全文获取类型
收费全文 | 263篇 |
免费 | 11篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 82篇 |
妇产科学 | 24篇 |
基础医学 | 30篇 |
口腔科学 | 2篇 |
临床医学 | 9篇 |
内科学 | 34篇 |
皮肤病学 | 5篇 |
神经病学 | 14篇 |
特种医学 | 4篇 |
外科学 | 14篇 |
综合类 | 9篇 |
预防医学 | 9篇 |
眼科学 | 3篇 |
药学 | 22篇 |
中国医学 | 1篇 |
肿瘤学 | 14篇 |
出版年
2022年 | 2篇 |
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 5篇 |
2017年 | 1篇 |
2016年 | 5篇 |
2015年 | 7篇 |
2014年 | 11篇 |
2013年 | 12篇 |
2012年 | 28篇 |
2011年 | 34篇 |
2010年 | 10篇 |
2009年 | 4篇 |
2008年 | 10篇 |
2007年 | 15篇 |
2006年 | 14篇 |
2005年 | 10篇 |
2004年 | 12篇 |
2003年 | 12篇 |
2002年 | 14篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 7篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 8篇 |
1983年 | 4篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1970年 | 2篇 |
排序方式: 共有276条查询结果,搜索用时 9 毫秒
1.
Dunn GP Bruce AT Sheehan KC Shankaran V Uppaluri R Bui JD Diamond MS Koebel CM Arthur C White JM Schreiber RD 《Nature immunology》2005,6(7):722-729
'Cancer immunoediting' is a process wherein the immune system protects hosts against tumor development and facilitates outgrowth of tumors with reduced immunogenicity. Although interferon-gamma (IFN-gamma) is known to be involved in this process, the involvement of type I interferons (IFN-alpha/beta) has not been elucidated. We now show that, like IFN-gamma, endogenously produced IFN-alpha/beta was required for the prevention of the growth of primary carcinogen-induced and transplantable tumors. Although tumor cells are important IFN-gamma targets, they are not functionally relevant sites of the actions of the type I interferons. Instead, host hematopoietic cells are critical IFN-alpha/beta targets during development of protective antitumor responses. Therefore, type I interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-gamma. 相似文献
2.
Shankaran S Laptook AR Ehrenkranz RA Tyson JE McDonald SA Donovan EF Fanaroff AA Poole WK Wright LL Higgins RD Finer NN Carlo WA Duara S Oh W Cotten CM Stevenson DK Stoll BJ Lemons JA Guillet R Jobe AH;National Institute of Child Health Human Development Neonatal Research Network 《The New England journal of medicine》2005,353(15):1574-1584
3.
Eradication of established tumors by CD8+ T cell adoptive immunotherapy 总被引:14,自引:0,他引:14
Hanson HL Donermeyer DL Ikeda H White JM Shankaran V Old LJ Shiku H Schreiber RD Allen PM 《Immunity》2000,13(2):265-276
We generated the DUC18 T cell receptor transgenic mouse expressing an H-2Kd -restricted transgenic T cell receptor specific for the syngeneic CMS5 fibrosarcoma rejection antigen mutated ERK2(136-144). DUC18 mice were capable of specifically eliminating lethal CMS5 tumor challenges, and transfer of DUC18 splenocytes to naive nontransgenic recipients conferred protection from subsequent and established CMS5 tumor burdens. Eradication of established tumor burdens by adoptive transfer of DUC18 splenocytes was dose and time dependent. Transferred tumor-specific T cells remained functional in vivo and capable of rejecting small tumors even in the presence of large, established tumor burdens. These findings highlight the kinetic battle between tumor growth and the production of a tumor-specific response and have critical implications for effective adoptive immunotherapy. 相似文献
4.
One thousand one hundred and seventy cerebro spinal fluid (CSF) samples from clinically diagnosed meningitis patients were subjected to macroscopic and microscopic examination. CSF samples were also cultured. Five percent CSF samples were positive for bacterial (4.3%) and fungal (0.7%) organisms. Gram positivity was observed in 6.4% samples. The percentage of bacterial isolates was highest in newborn and infants (6.1%) and (4.3%) in patients of 1-12 years age group. Cryptococcus species were isolated from 8 adult patients. Among Gram positive bacterial isolates, coagulase negative Staphylococci was highest (8%), followed by Pneumococci (6%) and B-haemolytic Streptococci (2%). Among Gram negative bacilli, Pseudomonas aeruginosa was predominant (42%) followed by Klebsiella species (20%) though Klebsiella was predominant in newborns and infants. 相似文献
5.
The mechanism of 3,4-methylenedioxymethamphetamine (MDMA)-induced depletion of brain serotonin (5-hydroxytryptamine, 5-HT) has been proposed to involve the generation of reactive oxygen species. In the present study, quantification of the extracellular concentration of 2,3-dihydroxybenzoic acid (2,3-DHBA) from salicylic acid was used as an index of hydroxyl radical generation. Although both MDMA and D-amphetamine markedly increased the extracellular concentration of dopamine in the striatum, only MDMA increased the extracellular concentration of 2,3-DHBA. Treatment with fluoxetine either 1 h prior to or 4 h following the administration of MDMA reduced the MDMA-induced formation of 2,3-DHBA and also attenuated the MDMA-induced depletion of 5-HT in the striatum. These results are supportive of the view that the MDMA-induced generation of hydroxyl radicals and, ultimately, the long-term depletion of 5-HT, is dependent, in part, on the activation of the 5-HT transporter. 相似文献
6.
7.
8.
9.
Over the last decade, the role of dendritic cells (DCs) in the immunopathogenesis of systemic lupus erythematosus (SLE) has
become apparent. As unique mediators of both tolerance and immunity, aberrant myeloid and plasmacytoid DC function can promote
autoimmune responses via a number of mechanisms and proinflammatory pathways. This review provides an overview of DC function,
the potential role of DCs in promoting autoimmune responses in SLE, and how other abnormalities in lupus can lead to an enhanced
engagement of DCs in immune responses. How medications used to treat SLE and other autoimmune conditions may exert effects
on DCs is also explored. 相似文献
10.