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排序方式: 共有631条查询结果,搜索用时 15 毫秒
1.
Formulation and in Vitro-in Vivo Evaluation of Sustained-Release Lithium Carbonate Tablets 总被引:1,自引:0,他引:1
Çiftçi Kadriye Çapan Yilmaz Öztürk Orhan Hincal A. Atilla 《Pharmaceutical research》1990,7(4):359-363
The release of lithium carbonate incorporated into polymethylmethacrylate, poly vinyl chloride, hy-drogenated vegetable oil, and carbomer matrix tablets was studied in vitro. The formulation containing 10% carbomer showed a sustained-release profile comparable to that of a standard, commercially available, sustained-release preparation containing 400 mg lithium carbonate embedded in a composite material. In vivo the newly formulated and standard sustained-release lithium carbonate tablets were compared to an oral solution and conventional lithium carbonate tablets in 12 healthy subjects. These crossover studies showed that the sustained-release tablets produced a flatter serum concentration curve than the oral solution and conventional tablet, without loss of total bioavailability. 相似文献
2.
Effects of granulocyte colony-stimulating factor on bacterial translocation due to burn wound sepsis
Orhan Yalçin Gürsel Soybir Ferda Köksoy Hakki Köse Recep Öztürk Baki Çokne§eli 《Surgery today》1997,27(2):154-158
The presence of certain defects in both cellular and humoral immunity after thermal injury has been established. Likewise,
the translocation of enteric bacteria to the mesenteric lymph nodes and to distant organs has also been observed following
serious thermal injury. The effects of granulocyte colony-stimulating factor (G-CSF) on bacterial translocation, the small
bowel mucosa, and cecal bacterial content were investigated in a rat model of burn wound sepsis in which albino Wistar rats
were scalded over 30% of their bodies, after which the lesions were infected by 1×108 colony-forming units (cfu)Pseudomonas aeruginosa. The control group was treated with 5% dextrose solution subcutaneously starting 2 days preburn, while the treatment group
received 100μg/kg human G-CSF subcutaneously. On the 4th day post burn all animals were killed to examine the bowel and culture
of the mesenteric lymph nodes (MLN), livers, and spleens. No significant differences were observed between the groups regarding
the cecal bacterial content and small bowel; however, a difference was seen in the ratio of translocation in the MLN liver
and spleen and quantitative MLN cultures. Based on these findings, G-CSF was thus found to be significantly effective in reducing
bacterial translocation due to burn wound sepsis. 相似文献
3.
Abdominal Stab Wounds in Children: an 18-Year Experience 总被引:1,自引:0,他引:1
Hayrettin ?ztürk Abdurrahman Onen Selcuk Ot?u Ali hsan Dokucu Yusuf Yamur Senol Gedik 《European Journal of Trauma》2002,28(2):85-89
Objective: Evaluation of the diagnosis, management, and the role of selective treatment in children with abdominal stab wounds.
Patients and Methods: 59 children (56 male and three female) were included in the study. The patients' median age was 11.8 years (range, 5–14 years).
Time between injury and admission was about 3 h. Laparotomy was performed in 44 patients (74%). Solid organ injury was detected
in 32 of these patients (73%) and could not be observed in twelve (27%). 15 patients (26%) were treated conservatively, and
only one (6.6%) underwent laparotomy during the follow-up. The stomach was the most frequently injured organ (ten patients),
followed by the intestines (nine patients). Types of surgical treatment were as follows: primary suture in 28 patients, resection-anastomosis
in three, and osteotomy in two.
Results: Some prognostic factors such as presence of abdominal organ evisceration and pneumoperitoneum were not significantly correlated
with intraabdominal organ injury, whereas some other risk factors such as acute abdomen on admission (p < 0.002) or abdominal
clinical and hemodynamic findings (p < 0.001) showed significant correlation with intraabdominal organ injury. The relative
risk (odds ratio) of developing an intraabdominal organ injury was > 2 for patients with signs of an acute abdomen on admission.
Postoperative complications were observed in five patients with organ injuries. None of our patients died.
Conclusions: Conservative treatment can be safely performed in most children with abdominal stab injuries. Signs of major internal hemorrhage
or generalized peritonitis are an absolute indication for emergency operation for abdominal stab wounds. Peritoneal penetrations,
free air on the abdominal X-ray, and omental or intestinal evisceration are poor indicators of significant organ injuries,
and patients presenting these signs shold be closely followed up for developing acute abdominal symptoms.
Received: November 2, 2001; revision accepted: February 15, 2002 相似文献
4.
Deniz Eyice Karabacak Semra Demir Osman Ozan Yeğit Ali Can Kadriye Terzioğlu Derya Ünal Müge Olgaç Raif Coşkun Bahauddin Çolakoğlu Suna Büyüköztürk Aslı Gelincik 《Allergy》2021,76(8):2535-2543
Background
Hereditary angioedema (HAE) attacks can be provoked with psychological factors. The aim of this study was to assess the effects of anxiety, depression and stress related to COVID-19 pandemic on disease activity of HAE patients during the quarantine period (QP) and the return to normal period (RTNP).Methods
This study was conducted between March 2020 and September 2020 in four allergy centres. Demographic, clinical features and mental health status were evaluated in QP (from March to the beginning of June) and RTNP (from June to the beginning of September) applied by the government. The 10-point visual analogue scale (VAS10) was used to define the severity of HAE attacks. Depression, Anxiety and Stress Scales-21 (DASS-21) and Fear of COVID-19 (FC-19) scale were performed to assess mental health status.Results
139 HAE patients were included in the study. In QP, median attack numbers and median VAS10 scores were 5 (min-max: 0–45) and 6 (min-max: 0–10), respectively. HAE attack numbers, DASS-21 stress, anxiety, depression and total DASS-21 scores, and FC-19 scores were higher in QP than RTNP (p = 0.001, p < 0.001, p = 0.001, p < 0.001, p < 0.001, p < 0.001, respectively). However, there was no difference in attack severity scores between the two periods (p > 0.05).Conclusions
This study revealed that the restriction measures during COVID-19 outbreak cause an increase in the number of HAE attacks in relation to anxiety, depression, stress and fear of COVID-19 pandemic. Therefore, it is important to provide psychological support to HAE patients during the pandemic.5.
A. Tümer N. Öztürk-Demir C. Basar-Eroglu A. Noyan 《Journal of muscle research and cell motility》1983,4(1):103-113
Summary In this study the spontaneous activities of prescapular lymph nodes, which were isolated from calves, goats and sheep and mesenteric lymph nodes of guinea-pigs were recorded and analysed in the frequency domain. Stretch-evoked contractions of the mesenteric lymph nodes were also recorded and their frequency characteristics analysed.The preparations were placed in a Krebs solution which was kept at 37° C and bubbled continuously with a mixture of 95% O2 and 5% CO2. The tension changes occurring in the lymph nodes were recorded. The patterns obtained were initially transformed into numerical values which were then used to obtain autocorrelation functions and power spectra, according to the time series analysis method. A passive stretch of 100 s duration was applied to the mesenteric lymph nodes and the responses were examined using the transient response-frequency characteristics method.It was observed that prescapular and mesenteric lymph nodes had spontaneous activities due to the contractions of the smooth muscles within the nodes. A frequency analysis of these contractions indicated that at least three contractile components were responsible for the contractions; these components contract within the frequency bands of 0.01–0.04 Hz, 0.05–0.07 Hz and 0.09–0.14 Hz respectively. It was also observed that the spontaneous activities could be regulated and synchronized by stretch. It is suggested that these contractions of the lymph nodes play an essential role in lymph propulsion within the nodes. 相似文献
6.
7.
TAŞ Beray Gelmez Özceylan Gökmen Öztürk Güzin Zeren Toprak Dilek 《Journal of community health》2021,46(4):777-785
Journal of Community Health - The purpose of this study was to evaluate family physicians’ job strain during the Covid-19 pandemic and determine the effective factors. The study was carried... 相似文献
8.
Dokucu AI Ozdemir E Oztürk H Otçu S Onen A Ciğdem K Kaya M Bükte Y Yücesan S 《International urology and nephrology》2000,32(1):3-8
We analysed the inter-relationships of the cause and the type of trauma, the presence of pelvic fracture, the associated intraabdominal
organ injuries,and the morbidity and mortality rates in 154 patients presenting and being treated for UGT between 1983 and
1997.The cause of injury was blunt in 77% of cases and penetrating in 13%. The most frequently injured organs were kidney
followed by urethra and bladder. Bowels, liver and spleen were the most frequently associated injured organs. Moreover, bladder
injuries were strongly associated with bowel injuries (p < 0.0001). Hemodynamically normal 49 children with minor or major kidney injuries were managed conservatively. Hemodynamically
non-stable 11 patients were explored.The majority of urogenital injuries can be managed conservatively evenwhen associated
with intraabdominal organ injuries. Solid genitourinary organ injuries may accompany more frequently to intraperitoneal solidorgan
injury. Whereas, non-solid genitourinary organ injuries may more frequently associated with injuries of intraperitoneal hollow
viscus.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
9.
Kounis syndrome is a life-threatening medical condition that causes severe allergic reaction and acute coronary syndrome. Benzathine penicillin G is one of the most widely used antibiotics in clinical practice, but it can enhance both allergic and hypersensitivity complications. In this report, we describe the case of a 42-year-old man admitted to our hospital who presented with cryptic tonsillitis accompanied by angioneurotic edema, chest pain, and electrocardiographic variations. The patient was diagnosed with Kounis syndrome and treated with oral antihistamines and prednisolone. He was discharged following a complete recovery and regression of electrocardiographic abnormalities within 72 hours. 相似文献
10.
Meryem Elif Öztürk 《Ecology of food and nutrition》2018,57(1):3-12
Recent studies have shown that poor sleep quality is significantly associated with obesity. The aim of this study is to examine the association of sleep quality with obesity and specific anthropometric measurements. A total of 105 women aged 20–55 years with no chronic diseases participated in this study. They filled out the Pittsburgh Sleep Quality Index (PSQI), their anthropometric measurements were taken, and their dietary data were collected with a food frequency questionnaire (FFQ). There was no significant relationship between sleep quality and BMI, waist circumference, triceps skinfold thicknesses, body fat ratio (%), and body fat mass (p > .05), but high bread consumption was significantly associated with poor sleep quality (p < .05). The women with poor sleep quality consumed significantly more bread, but not other foods, than the women with good sleep quality. Sleep quality can thus be related to eating habits. 相似文献