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Rotjanee Wongnoi Nawaporn Penvieng Panthong Singboottra Doungnapa Kingkeow Peninnah Oberdorfer Pannee Sirivatanapa Sakorn Pornprasert 《Indian pediatrics》2013,50(6):567-572
Objectives
To investigate the effects of antiretroviral (ARV) drugs on hematological parameters and thymic function in HIVuninfected newborns of HIV-infected mothers.Study design
Cross sectional study.Setting
Chiang-Mai University Hospital, Chiang-Mai, Thailand.Participants/Patients
49 HIV-uninfected and 26 HIV-infected pregnancies.Methods
Cord blood samples of newborns from HIV-uninfected and HIV-infected mothers were collected. Hematological parameters were measured using automatic blood cell count. T-cell receptor excision circles (TRECs) levels in cord blood mononuclear cells (CBMCs), CD4+ and CD8+ T-cells were quantified using real-time PCR.Main Outcome Measures
Hemotological parameters and thymic function.Results
Newborn of HIV-infected mother tended to have lower mean levels of hemoglobin than those of HIV-uninfected mother (137 ± 22 vs 146 ± 17 g/L, P = 0.05). Furthermore, mean of red blood cell (RBC) counts and hematocrit and median of TRECs in CD4+ T-cells in the newborns of the former were significantly lower than those of the latter [3.6 ± 0.7 vs 4.8 ± 0.6 × 1012 cells/L, P <0.001; 0.40 ± 0.07 vs 0.46 ± 0.05 L/L, P <0.001 and 0.53 (IQR: 0.03–5.76) vs 13.20 (IQR: 2.77–27.51) × 10?3 pg/μL, P = 0.02, respectively].Conclusion
ARV drugs altered hematological parameters and thymic function (TRECs CD4+ T-cells) in HIV-uninfected newborns of HIV-infected mothers. 相似文献2.
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