多重HPV感染患者的HPV亚型分布分析及护理

目的 探讨多重HPV感染患者的HPV亚型分布,了解不同亚型HPV的致癌性及其协同作用.方法 选取子宫颈病变与子宫颈癌患者42例.采用HPV基因芯片法,对标本进行HPV检测和分型.结果 42例患者子宫颈脱落细胞中均含有一种或一种以上高危型HPV,未见单纯低危型别的混合感染.最常见的为亚型是HPV-16(59.5%).结论 多重HPV感染以HPV16型为主,因此应重视HPV16型感染患者的治疗和随访,才能更好地预防子宫颈癌.同时加强心理护理可以提高宫颈癌患者的治疗效果.     

肱骨骨折术后骨感染并骨缺损、不愈合的临床分析

目的 探讨外支架固定加对冲引流在肱骨粉碎性骨折术后骨感染、骨缺损、不愈合的治疗中的作用.方法 在肱骨粉碎性骨折手术后并发感染、骨缺损、不愈合的患者,予以再次手术清创、拆除原内固定,装置对冲引流管以及外支架加压固定,并以两周到四周为间隔再次加压外支架固定器,直到骨折愈合.结果 总结了1999年到2007年13例手术治疗结果,术后2～4周感染得到有效控制.其中11例于4～8个月后得到骨折临床愈合,治愈率84.6%,另外2例术后6个月时无明显骨痴生长,且骨质疏松加重,予以再手术植骨内固定.1年后愈合.结论 外支架加对冲引漉在治疗肱骨骨折手术后骨感染并骨缺损、不愈合是一个行之有效的方法,它可以一期治愈感染,获得伤口愈合,而且持续加压固定有利于骨折愈合.     

Efficacy of pollen immunotherapy in seasonal allergic rhinitis

BACKGROUND: The efficacy of subcutaneous pollen immunotherapy has been documented in published double-blind, placebo-controlled studies related to treatment of seasonal allergic rhinitis. In the present study, subjective (symptom scores) and objective (nasal peak inspiratory flow, nasal smear, nasal biopsy) parameters were used to study the efficacy of pollen immunotherapy. METHODS: Forty-eight patients (32 male), mean +/- SE age 13.6 +/- 2.8 years allergic to grass-pollen participated in the present study. Patients were divided into three groups: group I, 24 patients who did not receive pollen immunotherapy; group II, 12 patients who received the build-up phase of pollen immunotherapy; and group III, 12 patients who had just finished pollen immunotherapy. With regard to objective and subjective parameters these three groups were compared. RESULTS: When group I was compared to groups II and III, the patients who had not received any immunotherapy were found to have a high daytime nasal symptoms score (P < 0.01), high daytime eye symptoms score(P < 0.01) and high night-time symptoms score (P < 0.01). In objective parameters, it was found that group I had low nasal peak inspiratory flow (P < 0.05), and a high eosinophil count in nasal smears (P < 0.05) and peripheral blood (P < 0.05). It was also demonstrated that there was an increased eosinophil infiltration (P < 0.01) and mast cell infiltration (P < 0.05) in nasal biopsy in group I. There was no significant difference between group II and group III according to these results (P > 0.05). CONCLUSIONS: Immunotherapy leads to a better clinical and histopathological prognosis in children with seasonal allergic rhinitis.     

交通伤四肢复合组织缺损的组织瓣移植修复

目的 探讨游离组织瓣移植联合应用外固定器固定骨、关节用于修复交通伤四肢组织缺损伤的临床效果. 方法对上肢和下肢交通伤造成骨、关节合并软组织、皮肤缺损等病例共36例,应用游离组织瓣移植,包括骨皮瓣、肌皮瓣、皮瓣移植,同时采用A-O管状外固定器、单侧多功能外固定器及单侧踝关节外固定器行骨关节外固定,加速骨质愈合. 结果56例移植皮瓣全部成活,骨关节缺损愈合良好,术后上肢3-6个月、下肢6-8个月拆除外固定器,肢体功能恢复满意,无畸形及骨不连接. 结论应用组织瓣移植同时以外固定器固定骨关节对交通伤肢体组织的复合性缺损进行修复和重建,具有骨关节固定简单可靠,肢体及移植组织损伤小,便于观察血运.对肢体交通伤功能得以早期训练以及护理便利起积极作用.     

外周原始神经外胚叶肿瘤/尤文肉瘤临床病理

外周原始神经外胚叶肿瘤(pPNET)/尤文肉瘤(EWS)是一类少见的、发生于中枢神经系统和交感神经系统以外神经嵴的小圆形细胞恶性肿瘤。主要由原始神经外胚层细胞组成,并可有多向分化的潜能。其免疫表型表达CD99(O13)及两项以上的神经标记物,遗传学上有染色体t(11;22)(q24;q12)的易位。笔者着重对其临床病理特征、免疫表型、病理诊断及鉴别诊断、预后等方面进行综述。     

多重HPV感染患者的HPV亚型分布分析及护理

目的 探讨多重HPV感染患者的HPV亚型分布,了解不同亚型HPV的致癌性及其协同作用.方法 选取子宫颈病变与子宫颈癌患者42例.采用HPV基因芯片法,对标本进行HPV检测和分型.结果 42例患者子宫颈脱落细胞中均含有一种或一种以上高危型HPV,未见单纯低危型别的混合感染.最常见的为亚型是HPV-16(59.5%).结论 多重HPV感染以HPV16型为主,因此应重视HPV16型感染患者的治疗和随访,才能更好地预防子宫颈癌.同时加强心理护理可以提高宫颈癌患者的治疗效果.     

高血压性左室肥大患者血浆Apelin水平的变化

目的观察高血压性左室肥大患者血桨Apelin含量的变化情况。方法选取原发性高血压患者60例,根据患者症状、体征及超声心动图结果分为高血压病伴左室肥大组（EH-LVH组,29例）及高血压病伴心力衰竭组（EH-CHF组,31例）,正常对照组（30例）则选取经体检筛查后身体健康的中老年体检者。应用酶联免疫吸附法（ELISA）测定三组人员血浆Apelin的含量。结果EH-LVH组血浆Apelin含量明显高于EH-CHF组及正常对照组（P 〈 0.01）,而EH-CHF组血浆Apelin含量低于正常对照组（P 〈 0.01）。结论Apelin可能在髙血压性左室肥大的病理生理过程中起着重要作用。     

Prenatal period to adolescence: the variable presentations of congenital cystic adenomatoid malformation

BACKGROUND: Congenital cystic adenomatoid malformation (CCAM) of the lung is a rare but potentially life-threatening pulmonary anomaly. METHODS: Seven patients operated on with the diagnosis of CCAM were reviewed to determine the clinical presentation, age at diagnosis, histopathologic types and the postoperative course. RESULTS: Cough and respiratory distress were common clinical findings in the patients in the present study. Two of the patients had congenital respiratory distress. The patient who was diagnosed at 15 years had cough, hemoptysis and anorexia for the last 4 months. One patient who received the diagnosis of CCAM prenatally was asymptomatic until she was operated on, on the 45th postnatal day. All patients but one were operated on and histopathological diagnosis was made for each of them between the ages of 4 days to 12 months. Four patients were diagnosed as having CCAM type I, and three patients had CCAM type II histopathologically. Duration of postoperative follow up was between 3 months and 15 years. Neither patient had complaints during that period. CONCLUSION: CCAM can present at different ages and in various clinical presentations. There can even be asymptomatic patients who receive their diagnosis during the prenatal period. The possibility of an underlying CCAM should be considered in infants with recurrent chest infections or persistent abnormalities on chest X-ray following an acute infection. CCAM should also be considered in cases with lung abscess, even in adolescents with no past history of pulmonary complaints.     

多重HPV感染患者的HPV亚型分布分析及护理

目的 探讨多重HPV感染患者的HPV亚型分布,了解不同亚型HPV的致癌性及其协同作用.方法 选取子宫颈病变与子宫颈癌患者42例.采用HPV基因芯片法,对标本进行HPV检测和分型.结果 42例患者子宫颈脱落细胞中均含有一种或一种以上高危型HPV,未见单纯低危型别的混合感染.最常见的为亚型是HPV-16(59.5%).结论...