全文获取类型
收费全文 | 2159篇 |
免费 | 202篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 102篇 |
妇产科学 | 49篇 |
基础医学 | 253篇 |
口腔科学 | 152篇 |
临床医学 | 174篇 |
内科学 | 307篇 |
皮肤病学 | 47篇 |
神经病学 | 213篇 |
特种医学 | 145篇 |
外科学 | 246篇 |
综合类 | 145篇 |
一般理论 | 1篇 |
预防医学 | 215篇 |
眼科学 | 38篇 |
药学 | 118篇 |
中国医学 | 42篇 |
肿瘤学 | 122篇 |
出版年
2023年 | 13篇 |
2022年 | 22篇 |
2021年 | 43篇 |
2020年 | 30篇 |
2019年 | 33篇 |
2018年 | 40篇 |
2017年 | 39篇 |
2016年 | 41篇 |
2015年 | 63篇 |
2014年 | 72篇 |
2013年 | 78篇 |
2012年 | 102篇 |
2011年 | 126篇 |
2010年 | 101篇 |
2009年 | 102篇 |
2008年 | 87篇 |
2007年 | 95篇 |
2006年 | 99篇 |
2005年 | 78篇 |
2004年 | 59篇 |
2003年 | 64篇 |
2002年 | 52篇 |
2001年 | 40篇 |
2000年 | 49篇 |
1999年 | 51篇 |
1998年 | 63篇 |
1997年 | 78篇 |
1996年 | 67篇 |
1995年 | 49篇 |
1994年 | 40篇 |
1993年 | 41篇 |
1992年 | 27篇 |
1991年 | 19篇 |
1990年 | 34篇 |
1989年 | 53篇 |
1988年 | 31篇 |
1987年 | 27篇 |
1986年 | 28篇 |
1985年 | 19篇 |
1984年 | 16篇 |
1982年 | 17篇 |
1981年 | 15篇 |
1980年 | 18篇 |
1979年 | 11篇 |
1977年 | 17篇 |
1976年 | 20篇 |
1974年 | 15篇 |
1973年 | 12篇 |
1972年 | 10篇 |
1971年 | 11篇 |
排序方式: 共有2378条查询结果,搜索用时 15 毫秒
1.
Workplace status and risk of hypertension among hourly and salaried aluminum manufacturing employees
Jane Ellen Clougherty Ellen A. Eisen Martin D. Slade Ichiro Kawachi Mark R. Cullen 《Social science & medicine (1982)》2009
An inverse relationship between workplace status and morbidity is well established; higher job status has been associated with reduced risks of heart disease, hypertension, and injury. Most research on job status, however, has focused on salaried populations, and it remains unclear whether job status operates similarly among hourly workers. Our objectives were to examine whether hourly status itself influences risk of hypertension after adjustment for socioeconomic confounders, and to explore the role of fine-scale job grade on hypertension incidence within hourly and salaried groups. We examined data for 14,999 aluminum manufacturing employees in 11 plants across the U.S., using logistic regression with adjustment for age, sex, race/ethnicity and other individual characteristics. Propensity score restriction was used to identify comparable groups of hourly and salaried employees, reducing confounding by sociodemographic characteristics. Job grade (coded 1 through 30, within hourly and salaried groups) was examined as a more refined measure of job status. Hourly status was associated with an increased risk of hypertension, after propensity restriction and adjustment for confounders. The observed effect of hourly status was stronger among women, although the propensity-restricted cohort was disproportionately male (96%). Among salaried workers, higher job grade was not consistently associated with decreased risk; among hourly employees, however, there was a significant trend, with higher job grades more protective against hypertension. Increasing the stringency of hypertension case criteria also increased the risk of severe or persistent hypertension for hourly employees. 相似文献
2.
3.
Suppurative corneal ulceration in Bangladesh 总被引:8,自引:0,他引:8
AAS Dunlop MB BS ED Wright MRCPath † SA Howlader‡ I Nazrul‡ R Husain‡ K McClellan FRACO § FA Billson FRACO § 《Clinical & experimental ophthalmology》1994,22(2):105-110
Suppurative keratitis is an important preventable cause of blindness, particularly in the developing world. This study analyses 142 cases of suppurative keratitis referred to Chittagong Eye Infirmary, Bangladesh. Some 53.5% of cases were bacterial and 35.9% were fungal. The five most common pathogens were: Pseudomonas sp. 24%, Streptococcus pneumoniae 17%, Aspergillus sp. 13%, Fusarium sp. 7% and Curvularia sp. 6%. Gram stain and culture results were consistent in 62.6% of cases. Previous antibiotic treatment was a significant factor for failure of culture isolation and less so for Gram stain failure. On Gram stain, 55.9% of pseudomonal cases were missed, but only 2% of fungal cases were missed. Over all, Gram stain had a sensitivity of 62% and positive predictive value of 84% for bacterial cases, and 98% and 94% for fungal cases, respectively. Fungal ulcers were typically filamentous, but an antecedent history of trauma was not common. The most frequent injury was due to rice grains, but the inoculum appeared to be introduced during eye washing with contaminated water. Pseudomonal ulcers occurred most frequently in the monsoon season, and Fusarium cases were seen only in the hot, dry season. 相似文献
4.
5.
Prednisone induced reductions in the circulating human T cell population follow a characteristic time curve which persists even after a single daily dose of oral prednisone has been administered many times. If prednisone doses are administered every 6 h, so that a dose occurs near the point of maximum response from a previous dose (4-6 h), the reduction in size of the circulating T cell population will persist so long as administration of prednisone continues. A chronically depressed ratio of OKT4+ to OKT8+ cells is observed in most patients when as little as 2.5 mg of prednisone is administered every 6 h. 相似文献
6.
7.
8.
9.
Nonheme iron in sickle erythrocyte membranes: association with phospholipids and potential role in lipid peroxidation 总被引:5,自引:0,他引:5
Previous studies documented the abnormal association of heme and heme proteins with the sickle RBC membrane. We have now examined RBC ghosts and inside-out membranes (IOM) for the presence of nonheme iron as detected by its formation of a colored complex with ferrozine. Sickle ghosts have 33.8 +/- 18.2 nmol nonheme iron/mg membrane protein, and sickle IOM have 4.3 +/- 3.0 nmol/mg. In contrast, normal RBC ghosts and IOM have no detectable nonheme iron. The combination of heme and nonheme iron in sickle IOM averages nine times the amount of membrane- associated iron in normal IOM. Kinetics of the ferrozine reaction show that some of this nonheme iron on IOM reacts slowly and is probably in the form of ferritin, but most (72% +/- 18%) reacts rapidly and is in the form of some other biologic chelate. The latter iron compartment is removed by deferoxamine and by treatment of IOM with phospholipase D, which suggests that it represents an abnormal association of iron with polar head groups of aminophospholipids. The biologic feasibility of such a chelate was demonstrated by using an admixture of iron with model liposomes. Even in the presence of tenfold excess adenosine diphosphate, iron partitions readily into phosphatidylserine liposomes; there is no detectable association with phosphatidylcholine liposomes. To examine the bioavailability of membrane iron, we admixed membranes and t-butylhydroperoxide and found that sickle membranes show a tenfold greater peroxidation response than do normal membranes. This is not due simply to a deficiency of vitamin E, and this is profoundly inhibited by deferoxamine. Thus, while thiol oxidation in sickle membranes previously was shown to correlate with heme iron, the present data suggest that lipid peroxidation is related to nonheme iron. In control studies, we did not find this pathologic association of nonferritin, nonheme iron with IOM prepared from sickle trait, high-reticulocyte, postsplenectomy, or iron-overloaded individuals. These data provide additional support for the concept that iron decompartmentalization is a characteristic of sickle RBCs. 相似文献
10.
M P Slade A M Brooks W E Gillies 《Australian and New Zealand journal of ophthalmology》1989,17(4):445-450
Two cases are reported: a father and son with a new syndrome consisting of a severe congenital glaucoma associated with a form of palmoplantar keratoderma showing features of mutilating palmoplantar keratoderma. Both the glaucoma and keratoderma may be attributed to an autosomal dominantly inherited genetic mutation of a single chromosome affecting two tissues of neural crest origin, the ectodermal tissues of the hands and feet and the cranial mesenchyme from which the tissues of the chamber angle develop. Elucidation of the precise chromosomal abnormality causing these defects may help in understanding the inheritance and aetiology of glaucoma. 相似文献