全文获取类型
收费全文 | 219333篇 |
免费 | 44419篇 |
国内免费 | 367篇 |
专业分类
耳鼻咽喉 | 3643篇 |
儿科学 | 8595篇 |
妇产科学 | 3716篇 |
基础医学 | 34067篇 |
口腔科学 | 9409篇 |
临床医学 | 21446篇 |
内科学 | 57880篇 |
皮肤病学 | 11369篇 |
神经病学 | 24315篇 |
特种医学 | 5436篇 |
外国民族医学 | 1篇 |
外科学 | 30474篇 |
综合类 | 797篇 |
一般理论 | 64篇 |
预防医学 | 18340篇 |
眼科学 | 4276篇 |
药学 | 15187篇 |
中国医学 | 1684篇 |
肿瘤学 | 13420篇 |
出版年
2023年 | 974篇 |
2022年 | 1059篇 |
2021年 | 4505篇 |
2020年 | 6599篇 |
2019年 | 13981篇 |
2018年 | 14809篇 |
2017年 | 13798篇 |
2016年 | 14317篇 |
2015年 | 14602篇 |
2014年 | 15245篇 |
2013年 | 17722篇 |
2012年 | 14281篇 |
2011年 | 14894篇 |
2010年 | 14121篇 |
2009年 | 9278篇 |
2008年 | 10874篇 |
2007年 | 10276篇 |
2006年 | 9736篇 |
2005年 | 9444篇 |
2004年 | 8444篇 |
2003年 | 8013篇 |
2002年 | 7610篇 |
2001年 | 4807篇 |
2000年 | 5410篇 |
1999年 | 3817篇 |
1998年 | 753篇 |
1997年 | 555篇 |
1996年 | 516篇 |
1995年 | 428篇 |
1994年 | 316篇 |
1993年 | 293篇 |
1992年 | 1399篇 |
1991年 | 1143篇 |
1990年 | 1027篇 |
1989年 | 839篇 |
1988年 | 692篇 |
1987年 | 671篇 |
1986年 | 676篇 |
1985年 | 574篇 |
1984年 | 431篇 |
1983年 | 332篇 |
1979年 | 362篇 |
1975年 | 287篇 |
1974年 | 335篇 |
1973年 | 370篇 |
1972年 | 305篇 |
1971年 | 316篇 |
1970年 | 296篇 |
1969年 | 302篇 |
1968年 | 275篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
Mette Nissen Tiina‐Mari Ikheimo Jukka Huttunen Ville Leinonen Henna‐Kaisa Jyrkknen Mikael von und zu Fraunberg 《Neuromodulation》2021,24(1):102-111
ObjectiveSpinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). We studied the effect of preimplantation opioid use on SCS outcome and the effect of SCS on opioid use during a two-year follow-up period.Materials and methodsThe study cohort included 211 consecutive FBSS patients who underwent an SCS trial from January 1997 to March 2014. Participants were divided into groups, which were as follows: 1) SCS trial only (n = 47), 2) successful SCS (implanted and in use throughout the two-year follow-up period, n = 131), and 3) unsuccessful SCS (implanted but later explanted or revised due to inadequate pain relief, n = 29). Patients who underwent explantation for other reasons (n = 4) were excluded. Opioid purchase data from January 1995 to March 2016 were retrieved from national registries.ResultsHigher preimplantation opioid doses associated with unsuccessful SCS (ROC: AUC = 0.66, p = 0.009), with 35 morphine milligram equivalents (MME)/day as the optimal cutoff value. All opioids were discontinued in 23% of patients with successful SCS, but in none of the patients with unsuccessful SCS (p = 0.004). Strong opioids were discontinued in 39% of patients with successful SCS, but in none of the patients with unsuccessful SCS (p = 0.04). Mean opioid dose escalated from 18 ± 4 MME/day to 36 ± 6 MME/day with successful SCS and from 22 ± 8 MME/day to 82 ± 21 MME/day with unsuccessful SCS (p < 0.001).ConclusionsHigher preimplantation opioid doses were associated with SCS failure, suggesting the need for opioid tapering before implantation. With continuous SCS therapy and no explantation or revision due to inadequate pain relief, 39% of FBSS patients discontinued strong opioids, and 23% discontinued all opioids. This indicates that SCS should be considered before detrimental dose escalation. 相似文献
3.
4.
5.
Vilar-Compte Mireya Gaitán-Rossi Pablo Félix-Beltrán Lucía Bustamante Arturo V. 《Journal of immigrant and minority health / Center for Minority Public Health》2022,24(1):65-77
Journal of Immigrant and Minority Health - COVID-19 has disproportionally affected underrepresented minorities (URM) and low-income immigrants in the United States. The aim of the study is to... 相似文献
6.
Troppmair Teresa Egger J. Krösbacher A. Zanvettor A. Schinnerl A. Neumayr A. Baubin M. 《Der Anaesthesist》2022,71(4):272-280
Die Anaesthesiologie - Die Qualität eines Rettungssystems zeichnet sich auch durch den effizienten Einsatz seiner personellen und Fahrzeugressourcen aus. So können im berechtigten Fall... 相似文献
7.
8.
9.
10.
Ali Mobasheri Csaba Matta Ilona Uzielienè Emma Budd Pablo Martín-Vasallo Eiva Bernotiene 《Joint, bone, spine : revue du rhumatisme》2019,86(1):29-35
Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal and ECM proteins and other macromolecular complexes. The chondrocyte channelome is a sub-compartment of the membranome and includes a complete set of ion channels and porins expressed in these cells. Many of these are multi-functional proteins with “moonlighting” roles, serving as channels, receptors and signalling components of larger molecular assemblies. The aim of this review is to summarise our current knowledge of the fundamental aspects of the chondrocyte channelome, discuss its relevance to cartilage biology and highlight its possible role in the pathogenesis of osteoarthritis (OA). Excessive and inappropriate mechanical loads, an inflammatory micro-environment, alternative splicing of channel components or accumulation of basic calcium phosphate crystals can result in an altered chondrocyte channelome impairing its function. Alterations in Ca2+ signalling may lead to defective synthesis of ECM macromolecules and aggravated catabolic responses in chondrocytes, which is an important and relatively unexplored aspect of the complex and poorly understood mechanism of OA development. 相似文献