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排序方式: 共有178条查询结果,搜索用时 31 毫秒
1.
Reinoud W. Brouwer Tijs S. C. Jakma Sita M. A. Bierma-Zeinstra Abida Z. Ginai Jan A. N. Verhaar 《Acta orthopaedica》2003,74(5):565-568
The whole leg radiograph (WLR), the standard technique for determining axial alignment, is usually taken in a standing position, although some prefer the supine position. To determine the difference between these two positions, we performed a standing and a supine WLR in 20 patients with a varus alignment. We found an average of 2 degrees more varus deviation in the standing position than in the supine position. 相似文献
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Kamp Tamara Brouwer Sandra Hylkema Tjerk H. van Beveren Jan Rijk Paul C. Brouwer Reinoud W. Stevens Martin 《Journal of occupational rehabilitation》2022,32(2):295-305
Journal of Occupational Rehabilitation - Purpose Both personal and work-related factors affect return to work (RTW) after total knee arthroplasty (TKA) and total hip arthroplasty (THA). Little is... 相似文献
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ABSTRACT: BACKGROUND: Socioeconomic inequalities in cardiovascular disease are pervasive, yet much remains to be understood about how they originate. The objective of this study was to explore the relations of socioeconomic status to lipid and glucose metabolism as indicators of cardiovascular health in 5-6 year olds. Additionally to explore the explanatory role of maternal factors, birth outcome, and child factors. METHODS: In 1308 5-6 year old ethnic Dutch children from the ABCD cohort study, lipids (cholesterol, LDL, HDL, triglycerides), glucose and C-peptide were measured after an overnight-fast. RESULTS: There were no differences in cholesterol, HDL, LDL, and triglycerides between socioeconomic groups, as indicated by maternal education and income adequacy. However, children of low educated mothers had on average a higher glucose (beta = 0.15; 95% confidence interval (CI) 0.03 - 0.27), logC-peptide (beta = 0.07; 95% CI 0.04 - 0.09), and calculated insulin resistance (HOMA-IR) (beta = 0.15; 95% CI 0.08 - 0.22) compared to children of high educated mothers. Only childhood BMI partly explained these differences (models controlled for age, height, and sex). CONCLUSIONS: The socioeconomic gradient in cardiovascular risk factors seems to emerge in early childhood. In absence of underlying mechanisms these empirical findings are relevant for public health care and further explanatory research. 相似文献
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Luthman J Hoebeek FE Maex R Davey N Adams R De Zeeuw CI Steuber V 《Cerebellum (London, England)》2011,10(4):667-682
Neurons in the cerebellar nuclei (CN) receive inhibitory inputs from Purkinje cells in the cerebellar cortex and provide the
major output from the cerebellum, but their computational function is not well understood. It has recently been shown that
the spike activity of Purkinje cells is more regular than previously assumed and that this regularity can affect motor behaviour.
We use a conductance-based model of a CN neuron to study the effect of the regularity of Purkinje cell spiking on CN neuron
activity. We find that increasing the irregularity of Purkinje cell activity accelerates the CN neuron spike rate and that
the mechanism of this recoding of input irregularity as output spike rate depends on the number of Purkinje cells converging
onto a CN neuron. For high convergence ratios, the irregularity induced spike rate acceleration depends on short-term depression
(STD) at the Purkinje cell synapses. At low convergence ratios, or for synchronised Purkinje cell input, the firing rate increase
is independent of STD. The transformation of input irregularity into output spike rate occurs in response to artificial input
spike trains as well as to spike trains recorded from Purkinje cells in tottering mice, which show highly irregular spiking
patterns. Our results suggest that STD may contribute to the accelerated CN spike rate in tottering mice and they raise the
possibility that the deficits in motor control in these mutants partly result as a pathological consequence of this natural
form of plasticity. 相似文献
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Nolan S. Hartkamp Reinoud P. H. Bokkers H. Bart van der Worp M. J. P. van Osch L. Jaap Kappelle Jeroen Hendrikse 《European radiology》2011,21(4):875-881
Objective
To investigate the influence of internal carotid artery (ICA) stenosis on the distribution of blood flow to the caudate nucleus, lentiform nucleus, and thalamus. 相似文献9.
Synaptic pathways in neural microcircuits 总被引:7,自引:0,他引:7
The functions performed by different neural microcircuits depend on the anatomical and physiological properties of the various synaptic pathways connecting neurons. Neural microcircuits across various species and brain regions are similar in terms of their repertoire of neurotransmitters, their synaptic kinetics, their short-term and long-term plasticity, and the target-specificity of their synaptic connections. However, microcircuits can be fundamentally different in terms of the precise recurrent design used to achieve a specific functionality. In this review, which is part of the TINS Microcircuits Special Feature, we compare the connectivity designs in spinal, hippocampal, neocortical and cerebellar microcircuits, and discuss the different computational challenges that each microcircuit faces. 相似文献
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This study was based on the higher prevalence of anxiety disorders in women than in men, and on the finding that early adverse experiences are a major risk factor for the development of anxiety disorders later in life. The object of this study was to investigate in rats, the sensitivities of the light-enhanced startle (LES) and fear-potentiated startle (FPS) paradigms to sex differences and to determine the effects of maternal separation (MS) on the baseline startle magnitude and potentiated startle response in these paradigms. Pups in the MS group were separated daily from their mother for 180 min/day from postnatal day 2 (PND2) to PND14. Control litters remained undisturbed. The adult male and female progeny were tested in the FPS and LES. As predicted, females showed a significantly greater potentiation of startle than males in the FPS, and a strong trend towards greater startle potentiation in the LES. Contrary to predictions, MS had no effect on startle potentiation in the FPS and severely disrupted LES in female, but not male rats. The observed sex differences add to the validity of the FPS and LES as animal paradigms of fear and anxiety. The findings indicate that these paradigms can be used to study the biological basis of sex differences in fear and anxiety. In contrast, the effects of MS on startle potentiation argue against the idea that MS provides a robust model for the predicted influences of early adverse effects on these startle potentiation measures of fear and anxiety. 相似文献