全文获取类型
收费全文 | 9275篇 |
免费 | 916篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 247篇 |
儿科学 | 532篇 |
妇产科学 | 296篇 |
基础医学 | 926篇 |
口腔科学 | 621篇 |
临床医学 | 1029篇 |
内科学 | 1693篇 |
皮肤病学 | 204篇 |
神经病学 | 641篇 |
特种医学 | 358篇 |
外科学 | 1948篇 |
综合类 | 58篇 |
一般理论 | 1篇 |
预防医学 | 441篇 |
眼科学 | 284篇 |
药学 | 573篇 |
中国医学 | 18篇 |
肿瘤学 | 327篇 |
出版年
2023年 | 170篇 |
2022年 | 130篇 |
2021年 | 292篇 |
2020年 | 236篇 |
2019年 | 262篇 |
2018年 | 485篇 |
2017年 | 379篇 |
2016年 | 516篇 |
2015年 | 496篇 |
2014年 | 532篇 |
2013年 | 980篇 |
2012年 | 471篇 |
2011年 | 476篇 |
2010年 | 560篇 |
2009年 | 301篇 |
2008年 | 210篇 |
2007年 | 120篇 |
2006年 | 296篇 |
2005年 | 208篇 |
2004年 | 131篇 |
2003年 | 128篇 |
2002年 | 144篇 |
2001年 | 200篇 |
2000年 | 172篇 |
1999年 | 212篇 |
1998年 | 163篇 |
1997年 | 142篇 |
1996年 | 174篇 |
1995年 | 103篇 |
1994年 | 124篇 |
1993年 | 103篇 |
1992年 | 81篇 |
1991年 | 76篇 |
1990年 | 62篇 |
1989年 | 52篇 |
1988年 | 52篇 |
1987年 | 28篇 |
1986年 | 42篇 |
1985年 | 41篇 |
1984年 | 41篇 |
1983年 | 47篇 |
1982年 | 43篇 |
1981年 | 37篇 |
1980年 | 33篇 |
1979年 | 33篇 |
1977年 | 25篇 |
1975年 | 23篇 |
1974年 | 27篇 |
1973年 | 29篇 |
1930年 | 26篇 |
排序方式: 共有10000条查询结果,搜索用时 171 毫秒
1.
目的 运用网络药理学方法及分子对接技术探讨黄芪干预腹膜纤维化的可能机制。方法 利用中药系统药理学数据库及分析平台(TCMSP)检索黄芪的主要化学成分及靶点,并补充文献报道相关药理作用的成分作为潜在活性成分。以"peritoneal fibrosis"为关键词分别在OMIM、Genecards获取目前已知的与腹膜纤维化相关的疾病靶点,后取两者的交集靶点;对交集基因通过STRING数据库与Cytoscape 3.7.2软件构建"药物-成分-靶点-疾病"网络及蛋白互作(PPI)网络并筛选核心网络。基于R软件使用Bioconductor生物信息软件对核心靶点进行GO及KEGG富集分析,最终采用AutoDock软件将主要有效成分与核心靶点进行分子对接,得出其结合能力。结果 筛选出20个黄芪活性成分及文献报道有相关药理作用4个, 457药物作用靶点,与674个腹膜纤维化病靶点取交集,得到86个共同靶点。GO功能富集分析提示黄芪拮抗腹膜纤维化主要参与了蛋白激酶B信号转导的调节、细胞对化学的应激反应、炎症反应的调节等通路; KEGG通路富集分析主要涉及调控肿瘤、磷脂酰肌醇-3-羟激酶-蛋白激酶B(PI3K-Akt)、晚期糖基化终末产物/晚期糖基化终末产物受体(AGE-RAGE)、人类巨细胞病毒感染、HIF-1信号通路等;分子对接结果显示关键靶点与活性成分具有较好的结合能力。结论 黄芪治疗腹膜纤维化的分子机制,可能与抑制炎症及氧化应激反应、调节多种信号通路等相关。 相似文献
2.
3.
4.
Increased arterial stiffness in young normotensive patients with Turner syndrome: associations with vascular biomarkers 下载免费PDF全文
5.
6.
7.
Meral T. Ercan Nedim C. M. Gülaldi Işil S. Ünsal Mehmet Aydin İrfan Peksoy Zafer Hasçelik 《Annals of nuclear medicine》1996,10(4):419-423
The present study evaluated99mTc(V) DMSA as an agent for the visualization of inflammatory lesions in comparison to99mTc(HI) DMSA and99mTc-HIG. All three radiopharmaceuticals were prepared with commercial kits.99mTc(V) DMSA was prepared at neutral pH by the addition of first bicarbonate and then pertechnetate to the kit contents. The labeling efficiency was 99% as determined by ITLC. Abscesses were induced by i.m. injection of 50 μl turpentine into the right thighs of 36 Swiss albino mice. Six days later 3.7 MBq of each radiopharmaceutical was i.v. administered to 12 mice. The mice were sacrificed at 1,3,6 and 24 h later. Scintigrams were obtained with a gamma camera. The abscesses were better visualized on scintigrams with99mTc(V) DMSA compared to99mTc(III) DMSA, starting at 1 h. The animals were dissected and the organs were removed, weighed and the radioactivity determined with a gamma counter. The abscess to other tissue ratios were higher with99mTc(V) DMSA than the other radiopharmaceuticals. The max. abscess/muscle ratios were 9.46 ± 3.20 (24 h), 4.19 ± 1.39 (6 h) and 5.98 ± 1.17 (24 h) and max. abscess/blood ratios were 6.22 ± 1.41, 4.09 ± 0.84 and 0.914 ± 0.351 all at 24 h for99mTc(V) DMSA,99mTc(III) DMSA and99mTc-HIG, respectively. Experimental arthritis was produced in 6 New Zealand white rabbits by intra-articular injection of ovalbumin. Four days later 37 MBq of99mTc(V) DMSA and99mTc-HIG were each i.v. administered to 3 rabbits. Scintigrams obtained at 1, 3, 6, and 24 h clearly demonstrated arthritic joints. ROFs over arthritic joints were compared to contralateral normal joints (A/C). The max. A/C ratios were 2.10 ± 0.31 (3 h) and 2.92 ± 0.99 (24 h) for99mTc(V) DMSA and99mTc-HIG, respectively. Our results indicated the feasibility of imaging inflammatory lesions with99mTc(V) DMSA. 相似文献
8.
Summary Split or full thickness eyelid defects resulting from tumor destruction or surgical excision present a dilemma for plastic and reconstructive surgeons. Full thickness eyelid replacement requires composite grafting of the skin, together with tarsal support of its substitute and mucosa. The flap described by Fricke in 1829 was used for reconstruction of anterior lamella in six lower eyelid defects. In three of our cases chondromucosal grafts taken from nasal septum were utilized for posterior lamella repair. The results have been satisfactory from a functional and cosmetic standpoint. 相似文献
9.
Å. Öst P. Lindström B. Christensson H. Gyllenhammar L. Engstedt 《European journal of haematology》1984,33(2):160-170
A consecutive series of patients (1978–1981) comprising all patients with acute leukaemia from a population of 475000 inhabitants was reviewed. Thus, 94 patients were diagnosed as having acute leukaemia. No patients were lost from follow-up. The incidence figures of ALL and AML differed significantly from those of Sweden as a whole. 9 patients were < 15 years old. The median age of adult patients was 64 years, 60.8% being ≥ 60 years old. Of adult patients with AML, 20% had a preleukaemic history (chronic myeloproliferative disorders, myelodysplastic syndromes and others). None of 6 patients with leukaemia as a metamorphosis of a chronic myeloproliferative disorder achieved a complete remission. The overall remission rate of the remaining adult patients was 25%. Treated patients, 15–39 years old, with AML without any preleukaemic history, had a complete remission rate of 80% compared to 12% for patients ≥ 60 years old with the same diagnosis. Of 60 patients with ‘primary’ AML, 14 were not treated, mainly because of advanced age and complicating diseases. Most of these patients died within a week of admission. 相似文献
10.