 72.1%??48.8% and 31.4% respectively. The median DFS time was ??22.0±2.9?? months. The OS and DFS were no significant difference when compared 86 patients with initially unresectable CLMs successfully arrived conversion therapy with 99 patients with initial resectable CLMs??P >0.05??. The perioperative mortality rate was 1.5%??and operative complication rate was 24.4%. Tumor regression grade and early tumor shrink could predict the prognosis of CLM patients received conversion therapy. Conclusion The conversion therapy under the guidance of MDT mode is safe and effective for unresectable CLMs. The mid-term survival rate is similar with initially resectable CLMs??and long-term survival is expected. 相似文献