全文获取类型
收费全文 | 1100篇 |
免费 | 64篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 55篇 |
妇产科学 | 62篇 |
基础医学 | 80篇 |
口腔科学 | 106篇 |
临床医学 | 84篇 |
内科学 | 242篇 |
皮肤病学 | 11篇 |
神经病学 | 52篇 |
特种医学 | 47篇 |
外科学 | 294篇 |
综合类 | 16篇 |
预防医学 | 15篇 |
眼科学 | 16篇 |
药学 | 46篇 |
中国医学 | 4篇 |
肿瘤学 | 22篇 |
出版年
2024年 | 2篇 |
2023年 | 9篇 |
2022年 | 19篇 |
2021年 | 41篇 |
2020年 | 26篇 |
2019年 | 30篇 |
2018年 | 30篇 |
2017年 | 39篇 |
2016年 | 45篇 |
2015年 | 60篇 |
2014年 | 68篇 |
2013年 | 70篇 |
2012年 | 132篇 |
2011年 | 101篇 |
2010年 | 45篇 |
2009年 | 52篇 |
2008年 | 95篇 |
2007年 | 90篇 |
2006年 | 63篇 |
2005年 | 59篇 |
2004年 | 41篇 |
2003年 | 30篇 |
2002年 | 18篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 3篇 |
1996年 | 1篇 |
1990年 | 2篇 |
排序方式: 共有1174条查询结果,搜索用时 15 毫秒
1.
2.
3.
Estrogens have long been known to be important for skeletal homeostasis, but their precise mechanisms of action in bone are still unclear. Mice with targeted deletions of the estrogen receptors alpha (ERalpha) and beta (ERbeta) have been generated by two research groups and several studies performed characterizing the phenotype of ERalpha knockout (ERKOalpha), ERbeta knockout (ERKObeta), or double deletion of ERalpha and ERbeta (DERKO) mice. Initial studies reported a reduction in bone mineral density in male ERKOalpha mice. More extensive analyses have been puzzling, likely because of compensatory mechanisms in ERKO mice. Furthermore, the existence of a third ER continues to be a potential explanation for some actions of estrogen in bone. Other rodent models, including the testicular feminized mouse and rat, the aromatase knockout mouse, and a rat with a dominant negative ER mutation, have added information regarding estrogen's actions in bone. This review summarizes many reports characterizing available rodent models with genetic alterations relevant to estrogen action. The sum of these reports suggests that the ERbeta is not highly protective in bone because loss of its function results in minimal alterations in the skeleton. Furthermore, loss of both the ERalpha and the ERbeta does not account for loss of estrogen action in bone, because the impact of DERKO is seemingly not as great as the impact of gonadectomy on the skeleton. Finally, through studies of ERKO mice and other rodent models of altered sex steroid action, it appears that estrogen may be more protective in the skeleton than androgens. 相似文献
4.
5.
Neriman Sila Koc Rahmi Yilmaz Tolga Yildirim Gonca Eldem Bora Peynircioglu Yunus Erdem 《Transplantation proceedings》2021,53(3):1010-1013
Secondary hyperparathyroidism is one of the most common complications of chronic kidney failure. If prolonged, parathyroid hormone release gains autonomy and tertiary hyperparathyroidism with parathyroid adenoma or hyperplasia can be develop. Tertiary hyperparathyroidism is associated with increased risk of mortality and morbidity; thus, treatment is recommended. Medical treatment includes phosphate binders, vitamin D analogues, and calcimimetic agents. Most cases of tertiary hyperparathyroidism can be controlled with medical treatment. When medical treatment options prove insufficient, parathyroidectomy is recommended. However, recurrence after parathyroidectomy is possible, which requires an alternative treatment. We present our percutaneous embolization experience, which has not been tried in the treatment of tertiary hyperparathyroidism in renal transplantation patients diagnosed with tertiary hyperparathyroidism. 相似文献
6.
Julia A Knight U Venus Onay Sean Wells Hong Li Ellen J Q Shi Irene L Andrulis Hilmi Ozcelik 《Cancer epidemiology, biomarkers & prevention》2004,13(1):146-149
There are several genes that code for enzymes, including various forms of superoxide dismutase and glutathione peroxidase, that protect the cell against oxidative damage that, in turn, can lead to carcinogenesis. There are a few common genetic polymorphisms in these genes that lead to altered proteins. Three that have been identified are SOD2 Val-9Ala, GPX1 Pro198Leu, and the GPX1 GCG repeat (three alleles with four, five, or six repeats). The SOD2 variant has been associated with increased breast cancer risk in two studies. The GPX1 variants have not been studied with respect to breast cancer, but Pro198Leu has been associated with lung cancer. We conducted a case-control study of these three polymorphisms in incident, invasive breast cancer in Caucasian women under 55. There were 399 cases and 372 controls genotyped, of whom 488 were premenopausal, 208 postmenopausal, and 75 of unknown menopausal status. We were unable to replicate the previously observed association with SOD2 Val-9Ala and also found no association between breast cancer and GPX1 Pro198Leu. However, the allele of GPX1 containing four GCG repeats was significantly associated with breast cancer risk in premenopausal women (odds ratio, 1.55; 95% confidence interval, 1.04-2.30 for carriers versus noncarriers). There is a significant trend of increasing risk with increasing number of alleles with four GCG repeats (P = 0.03). This variant has not previously been reported to be associated with breast cancer. 相似文献
7.
8.
Incremental value of live/real time three‐dimensional transesophageal echocardiography over the two‐dimensional technique in the assessment of a tuberculoma involving the left atrium and appendage
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Tuğba Kemaloğlu Öz M.D. Mahmoud Elsayed M.B.B.Ch Navin C. Nanda M.D. Koray Kalenderoğlu M.D. Şükrü Akyüz M.D. Işıl Atasoy M.D. Altuğ Ösken M.D. Tolga Onuk M.D. Mehmet Eren M.D. 《Echocardiography (Mount Kisco, N.Y.)》2016,33(9):1409-1412
Intracardiac tuberculomas are extremely rare, and cardiac involvement in tuberculosis accounts for only 0.5% of extrapulmonary tuberculosis. We report for the first time incremental value of live/real time three‐dimensional transesophageal echocardiography over two‐dimensional transesophageal echocardiography in the assessment of a tuberculoma involving the left atrium and left atrial appendage. 相似文献
9.
Renal complications of lipodystrophy: A closer look at the natural history of kidney disease
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Baris Akinci Sadiye Mehtat Unlu Ali Celik Ilgin Yildirim Simsir Sait Sen Banu Nur Fatma Ela Keskin Basak Ozgen Saydam Nilufer Kutbay Ozdemir Banu Sarer Yurekli Bekir Ugur Ergur Melda Sonmez Tahir Atik Atakan Arslan Tevfik Demir Canan Altay Ulku Aybuke Tunc Tugba Arkan Ramazan Gen Erdal Eren Gulcin Akinci Aslihan Arasli Yilmaz Habib Bilen Samim Ozen Aygul Celtik Senay Savas Erdeve Semra Cetinkaya Huseyin Onay Sulen Sarioglu Elif Arioglu Oral 《Clinical endocrinology》2018,89(1):65-75
10.
Reliability of Charcot’s triad has long been questioned. Tokyo Guidelines committee published Tokyo Guidelines in 2007 and 2013. The aim of this study was to retrospectively examine the patients who had been treated with the diagnosis of acute cholangitis and evaluate 2007–2013 Tokyo criteria and Charcot’s triad. The files of the patients with acute cholangitis in a referral center were examined retrospectively. All patients were classified and evaluated according to 2007 and 2013 Tokyo criteria and Charcot’s triad; and results were compared. It was detected that 51.7 % of patients who did not meet Charcot’s triad were in definitive diagnosis group of both Tokyo criteria. Kappa value was calculated as 0.404 in the analysis of consistency between two Tokyo criteria. Two patients who had features sufficient to objectively make the diagnosis of acute cholangitis failed to meet the Tokyo criteria 2007 or 2013. Charcot’s triad is not sensitive and specific enough in the diagnosis of acute cholangitis. Revision of Tokyo 2007 criteria caused a change in the diagnostic status of 15 % of the patients. It is remarkable that kappa value can hardly be considered as a sign of moderate agreement between two Tokyo guidelines. Tokyo criteria should be supported and updated. 相似文献