全文获取类型
收费全文 | 502篇 |
免费 | 41篇 |
国内免费 | 23篇 |
专业分类
儿科学 | 23篇 |
妇产科学 | 6篇 |
基础医学 | 64篇 |
口腔科学 | 9篇 |
临床医学 | 70篇 |
内科学 | 129篇 |
皮肤病学 | 30篇 |
神经病学 | 29篇 |
特种医学 | 79篇 |
外科学 | 21篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 34篇 |
药学 | 31篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 3篇 |
2019年 | 7篇 |
2018年 | 9篇 |
2017年 | 7篇 |
2016年 | 5篇 |
2015年 | 13篇 |
2014年 | 7篇 |
2013年 | 15篇 |
2012年 | 20篇 |
2011年 | 15篇 |
2010年 | 19篇 |
2009年 | 19篇 |
2008年 | 17篇 |
2007年 | 24篇 |
2006年 | 16篇 |
2005年 | 18篇 |
2004年 | 12篇 |
2003年 | 14篇 |
2002年 | 16篇 |
2001年 | 14篇 |
2000年 | 11篇 |
1999年 | 10篇 |
1998年 | 22篇 |
1997年 | 15篇 |
1996年 | 29篇 |
1995年 | 8篇 |
1994年 | 19篇 |
1993年 | 10篇 |
1992年 | 6篇 |
1991年 | 9篇 |
1990年 | 11篇 |
1989年 | 9篇 |
1988年 | 16篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 15篇 |
1984年 | 6篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1977年 | 7篇 |
1976年 | 8篇 |
1975年 | 4篇 |
1973年 | 4篇 |
1971年 | 2篇 |
排序方式: 共有566条查询结果,搜索用时 29 毫秒
1.
SB Miranda† O Lupi‡ E Lucas† 《Journal of the European Academy of Dermatology and Venereology》2004,18(5):622-625
Pityriasis rosea (PR) is a relatively common disease although its aetiology has not yet been identified. It occurs worldwide and there is no racial susceptibility factor. It usually affects teenagers and young adults between 10 and 35 years of age. Typical PR is much easier to diagnose than the rare atypical forms. We report a rare case of vesicular PR in a black woman who had vesicular lesions limited to her palms and soles in addition to regular typical lesions. We devised an efficient oral erythromycin treatment for this patient. 相似文献
2.
3.
4.
5.
进一步研究了抗三尖杉酯碱的HL-60细胞(HR20)抗细胞凋亡的机制及该抗性和抗药性的关系。结果表明,环孢菌素A(CsA)20,10μg·ml ̄(-1)诱导HL-60细胞发生凋亡,而阻断HR20细胞于G_1期,就不能诱导细胞发生凋亡。低浓度的CsA明显增加柔红霉素在HR20细胞内的积聚,其逆转抗药性作用与阻断细胞周期运行无关。CsA10μg·ml ̄(-1)处理HR20细胞,可引起50kDa的蛋白质高度磷酸化。结果提示:环孢菌素A阻断抗三尖杉酯碱的HL-60细胞于G_1期,而诱导敏感的HL-60细胞发生凋亡,其阻断作用与抗药性无关 相似文献
6.
Robert A. Kinsman Enrique Fernandez Marsha Schocket Jerald F. Dirks Nicholas A. Covino 《Journal of behavioral medicine》1983,6(4):339-357
Subjective symptoms and experiences were explored within a group of 146 severe, chronic bronchitis and emphysema patients. Eighty-nine symptoms and experiences, derived from initial interviews with 29 patients, were rated according to the frequency of occurrence during breathing difficulties. Key cluster analyses were used to derive a Bronchitis-Emphysema Symptom Checklist (BESC) measuring 11 symptom categories: Helplessness-Hopelessness, Decathexis, Fatigue, Poor Memory, Peripheral-Sensory Complaints, Dyspnea, Congestion, Sleep Difficulties, Irritability, Anxiety, and Alienation. The BESC symptom categories are highly reliable and the relationships among categories are stable across two subgroups of patients. The BESC provides one way to describe how patients cope with and experience chronic bronchitis and emphysema. 相似文献
7.
Medical outcome in asthmatic patients: effects of airways hyperreactivity and symptom-focused anxiety. 总被引:3,自引:0,他引:3
H Staudenmayer R A Kinsman J F Dirks S L Spector C Wangaard 《Psychosomatic medicine》1979,41(2):109-118
Hypotheses about medical outcome in asthma, indexed by rates of rehospitalization within 6 months after discharge from long-term intensive care, were evaluated. Predictions for rehospitalization were based on the levels of airways hyperreactivity, indexed by inhalation challenges with histamine or methacholine, and levels of anxiety focused upon and concurrent with periods of asthmatic distress, indexed by Panic-Fear symptomatology. Results indicated that, although some prediction could be made on the basis of levels of anxiety and airways hyperreactivity alone, the best predictions resulted from the combined effects of these factors. Almost half of the patients who had highly hyperreactive airways and a tendency to disregard symptoms of breathing difficulty were rehospitalized. By comparison, none of the patients who had less hyperreactive airways and a tendency to be vigilant about their symptoms were rehospitalized. The hypotheses and results are discussed with respect to symptom-focused and general, illness-dependent types of anxiety which have different effects upon medical outcome in chronic asthma. The results have implications for the application of anxiety-reducing forms of intervention in asthma. 相似文献
8.
Robert A. Kinsman Katy O'Banion Sharon Robinson Herman Staudenmayer 《Psychophysiology》1975,12(1):30-35
During training to relax the frontalis muscle, continuous biofeedback (BF) was compared to discrete verbal feedback (VF) delivered immediately after each trial. Both feedback modalities were based on frontalis electromyographic (EMG) activity. Training consisted of 3 consecutive daily session-each comprised of 3 baseline (nonfeedback) trials followed by 10 training trials of 128 see. The presence or absence of the two informationally positive feedback modalities were combined factorially to define four training conditions: BF + VF, NO BF + VF, BF + NO VF, and NO BF + NO VF. Results indicated that while VF alone facilitated muscle relaxation, BF was clearly prepotent ill effecting consistent decreases in EMG activity both across trials and days of training. Additionally, the facilitating effect of BF transferred to nonfeedback trials while VF did not affect performance on nonfeedback trials. Finally, accuracy of self-evaluations of performance on a trial by trial basis was markedly improved by BF, while VF improved accuracy only for trials having a very large absolute difference between levels of EMG activity. Ss receiving no feedback neither reduced muscle tension during training not were able to evaluate their performance accurately even when large absolute differences occurred between trials in frontalis EMG activity. 相似文献
9.
Needle biopsy of renal allografts: comparison of two techniques 总被引:2,自引:0,他引:2
Bogan ML; Kopecky KK; Kraft JL; Holladay AO; Filo RS; Leapman SB; Thomalla JV 《Radiology》1990,174(1):273-275
Two techniques for renal allograft biopsy were retrospectively evaluated to compare relative safety and efficacy. After ultrasound (US) localization of the kidney and biopsy with a hand-held 14-gauge cutting needle, an adequate specimen was obtained in 74 of 77 cases (96%). Major complications occurred in six of these 77 cases (8%). One hundred four biopsies were performed by using a smaller 18-gauge cutting needle with a spring-loaded biopsy "gun" and real-time US guidance. With this newer technique, specimens adequate for diagnosis were obtained in 99 biopsies (95%). There was a single major complication with this technique (1%). The 18-gauge needle with real-time US guidance yields comparably adequate specimens with a lower frequency of complications. 相似文献
10.
Docimo SG Chow NH Steiner G Silver RI Rodriguez R Kinsman S Sidransky D Schoenberg M 《Urology》1999,54(3):561
Augmentation cystoplasty is associated with an increased risk of bladder cancer development between 10 and 20 years after augmentation. Using microsatellite analysis, we analyzed urine obtained before surgical resection of the malignant lesion from a patient who developed invasive adenocarcinoma after augmentation cystoplasty. Loss of heterozygosity was identified in both urine and tumor samples from this patient. This observation suggests that microsatellite urine analysis may be useful as a monitoring tool for patients after augmentation cystoplasty. 相似文献