Patterns of hand preference and unintentional injuries among Indian attempted hand switchers and hand non-switchers

This study examines the patterns of hand preference and unintentional injuries of attempted hand switchers and hand non-switchers. Data were collected from 3698 participants in Kharagpur, India, on measures of hand preference, hand switching, and unintentional injuries. The direction of left- or right-handedness was on the basis of hand used for the item “writing on paper” and the degree of handedness was based on the average score of remaining items in the handedness inventory. Results reveal that, among attempted hand-switchers, learned right-handers were not right-sided in hand continuum as the natural right-handers, but left-handers were left-sided as natural left-handers. With increasing age the learned right-handers become less right-sided and natural right-handers become more right-sided. Females (males) are found to be more right-handed than males (females) among learned right-handers (natural right-handers). On the direction of handedness, the learned right-handers have more than twice the risk of unintentional injuries than the natural right- and left-handers. On degree of handedness, the use of inconsistent left and both hands among natural left-handers, the use of inconsistent right and both hands among natural right-handers, and the use of weak right hand among learned right-handers increase their vulnerability to unintentional injuries. Any deviation from the genetic make-up in hand use elevates the risk of unintentional injuries, suggesting that one should not change the biological hand.     

Supercyclone in Orissa: an assessment of psychological status of survivors

The study assessed the impact of the Orissa supercyclone on survivors' locus of control, anxiety, depression, and posttraumatic stress. The study was conducted in structured interview sessions 3 months after the supercyclone. The affected people (n = 65) who were close to the epicenter of supercyclone and lost their family members, relatives, and property, experienced more anxiety, depression, and posttraumatic stress than the unaffected (n = 65) who were away from the epicenter of supercyclone and had not experienced any loss. Effects of exposure remained significant with the effects of sex and neuroticism controlled. External support reduced anxiety and depression, and the amount of loss experienced by the survivors significantly increased external locus of control and anxiety.     

Bereavement,Postdisaster Trauma,and Behavioral Changes in Tsunami Survivors

This study examined whether the death of family members intensifies the survivors' posttraumatic stress and behavioral changes. Data were collected by interviewing 416 adult survivors from nine habitations of the Nagapattinam district in the state of Tamil Nadu in India 14 months after the 2004 tsunami. Compared to those nonbereaved, bereaved survivors reported more posttraumatic stress disorder, depression, anxiety, negative affect, deteriorated mental health, adverse physical health symptoms, alcohol consumption, family conflicts, and fear. When a tsunami trauma includes death of a loved one, psychological, physical, and behavioral ramifications are especially severe.     

Plausible role of bacterial toxin–antitoxin system in persister cell formation and elimination

Although, a large proportion of pathogenic bacteria gets eliminated from hosts after antibiotic treatment, a fraction of population confronts against such effects and undergoes growth arrest to form persisters. Persistence in bacteria is a dormant physiological state where cells escape the effects of antimicrobials as well as other host immune defences without any genetic mutations. The state of dormancy is achieved through various complex phenomena and it is known that a gene pair named as toxin–antitoxin (TA) acts as a key player of persister cell formation where the toxin is activated either stochastically or after an environmental insult, thereby silencing the physiological processes. However, the controversial role of TA modules in persister cell formation has also been documented with reasonable clarity. Persisters may revert back from state of quiescence and regrow when conditions become favourable for their propagation. Therefore, the elimination of dormant bacteria is crucial, and currently, research interest is highly focussed on developing several antipersister strategies that may kill persister bacteria by targeting different molecules . It is worth examining these targets to develop appropriate therapeutic interventions against bacterial infections and it is believed that earmarking TA system can be a novel approach for resuscitation of persisters. In this review, we discussed the role of TA modules in mediating persistence with highlighting on the debatable issues regarding contribution of these modules in dormant bacteria formation. Furthermore, we discussed if these modules in bacteria can be targeted for successful elimination of dormant persister cells.     

Hematopoietic stem cell transplantation from unrelated donors in children with DOCK8 deficiency

DIDS is a unique form of combined immune deficiency characterized by an unusual susceptibility to cutaneous viral infections, severe allergies with eosinophilia and elevated immunoglobulin E titers, autoimmunity, and cancer. HSCT is considered the standard of care for this deadly disease. We have retrospectively analyzed the outcome of allogeneic HSCT from unrelated donors in patients with DIDS. Data from four patients, with five transplants, are presented. All patients received transplants from unrelated donors' BM, except for one patient who received a cord blood transplant. The conditioning regimens were based on myeloablative protocols for BM derived transplants; a NM regimen was pursued for the patient who received a cord blood transplant, which resulted in graft rejection. Although recurrent pneumonia and skin infections resolved immediately after transplantation, all patients subsequently developed human herpesvirus infection, including cutaneous herpetic lesions, cytomegalovirus reactivation, and zona zoster, which could be attributed to the use of ATG. Despite the presence of serious morbidities prior to transplantation, all patients recovered successfully. DIDS can be successfully treated with allogeneic HSCT from unrelated donors following a myeloablative conditioning regimen, with a reasonable safety profile.     

Virulence of broad- and narrow-host-range Salmonella enterica serovars in the streptomycin-pretreated mouse model

Salmonella enterica subspecies I serovars are common bacterial pathogens causing diseases ranging from enterocolitis to systemic infections. Some serovars are adapted to specific hosts, whereas others have a broad host range. The molecular mechanisms defining the virulence characteristics and the host range of a given S. enterica serovar are unknown. Streptomycin pretreated mice provide a surrogate host model for studying molecular aspects of the intestinal inflammation (colitis) caused by serovar Typhimurium (S. Hapfelmeier and W. D. Hardt, Trends Microbiol. 13:497-503, 2005). Here, we studied whether this animal model is also useful for studying other S. enterica subspecies I serovars. All three tested strains of the broad-host-range serovar Enteritidis (125109, 5496/98, and 832/99) caused pronounced colitis and systemic infection in streptomycin pretreated mice. Different levels of virulence were observed among three tested strains of the host-adapted serovar Dublin (SARB13, SD2229, and SD3246). Several strains of host restricted serovars were also studied. Two serovar Pullorum strains (X3543 and 449/87) caused intermediate levels of colitis. No intestinal inflammation was observed upon infection with three different serovar Paratyphi A strains (SARB42, 2804/96, and 5314/98) and one serovar Gallinarum strain (X3796). A second serovar Gallinarum strain (287/91) was highly virulent and caused severe colitis. This strain awaits future analysis. In conclusion, the streptomycin pretreated mouse model can provide an additional tool to study virulence factors (i.e., those involved in enteropathogenesis) of various S. enterica subspecies I serovars. Five of these strains (125109, 2229, 287/91, 449/87, and SARB42) are subject of Salmonella genome sequencing projects. The streptomycin pretreated mouse model may be useful for testing hypotheses derived from this genomic data.