坐骨棘筋膜固定术的临床解剖学研究

Objective The study was to explore the safety, firmness and convenience of the fascia around the ischial spine as a new fixation site for the vaginal fornix. Methods Between June 2007 and January 2008, detailed dissections and related measurements of the regions around the ischial spine were performed on 10 Chinese female cadavers (3 unembalmed and 7 embalmed cadavers). At the same time, the sacrospinous ligament,the fascia on the ischial spine, the iliococcygeus fascia as well as the vaginal fornix were exposed and the pull-out strength sequentially tested using a digital push-pull force gauge. Results The fascia on the ischial spine was firm and strong, with a thickness of 3 about mm. No major vessels or nerves were observed on the ischial spine. The greatest pullout strengths of the sacrospinous ligament,the fascia on the ischial spine, the iliococcygeus fascia as well as the vaginal fornix were (102±26),(64±15),(33±8)and(32±6)N, respectively. Conclusion The fascia at 1 cm from anterior lateral ischial spine, free of major vessels and nerves, is safe and strong and could be used as a new site for suspension in vaginal prolapse.     

新生儿盲肠的解剖学观测

为积累新生儿体调资料,对100例新生儿盲肠的位置、形态与腹膜的关系、回盲口的位置和形态、各经线等进行了解剖观测。     

一起亚硝酸盐食物中毒引发的损害赔偿案

20 0 2年9月18日,辽宁省鞍山市发生了一起亚硝酸盐食物中毒案,由于当地卫生监督部门采取措施得力,中毒原因判断迅速、准确,该事件的发生范围控制到了最小程度,所有中毒患者均经抢救后脱险。该起食物中毒案经卫生监督部门定性并对肇事者给予行政处罚后,引发了一起较大数额的民事赔偿案,现将该案件分析如下。1　事情简介1 1　事件的发生　2 0 0 2年9月18日中午,赵某在鞍山市某大型食品商场购得豆制品回到家中共同食用。0 5h后,二人出现头晕、恶心、呕吐、四肢发冷、口唇青紫、呼吸困难等症状。另有孙某在该食品商场购得此豆制品中午与丈夫共…     

尿液潜血两种检验方法的比较

目的对尿液分析仪检测尿潜血反应和镜检红细胞（RBC）的结果进行分析比较。方法对400份门诊患者留取的随机尿液立即按照仪器操作说明进行尿液分析仪检验和尿沉渣显微镜检查。结果尿液分析仪潜血反应阳性，镜检有红细胞的有166例，镜检无红细胞的有24例。尿液分析仪潜血反应阴性镜检有红细胞的有12例，镜检无红细胞的有198例。两种方法结果出现差异。结论临床工作中尿液分析仪潜血反应与显微镜检查红细胞应联合进行，尤其是显微镜检查至关重要，不可忽视。     

坐骨棘筋膜固定术的临床解剖学研究

Objective The study was to explore the safety, firmness and convenience of the fascia around the ischial spine as a new fixation site for the vaginal fornix. Methods Between June 2007 and January 2008, detailed dissections and related measurements of the regions around the ischial spine were performed on 10 Chinese female cadavers (3 unembalmed and 7 embalmed cadavers). At the same time, the sacrospinous ligament,the fascia on the ischial spine, the iliococcygeus fascia as well as the vaginal fornix were exposed and the pull-out strength sequentially tested using a digital push-pull force gauge. Results The fascia on the ischial spine was firm and strong, with a thickness of 3 about mm. No major vessels or nerves were observed on the ischial spine. The greatest pullout strengths of the sacrospinous ligament,the fascia on the ischial spine, the iliococcygeus fascia as well as the vaginal fornix were (102±26),(64±15),(33±8)and(32±6)N, respectively. Conclusion The fascia at 1 cm from anterior lateral ischial spine, free of major vessels and nerves, is safe and strong and could be used as a new site for suspension in vaginal prolapse.     

基于网络药理学探讨黄芪-川芎药对对糖尿病周围神经病变作用机制的研究

目的系统探讨黄芪-川芎(QX)药对治疗糖尿病周围神经病变(DPN)的关键靶点及作用机制。方法通过中药系统药理学分析平台(TCMSP)检索黄芪-川芎的主要有效成分及作用靶点,通过GeneCard数据库检索DPN的主要靶点,然后通过R语言绘制Venn图得出QX治疗DPN的共同靶点;利用Cytoscape 3.7.1软件构建中药-成分-疾病-靶点调控网络,然后通过String数据平台建立PPI网络,最后利用Bioconductor平台和R语言进行GO富集分析和KEGG通路分析。结果 QX中发挥治疗DPN的成分主要是槲皮素、山柰酚、叶酸、谷甾醇等19个活性成分;发挥治疗作用的靶点可能包括PTGS2、NOS2等69个关键靶点;影响治疗DPN的生物学过程主要为细胞因子活性、细胞因子受体结合等93个条目;发挥治疗的关键作用通路包括AGE-RAGE信号通路、IL-17通路等143个通路。结论 QX对DPN的治疗作用体现了中药多成分-多靶点-多通路的特点,提示其作用机制可能是通过多成分、多靶点、多通路实现,为进一步探讨QX对DPN的治疗和作用机制提供了思路和依据。     

坐骨棘筋膜固定术的临床解剖学研究

Objective The study was to explore the safety, firmness and convenience of the fascia around the ischial spine as a new fixation site for the vaginal fornix. Methods Between June 2007 and January 2008, detailed dissections and related measurements of the regions around the ischial spine were performed on 10 Chinese female cadavers (3 unembalmed and 7 embalmed cadavers). At the same time, the sacrospinous ligament,the fascia on the ischial spine, the iliococcygeus fascia as well as the vaginal fornix were exposed and the pull-out strength sequentially tested using a digital push-pull force gauge. Results The fascia on the ischial spine was firm and strong, with a thickness of 3 about mm. No major vessels or nerves were observed on the ischial spine. The greatest pullout strengths of the sacrospinous ligament,the fascia on the ischial spine, the iliococcygeus fascia as well as the vaginal fornix were (102±26),(64±15),(33±8)and(32±6)N, respectively. Conclusion The fascia at 1 cm from anterior lateral ischial spine, free of major vessels and nerves, is safe and strong and could be used as a new site for suspension in vaginal prolapse.     

不同工艺制得蒿甲醚pH依赖型固体分散体的比较研究

目的应用不同工艺制备蒿甲醚/HPMCAS(HF)固体分散体,通过含量、溶出度、收率的测定,阐明蒿甲醚pH依赖型固体分散体的最优制备工艺。方法以醋酸羟丙甲纤维素琥珀酸酯HPMCAS(HF)为固体分散体载体,通过3种工艺(共沉淀法、溶剂蒸发法及喷雾干燥法)制备蒿甲醚/HPMCAS(HF)固体分散体。考察其含量、收率以及在PH6.8和PH7.6环境下溶出度。结果原型药物及物理混合物溶出度均较低,喷雾干燥法制备的药物含量测定和收率都符合要求,在PH7.6的环境下能在2 h内完全溶出,明显高于另外两种方法。结论喷雾干燥技术制备的固体分散体显著改善蒿甲醚的溶出,而且有较好的pH依赖性,更适合用以蒿甲醚pH依赖型固体分散体的制备及工业生产。     

变应性鼻炎的药物治疗策略

变应性鼻炎(allergic rhinitis,AR)是耳鼻咽喉科常见的疾病,也是重要的变态反应性疾病之一.全球AR患者超过5亿,我国大陆地区AR的患病率为4％～38％[1].AR在给患者生活质量造成严重影响的同时,亦给社会带来沉重的经济负担[2].