19Electrogastrography differentiates enteric myopathy from neuropathy in adults with severe motility disorders of the gut

Background:  Chronic intestinal pseudo-obstruction, enteric dysmotility and slow transit constipation are severe motility disorders of the gut that usually are associated with an underlying enteric neuropathy or myopathy. Electrogastrography (EGG) is a non-invasive technique that records gastric myoelectric activity.
Aim of the study:  To determine whether EGG can differentiate enteric myopathy from neuropathy as the primary pathology in patients with severe motility disorders of the gut.
Material and methods:  This is a retrospective analysis of patients with various motility disorders of the gut that underwent full thickness small bowel biopsy. A single bipolar channel measured the EGG. The ability of EGG to differentiate between myopathy and neuropathy was tested by comparing 21 variables from EGG.
Results:  A total of 38 patients, 35 (92%) females, mean age 42 ± 13 years, were analysed. Twenty patients had enteric dysmotility (19 with neuropathy and one with myopathy), 12 had slow transit constipation (10 with neuropathy and two with myopathy), and six had chronic intestinal pseudo-obstruction (three with neuropathy and three with myopathy). Patients with myopathy showed higher percentage of fasting time with DF in bradygastric and tachygastric frequency bands and a higher postprandial DF (Table) than did patients with neuropathic motility disorders.
Conclusions:  Patients with visceral myopathy exhibited more arrhythmia during fasting and a higher DF following the test meal and this indicates that myopathies are associated with more electrical disturbances than neuropathies. EGG may be considered for differentiating between these two disease entities.
 

     

3.

Detection of acute myocardial infarction by a new, sensitive and rabid method for determination of creatine kinase B-subunit activity     

LINDBERG  L.; LINDIN  A.; NORDLANDER  R.; NYQUIST  O.; STYRELIUS  I. 《European heart journal》1980,1(5):327-333

An immunoinhibition method for the assay of creatine kinase(CK) isoenzymes by continuous monitoring of the ATP formationin the CK reaction by a purified firefly luciferase reagenthas been developed. The sensitivity of the firefly assay ofATP makes it possible to assay CK-B subunit activity (CK-B)in serum down to 1 U/l. In healthy individuals CK-B varied between 2 and 12, mean 3U/l. A wide range of CK-B activity was observed after acutemyocardial infarction (AMI), intramuscular injection and surgerywith overlapping between these different categories. Thereforethe maximal change in CK-B activity (CK-B) was studied in 98patients admitted to a coronary care unit. In all 57 patientswithout a subsequent diagnosis of AMI according to conventionalcriteria CK-B was < 5 U/l. In all 41 patients with AMI CK-Bwas 5 U/l. In all healthy individuals CK-B was < 2 U/l.CK-B 5 U/l was found after i.m. injection and different kindsof surgery in three out of 60 patients. Thus, the present method for determination of CK activity hasbeen shown to possess high precision in low activities, to beas rapid as conventional methods and to be simple enough tobe used in a routine laboratory. With these properties the methodshould be suited for early diagnosis and early exclusion ofeven very small AMIs.     

4.

Esophageal varices in hepatic cirrhosis: an endoscopic study     

FRIEDBERG SA  BENNETT HD  SINGH H  LINDBERG J 《The Annals of otology, rhinology, and laryngology》1955,64(2):599-607

     

5.

ASYMPTOMATIC BACTERIURIA IN SCHOOLGIRLS VI. The Correlation between Urinary and Faecal Escherichia coli. Relation to the Duration of the Bacteriuria and the Sampling Technique     

G. LIDIN-JANSON  U. LINDBERG 《Acta paediatrica (Oslo, Norway : 1992)》1977,66(3):349-354

Abstract. The occurrence of the urinary strain in the anus, rectum and faeces was investigated in 27 girls with asymptomatic bacteriuria (ABU). In patients with bacteriuria of relatively short duration 46% of the faecal isolates were of the urinary strain as compared to only 18% in patients with bacteriuria of relatively long duration. In general the correlation between the urinary and faecal flora is striking at the time of establishment of ABU but diminishes with time. The diminished correlation may be due to two factors: firstly, the composition of the faecal flora changes with time. Secondly, the correlation may be obscured by complex changes in the properties of bacterial strains established in the urinary tract. Contamination by the infected urine did not seem to be a serious problem when the rectal mucosa was swabbed proximal to the anal canal.     

6.

MILD MENTAL RETARDATION IN SWEDISH SCHOOL CHILDREN   总被引：6，自引：0，他引：6  

B. HAGBERG  G. HAGBERG  A. LEWERTH  U. LINDBERG 《Acta paediatrica (Oslo, Norway : 1992)》1981,70(4):445-452

ABSTRACT. Hagberg, B., Hagberg, G., Lewerth, A. and Lindberg. U. (Department of Paediatrics II, Östra sjukhuset, Gothenburg, Sweden). Mild mental retardation in Swedish School children. I. Prevalence. Acta Paediatr Scand, 70:441, 1981.In an unselected series of Swedish school children born 1966-70, the prevalence of mild mental retardation, defined as an IQ of 50–70, was determined. A prevalence of 0.4 % was revealed. The findings in this study, supported by recent IQ analyses in other Scandinavian countries, indicate that a true prevalence for the IQ range 50–70 was ascertained. The high average social standard and early social stimulation are put forth as a likely explanation for the low prevalence of mild mental retardation in Swedish preschool and school children.     

7.

HOW TO APPROACH THE CHILD SUSPECTED OF MALABSORPTION Experience from a Prospective Investigation of Suspected Malabsorption in Children 1968–1976 in Malmö     

N. O. BERG  S. BORULF  I. JAKOBSSON  T. LINDBERG 《Acta paediatrica (Oslo, Norway : 1992)》1978,67(4):403-411

ABSTRACT. 180 children (mean age 20 months) suspected of malabsorption because of failure to thrive, abnormal stools more than 3 weeks, vomiting, an/or abdominal distension were investigated with peroral small intestinal biopsy at duodeno-jejunal flexure (172 children) and/or duodenal intubation for analysis of trypsin and amylase activity in duodenal juice before and after a test meal of water (76 children). Results of xylose tolerance test, lactose tolerance test, faecal fat, B-folate, S-iron, and S-albumin were related to morphology of mucosa. A normal finding of one of these tests means in 15–26% a normal mucosa (diagnostic sensitivity). An abnormal finding means in 40–85% a severely damaged mucosa and in 85–100% a slightly, moderately, or severely damaged mucosa (diagnostic specificity). Combinations of these tests increase the diagnostic sensitivity 10–15%. Faecal chymotrypsin seems to be a reliable screening test for exocrine pancreatic function. Border values or low values indicate a direct evaluation of exocrine pancreatic function. The simple test meal (water) method with determination of trypsin in duodenal juice gives, from a practical point of view, good information of the exocrine pancreatic function.
The following plan of investigation is proposed: Step 1. careful clinical history and examination; Step 2. analysis of faeces for Giardia lamblia, entero-pathogenic microorganisms, and chymotrypsin, sweat test; Step 3. peroral small intestinal biopsy and/or duodenal juice analysis, and finally—if steps 2 and 3 give normal results; Step 4. re-evaluation of dietary history and tests to detect any food intolerance (e.g. carbohydrate).     

8.

LEVEL DIAGNOSIS OF SYMPTOMATIC URINARY TRACT INFECTIONS IN CHILDHOOD   总被引：12，自引：0，他引：12  

U. JODAL  U. LINDBERG  K. LINCOLN 《Acta paediatrica (Oslo, Norway : 1992)》1975,64(2):201-208

ABSTRACT: Jodal, U., Lindberg, U. and Lincoln, K. (Department of Paediatrics and Institute of Medical Microbiology, University of Göteborg, Göteborg, Sweden). Level diagnosis of symptomatic urinary tract infections in childhood. Acta Paediatr Scand, 64:201, 1975.–As no method for localization of urinary tract infection has been shown to be absolutely reliable, six procedures have been carried out simultaneously in 25 girls with acute symptomatic infections and the reliability of each method assessed. While clinical diagnosis of pyelonephritis or cystitis correlated well with the overall results of the battery of tests, the reliability of individual tests varied. Highest reliability was obtained with CRP determinations followed by antibody titration, sedimentation rate, and renal concentrating capacity. In the bladder washout test only 8 of the 14 patients with pyelonephritis had findings clearly indicating high infection. Intermittent or inadequate discharge of bacteria from the renal parenchyma is suggested as the major source for this inaccuracy. In fact, half of the 42 final washout specimens from girls with acute pyelonephritis contained less than 1 000 bacteria per ml, indicating that low numbers of organisms in ureteric urine is common in childhood pyelonephritis.     

9.

The indications for splenectomy and the care of the splenectomized patient     

LINDBERG RF 《The Journal of the American Osteopathic Association》1949,48(6):319-322

     

10.

Studien Über die Wirkung des Atropins beim gesunden und kranken Säugling.     

GUSTAF LINDBERG 《Acta paediatrica (Oslo, Norway : 1992)》1925,4(3-4):309-355

     

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Detection of acute myocardial infarction by a new, sensitive and rabid method for determination of creatine kinase B-subunit activity

An immunoinhibition method for the assay of creatine kinase(CK) isoenzymes by continuous monitoring of the ATP formationin the CK reaction by a purified firefly luciferase reagenthas been developed. The sensitivity of the firefly assay ofATP makes it possible to assay CK-B subunit activity (CK-B)in serum down to 1 U/l. In healthy individuals CK-B varied between 2 and 12, mean 3U/l. A wide range of CK-B activity was observed after acutemyocardial infarction (AMI), intramuscular injection and surgerywith overlapping between these different categories. Thereforethe maximal change in CK-B activity (CK-B) was studied in 98patients admitted to a coronary care unit. In all 57 patientswithout a subsequent diagnosis of AMI according to conventionalcriteria CK-B was < 5 U/l. In all 41 patients with AMI CK-Bwas 5 U/l. In all healthy individuals CK-B was < 2 U/l.CK-B 5 U/l was found after i.m. injection and different kindsof surgery in three out of 60 patients. Thus, the present method for determination of CK activity hasbeen shown to possess high precision in low activities, to beas rapid as conventional methods and to be simple enough tobe used in a routine laboratory. With these properties the methodshould be suited for early diagnosis and early exclusion ofeven very small AMIs.     

ASYMPTOMATIC BACTERIURIA IN SCHOOLGIRLS VI. The Correlation between Urinary and Faecal Escherichia coli. Relation to the Duration of the Bacteriuria and the Sampling Technique

Abstract. The occurrence of the urinary strain in the anus, rectum and faeces was investigated in 27 girls with asymptomatic bacteriuria (ABU). In patients with bacteriuria of relatively short duration 46% of the faecal isolates were of the urinary strain as compared to only 18% in patients with bacteriuria of relatively long duration. In general the correlation between the urinary and faecal flora is striking at the time of establishment of ABU but diminishes with time. The diminished correlation may be due to two factors: firstly, the composition of the faecal flora changes with time. Secondly, the correlation may be obscured by complex changes in the properties of bacterial strains established in the urinary tract. Contamination by the infected urine did not seem to be a serious problem when the rectal mucosa was swabbed proximal to the anal canal.     

MILD MENTAL RETARDATION IN SWEDISH SCHOOL CHILDREN

ABSTRACT. Hagberg, B., Hagberg, G., Lewerth, A. and Lindberg. U. (Department of Paediatrics II, Östra sjukhuset, Gothenburg, Sweden). Mild mental retardation in Swedish School children. I. Prevalence. Acta Paediatr Scand, 70:441, 1981.In an unselected series of Swedish school children born 1966-70, the prevalence of mild mental retardation, defined as an IQ of 50–70, was determined. A prevalence of 0.4 % was revealed. The findings in this study, supported by recent IQ analyses in other Scandinavian countries, indicate that a true prevalence for the IQ range 50–70 was ascertained. The high average social standard and early social stimulation are put forth as a likely explanation for the low prevalence of mild mental retardation in Swedish preschool and school children.     

HOW TO APPROACH THE CHILD SUSPECTED OF MALABSORPTION Experience from a Prospective Investigation of Suspected Malabsorption in Children 1968–1976 in Malmö

ABSTRACT. 180 children (mean age 20 months) suspected of malabsorption because of failure to thrive, abnormal stools more than 3 weeks, vomiting, an/or abdominal distension were investigated with peroral small intestinal biopsy at duodeno-jejunal flexure (172 children) and/or duodenal intubation for analysis of trypsin and amylase activity in duodenal juice before and after a test meal of water (76 children). Results of xylose tolerance test, lactose tolerance test, faecal fat, B-folate, S-iron, and S-albumin were related to morphology of mucosa. A normal finding of one of these tests means in 15–26% a normal mucosa (diagnostic sensitivity). An abnormal finding means in 40–85% a severely damaged mucosa and in 85–100% a slightly, moderately, or severely damaged mucosa (diagnostic specificity). Combinations of these tests increase the diagnostic sensitivity 10–15%. Faecal chymotrypsin seems to be a reliable screening test for exocrine pancreatic function. Border values or low values indicate a direct evaluation of exocrine pancreatic function. The simple test meal (water) method with determination of trypsin in duodenal juice gives, from a practical point of view, good information of the exocrine pancreatic function.
The following plan of investigation is proposed: Step 1. careful clinical history and examination; Step 2. analysis of faeces for Giardia lamblia, entero-pathogenic microorganisms, and chymotrypsin, sweat test; Step 3. peroral small intestinal biopsy and/or duodenal juice analysis, and finally—if steps 2 and 3 give normal results; Step 4. re-evaluation of dietary history and tests to detect any food intolerance (e.g. carbohydrate).     

LEVEL DIAGNOSIS OF SYMPTOMATIC URINARY TRACT INFECTIONS IN CHILDHOOD

ABSTRACT: Jodal, U., Lindberg, U. and Lincoln, K. (Department of Paediatrics and Institute of Medical Microbiology, University of Göteborg, Göteborg, Sweden). Level diagnosis of symptomatic urinary tract infections in childhood. Acta Paediatr Scand, 64:201, 1975.–As no method for localization of urinary tract infection has been shown to be absolutely reliable, six procedures have been carried out simultaneously in 25 girls with acute symptomatic infections and the reliability of each method assessed. While clinical diagnosis of pyelonephritis or cystitis correlated well with the overall results of the battery of tests, the reliability of individual tests varied. Highest reliability was obtained with CRP determinations followed by antibody titration, sedimentation rate, and renal concentrating capacity. In the bladder washout test only 8 of the 14 patients with pyelonephritis had findings clearly indicating high infection. Intermittent or inadequate discharge of bacteria from the renal parenchyma is suggested as the major source for this inaccuracy. In fact, half of the 42 final washout specimens from girls with acute pyelonephritis contained less than 1 000 bacteria per ml, indicating that low numbers of organisms in ureteric urine is common in childhood pyelonephritis.