Effect of a structured asthma education program on hospitalized asthmatic children: A randomized controlled study

BACKGROUND: The aim of this study was to compare the effectiveness of an intensive asthma education program (group B) with that of a standard asthma education program (group A). METHODS: A prospective randomized single blinded study was conducted in the pediatric department of a public hospital in Hong Kong. Children aged 2-15 years admitted to the pediatric department with an acute attack of asthma were recruited. A standard asthma education program (group A) or an intensive asthma education program (group B) for children were offered. The main outcome measures include the number of visits to the emergency department and the number of hospitalization for asthma during the 3 month follow-up period. RESULTS: A total of 45 children were in group A and 55 in group B. Group B had statistically significant reductions in the number of visits to the emergency department and the number of hospitalizations. Drug compliance was also significantly improved in group B. Parents' satisfaction rate was also higher in group B. CONCLUSION: The intensive asthma education program might be more cost effective than the standard asthma education program in the management of asthmatic children admitted to hospital in Hong Kong.     

麦角新鹼的层离及提取的研究

麦角为极常用的产科药物,其中所含生物鹼据文献中报告一般常见者有六对之多,而以水溶性之麦角新鹼效力最好,毒性最小.自Foster等发表用纸层离法鉴定麦角新鹼以后,才有了比较好的定性试验以肯定麦角新鹼的存在与否,但是这个方法至少需要十六到十八小时才能得到结果,时间上很不经济,因此有必要寻找一个比较快的方法.根据Brindle等用纸层离分离水不溶性生物鹼的结果,著者试用了含有缓的纸进行水溶性生物鹼的层离,用氯仿为推进剂,得到满意结果,不但麦角新鹼斑     

5-羟基色胺类似物 Ⅳ.新型抗惊厥药——2-二正丁氨甲基吲(?)的类似化合物

合成了若干2-二烷氨甲基类化合物以及3-二正丁氨甲基吲(口朶)、3-(β-二烷氨乙基)吲(口朶)和2-甲基-3-(β-二正丁氨乙基)-5-甲氧基吲(口朶),这些化合物为前文所述具有抗惊厥作用的2-二正丁氨甲基吲(口朶)的类似化合物,经初步药理评价后,探讨了化学结构与抗惊厥作用间关系,其中以2-二正丁氨甲基-3-甲基吲(口朶)作用为最强。     

PTEN抑癌基因在乳腺癌组织中的表达及其与乳腺癌微小转移灶的关系

目的:研究PTEN抑癌基因在乳腺癌组织中的表达,探讨其与乳腺癌病人的外周血、骨髓及前哨淋巴结微小转移灶之间的关系。方法:选择53例乳腺癌病人的组织标本,用免疫组织化学方法检测原发肿瘤PTEN蛋白的表达;用定量RT鄄PCR法测定原发肿瘤PTENmRNA的表达。以免疫细胞化学法检测外周血和骨髓中的微小转移灶;HE染色和免疫组织化学法检测前哨淋巴结中的微小转移灶。结果:外周血、骨髓及前哨淋巴结中微小转移灶的检出率分别是24.5%,56.6%,26.4%和41.5%。乳腺癌组织中PTEN蛋白表达呈丢失者占35.8%,后者与外周血和骨髓微小转移灶间无显著关系,而与前哨淋巴结中的微小转移密切相关(P≤0.001)。PTENmRNA的表达与外周血、骨髓及前哨淋巴结中的微小转移灶之间均无显著相关性。结论:乳腺癌组织中PTEN蛋白表达的丢失与前哨淋巴结中的微小转移有密切关系,可作为预测其早期转移的重要指标。