全文获取类型
收费全文 | 3285篇 |
免费 | 192篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 57篇 |
儿科学 | 39篇 |
妇产科学 | 3篇 |
基础医学 | 343篇 |
口腔科学 | 47篇 |
临床医学 | 261篇 |
内科学 | 1302篇 |
皮肤病学 | 54篇 |
神经病学 | 239篇 |
特种医学 | 84篇 |
外科学 | 480篇 |
综合类 | 13篇 |
预防医学 | 55篇 |
眼科学 | 41篇 |
药学 | 231篇 |
中国医学 | 5篇 |
肿瘤学 | 264篇 |
出版年
2023年 | 18篇 |
2022年 | 47篇 |
2021年 | 94篇 |
2020年 | 49篇 |
2019年 | 81篇 |
2018年 | 84篇 |
2017年 | 70篇 |
2016年 | 83篇 |
2015年 | 72篇 |
2014年 | 113篇 |
2013年 | 142篇 |
2012年 | 215篇 |
2011年 | 243篇 |
2010年 | 139篇 |
2009年 | 113篇 |
2008年 | 215篇 |
2007年 | 219篇 |
2006年 | 203篇 |
2005年 | 205篇 |
2004年 | 176篇 |
2003年 | 166篇 |
2002年 | 157篇 |
2001年 | 58篇 |
2000年 | 74篇 |
1999年 | 77篇 |
1998年 | 37篇 |
1997年 | 28篇 |
1996年 | 16篇 |
1995年 | 13篇 |
1994年 | 15篇 |
1993年 | 12篇 |
1992年 | 25篇 |
1991年 | 22篇 |
1990年 | 25篇 |
1989年 | 22篇 |
1988年 | 16篇 |
1987年 | 23篇 |
1986年 | 25篇 |
1985年 | 28篇 |
1984年 | 16篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1975年 | 7篇 |
1973年 | 5篇 |
1972年 | 4篇 |
1971年 | 4篇 |
排序方式: 共有3518条查询结果,搜索用时 15 毫秒
1.
2.
Kazumasa Miyake Atsushi Tatsuguchi Mikiko Tachibana Masanobu Kusunoki Yoko Shinji Kei Shinoki Tetsuro Hiratsuka Kazuhiro Nagata Hitoshi Nishigaki Seiji Futagami Ken Wada Taku Tsukui Toshiro Yoshiyuki Akira Tokunaga Takashi Tajiri Choitsu Sakamoto 《Digestive endoscopy》2004,16(2):172-175
A 52‐year‐old Japanese woman who presented with gastrointestinal (GI) bleeding underwent a proximal gastrectomy for a gastrointestinal stromal tumor (GIST) with a foveolar hyperplasia at the apex of the tumor, 4.5 cm in size, located in the upper body of the stomach. Although GIST are often asymptomatic and are found only incidentally, clinical symptoms such as bleeding, abdominal pain, or obstruction, occasionally lead to a premorbid diagnosis. When submucosal tumors present GI bleeding, the source of the bleeding usually is an ulceration of the mucosa over the tumor. However, in the present study, it was thought that the bleeding originated from the region of foveolar hyperplasia. 相似文献
3.
Kazuhisa Miyashita Akihiro Tojo Kenjiro Kimura Atsuo Goto Masao Omata Keisuke Nishiyama Toshiro Fujita 《Hypertension research》2004,27(2):79-84
Recombinant human erythropoietin (rHuEPO) has been reported to induce hypertension. We investigated the effect of a single injection of rHuEPO on blood pressure in patients receiving hemodialysis (HD) and in patients with predialysis chronic renal failure (CRF). Forty-one patients receiving HD and 36 patients with predialysis CRF received an intravenous injection of rHuEPO, and blood pressure and plasma endothelin-1 were measured before and 30 min after the injection. Mean blood pressure was increased significantly in HD patients, but not in CRF patients (HD: 103+/-5 to 105+/-6 mmHg, p<0.05; CRF: 103+/-4 to 103+/-6, NS). The percentage of patients with increased mean blood pressure of more than 10 mmHg after rHuEPO injection was significantly larger in the HD than in the CRF group (27.0% vs. 5.5%, p<0.01). A positive correlation was found between changes in endothelin-1 level and mean blood pressure in the HD (r=0.43, p<0.01) but not in predialysis chronic renal failure. In conclusion, a single injection of rHuEPO increased blood pressure with a positive correlation with endothelin-1 release in hemodialysis patients, but not in predialysis chronic renal failure patients. 相似文献
4.
F Omata Y Ichikawa Y Kushibiki H Shimizu M Yoshida M Komatsuda S Arimori 《American journal of hematology》1992,40(2):160-161
5.
M Yasujima K Abe M Kohzuki M Tanno Y Kasai M Sato K Omata K Kudo K Takeuchi K Yoshinaga 《Japanese circulation journal》1986,50(11):1185-1190
To assess the pathophysiological role of atrial natriuretic factors in the regulation of blood pressure, we studied the effect of chronic infusion of a synthetic atrial natriuretic factor of 25 amino-acid residues on blood pressure and sodium-water excretion. Experimental subjects were rats with hypertension made by chronic infusion of vasopressin on regular intakes of sodium or on sodium loading with 1% NaCl as drinking water. When a subdepressor dose (150 micrograms/kg/day) of synthetic atrial natriuretic factor was delivered via an osmotic minipump into the jugular vein simultaneously with 7.2 U/kg/day of vasopressin infused intraperitoneally by another osmotic minipump, the expected elevation of systolic blood pressure was completely inhibited. This was not accompanied by any changes in urine volume and urinary sodium excretion. The antihypertensive effect was sustained throughout the experimental period lasting 3 days in rats on regular sodium intake (p less than 0.01) or on sodium loading with 1% NaCl as drinking water (p less than 0.01). These results indicate that a subdepressor dose of synthetic atrial natriuretic factor can modulate the vasopressor effect of vasopressin. Therefore it is suggested that an atrial natriuretic factor may be involved in the regulation of blood pressure via its antagonizing effect to vasopressin. 相似文献
6.
Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantation. 总被引:4,自引:0,他引:4
Shintaro Yagi Taku Iida Kentaro Taniguchi Tomohide Hori Takashi Hamada Koji Fujii Shugo Mizuno Shinji Uemoto 《Liver transplantation》2005,11(1):68-75
Several reports claim that portal hypertension after living-donor liver transplantation (LDLT) adversely affects graft function, but few have assessed the impact of portal venous pressure (PVP) on graft regeneration. We divided 32 adult LDLT recipients based on mean PVP during the 1st 3 days after LDLT into a group with a PVP > or = 20 mm of Hg (H Group; n = 17), and a group with a PVP < 20 mm of Hg (L Group; n = 15). Outcome in the H Group was poorer than in the L Group (58.8 vs. 92.9% at 1 year). Peak peripheral hepatocyte growth factor (HGF) during the 1st 2 weeks was higher in the H Group (L: 1,730 pg/mL, H: 3,696 pg/mL; P < .01), whereas peak portal vascular endothelial growth factor (VEGF) level during the 1st week was higher in the L Group (L: 433 pg/mL, H: 92 pg/mL; P < .05). Graft volume (GV) / standard liver volume (SLV) was higher in the H Group (L / H, at 2, 3, and 4 weeks, and at 3 months: 1.02 / 1.24, .916 / 1.16, .98 / 1.27, and .94 / 1.29, respectively; P < .05). Peak serum aspartate aminotransferase, bilirubin levels, and international normalized ratio after LDLT were significantly higher in the H Group, as was mean ascitic fluid volume. In conclusion, early postoperative PVP elevation to 20 mm of Hg or more was associated with rapid graft hypertrophy, higher peripheral blood HGF levels, and lower portal VEGF levels; and with a poor outcome, graft dysfunction with hyperbilirubinemia, coagulopathy, and severe ascites. Adequate liver regeneration requires an adequate increase in portal venous pressure and flow reflected by clearance of HGF and elevated VEGF levels. 相似文献
7.
8.
Shinya Kodashima Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Masanori Nakamura Masao Omata 《Digestive endoscopy》2006,18(2):151-153
Endoscopic resection has been accepted as the standard treatment for intramucosal gastric tumors of differentiated type. However, the indication was limited to small tumors to achieve en bloc resection and prevent local recurrence in cases of conventional endoscopic mucosal resection (EMR) such as the strip biopsy and the cap technique. To avoid multi‐fragmental resection, we have developed endoscopic submucosal dissection (ESD) as a new endoscopic resection technique. ESD is a remarkable technique, because we make it possible to remove the lesions en bloc regardless of size, shape, coexisting ulcer, and location. However, it is difficult or impossible to resect recurrent tumors en bloc in conventional EMR owing to hard fibrosis, and some patients need laparotomy. Using ESD, we can dissect the submucosal layer as we directly look at the submucosa, and remove the lesion safely and reliably even in cases of hard fibrosis. The key to treatment of recurrent tumors in ESD are as follows: (i) using enough submucosal injection solution (we use a mixture of Glyceol and 1% 1900 kDa hyaluronic acid preparation); (ii) incising the mucosa without fibrosis; (iii) understanding characteristics of various cutting devices, and changing other devices in difficult situations. In these ways we can remove the majority of the recurrent tumors en bloc. Hence, we consider that ESD is a very effective treatment which achieves excellent en bloc and complete resection rates and enables patients with intramucosal gastric tumors to a recurrent‐free survival even in recurrent tumors. 相似文献
9.
Yoichi Kikuchi Taku Sakurada Masato Suzuki Tomoyasu Hirano Katsuyuki Kusajima 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(8):375-378
Off-pump coronary artery bypass grafting has become an attractive surgical alternative for myocar-dial revascularization because
of the advantage of myocardial protection and other benefits of patients. However, it is still regarded as a controversial
treatment for the coronary artery disease accompanied by atrial fibrillation (AF). A significant number of patients in need
of coronary revascularization have chronic AF. Although the Cox-Maze III procedure is the gold standard for the surgical treatment
of AF, few of these patients undergo AF operations at the time of their coronary bypass grafting. We report herein a case
of the pulmonary vein isolation to eliminate the AF by means of epicardial radiofrequency ablation combined with 2 vessels
coronary artery bypass grafting on the beating heart with the aid of cardiopulmonary bypass. 相似文献
10.