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排序方式: 共有97条查询结果,搜索用时 15 毫秒
1.
Ampaiwan Chuansumrit Nirobol Kanogsunthornrat Nongnuch Sirachainan Surapan Porapakpenjun Rujinee Chantarukha Sukhuma Warrasak Pakawan Wongwerawattanakoon 《Blood coagulation & fibrinolysis》2007,18(1):77-79
A negative pressure dressing to promote wound healing of purpura fulminans in a girl aged 35 days with homozygous protein C deficiency is reported. Two wounds of 11 x 11 cm2 at the abdominal wall and 14 x 14 cm2 at the left trunk were covered with sterile sponges embedded with a multiple-hole drain tube and transparent plastic film. The exposed end of the drain was then connected to the wall suction apparatus to create negative pressure at -120 mmHg. The dressing was changed every 2 days. Within 4-6 weeks, the wounds were completely healed and skin grafting was not required. 相似文献
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Arkom Nongnuch Kwanpeemai Panorchan Andrew Davenport 《Critical care (London, England)》2014,18(3):225
Encephalopathy and altered higher mental functions are common clinical complications of acute kidney injury. Although sepsis is a major triggering factor, acute kidney injury predisposes to confusion by causing generalised inflammation, leading to increased permeability of the blood–brain barrier, exacerbated by hyperosmolarity and metabolic acidosis due to the retention of products of nitrogen metabolism potentially resulting in increased brain water content. Downregulation of cell membrane transporters predisposes to alterations in neurotransmitter secretion and uptake, coupled with drug accumulation increasing the risk of encephalopathy. On the other hand, acute brain injury can induce a variety of changes in renal function ranging from altered function and electrolyte imbalances to inflammatory changes in brain death kidney donors. 相似文献
4.
Sasanakul W Chuansumrit A Ajjimakorn S Krasaesub S Sirachainan N Chotsupakarn S Kadegasem P Rurgkhum S 《The Southeast Asian journal of tropical medicine and public health》2003,34(4):891-898
The cost-effectiveness of carrier detection and prenatal diagnosis for hemophilia at the International Hemophilia Training Center, Bangkok, Thailand was studied. From 1991 to 2002, 209 females from 124 families with hemophilia A and B were included. There were 180 hemophilia A carriers and 29 hemophilia B carriers which could be classified into 78 obligate and 131 possible carriers. The phenotypic analysis for possible carriers involved the determination of levels of factor VIII or IX clotting activity (FVIII:C, FIX:C) and the ratio of FVIII:C and von Willebrand factor antigen. The result revealed that 49 females (37.4%) were diagnosed as carriers, 65 females (49.6%) were normal and 17 females (13%) were undetermined. Additional genotypic analysis was provided to 46 families with 74 females with obligate, proven or undetermined carriers within the reproductive life. The polymorphisms associated with factor VIII and IX genes were used including Bcl I for the factor VIII gene and combined use of Mse I, Sal I, Nru I, Hha I and Dde I for the factor IX gene. The informative rate was 59.4% (44/74). Consequently, 12 prenatal diagnoses for fetus at risk were performed. Sex determination was initially determined and followed by the diagnosis of hemophilia through informative gene tracking and/or the measurement of fetal levels of FVIII:C or FIX:C. The result revealed that 3 male fetuses were affected. The total cost of carrier detection and prenatal diagnosis that the families had to pay in the government hospital was 238,600 Baht (US dollars 5,965). It was compared to the estimated cost of minimal replacement therapy using lyophilized cryoprecipitate for the survival time of 30 years in one patient with hemophilia of 1,012,500 Baht (US dollars 25,312.5). The cost of prevention was much less than the replacement therapy. In conclusion, it is cost-effective to establish the service for carrier detection and prenatal diagnosis for hemophilia especially in developing countries with limited health resources. 相似文献
5.
Napadol Siritip Arkom Nongnuch Thanate Dajsakdipon Charat Thongprayoon Wisit Cheungprasitporn Jackrapong Bruminhent 《The American journal of the medical sciences》2021,361(3):352-357
BackgroundMulti-drug resistant organisms have been emerging among kidney transplant (KT) recipients with bloodstream infections (BSI). The investigation for epidemiology, risk factors and outcome of these infections following KT was initiated.Materials and MethodsA retrospective study of all adult KT recipients who developed a BSI within the first year after KT in 2016 at a single transplant center was conducted. The cumulative incidence of BSI was estimated with Kaplan-Meier methodology. Clinical characteristics and outcome were extracted. Risk factors were analyzed with Cox proportional hazards models.ResultsAmong 171 KT recipients, there were 26 (15.2%) episodes of BSI. Fifty-nine percent were men and the mean ± SD age was 43 ± 12 years. The cumulative incidence of BSIs was 10.1% at 1 month, 13.5% at 6 months, and 15.2% at 12 months. Gram-negative bacteria were responsible for 92% of BSIs, Escherichia coli was the most common pathogen (65%) followed by Klebsiella pneumoniae (11%). Among those, 71% were resistant to extended-spectrum cephalosporins. The genitourinary tracts were the predominant source of BSIs (85%). The second kidney transplantation (HR, 4.55; 95% CI, 1.24–16.79 [P = 0.02]) and receiving induction therapy (HR, 3.05; 95% CI, 1.15‐8.10 [P < 0.03]) were associated with BSI in a multivariate analysis. One patient (4%) developed allograft rejection, allograft failure and death from septic shock.ConclusionsOne out of six KT recipients could develop BSI from gram-negative bacteria within the first year after transplant, particularly in those that received the second transplantation or induction therapy. 相似文献
6.
Winai Chaidaroon Napaporn Tananuvat Pimploy Chavengsaksongkram Nongnuch Vanittanakom 《Case reports in ophthalmology》2015,6(1):82-87
Purpose
To report 2 unusual cases of fungal keratitis due to Fonsecaea pedrosoi.Methods
Two patients were diagnosed with Fonsecaea pedrosoi keratitis. Their files were reviewed for predisposing factors, clinical characteristics, microbiological study, treatment, and outcome.Results
Two consecutive patients presented with brownish pigmented corneal ulcers in their eyes after sustaining eye trauma from vegetative matter. In both cases, corneal scrapings were collected for microscopic examination and culture. Dematiaceous hyphae were seen on the smears, and dark pigmented colonies grew on the culture media, identified as F. pedrosoi. Both patients were treated and cured with combined topical antifungal agents and oral itraconazole. The first patient required an amniotic membrane patch, while the second received an intracameral amphotericin B injection.Conclusions
Pigmented infiltrates can be an important diagnostic clue, but a microscopic evaluation and culture are required to obtain an accurate diagnosis of Fonsecaea keratitis. The prompt diagnosis and combined antifungal treatment can prevent morbidity associated with this fungal infection.Key Words: Fonsecaea pedrosoi, Dematiaceous fungus, Keratitis, Chromoblastomycosis 相似文献7.
Chatchawan Silpakit Suwanee Sirilerttrakul Manmana Jirajarus Thitiya Sirisinha Ekaphop Sirachainan Vorachai Ratanatharathorn 《Quality of life research》2006,15(1):167-172
The objective of this study was to assess the psychometric properties of the Thai version of the European Organization for
Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) version 3.0. The questionnaire was completed
by 310 cancer patients during their follow-up at 2 teaching hospital oncology clinics. About 70% of participants had advanced
stage of cancer and 72% had been receiving chemotherapy. Cronbach’s α coefficients of the six scales were above 0.7, except for cognitive and social function scales. All test–retest reliability
coefficients were high. Multitrait scaling analysis showed that all item-scale correlation coefficients met the standards
of convergent and discriminant validity. Most scales and items could discriminate between subgroups of patients with different
clinical status assessed with the Eastern Cooperative Oncology Group (ECOG) scale. The results suggested that the EORTC QLQ-C30
and the Functional Assessment of Cancer Therapy – General (FACT-G) measured different aspects of quality of life and should
be independently used. Testing psychometric properties of the EORTC QLQ-C30 in heterogeneous diagnostic group yield similar
results as found in homogeneous group. These results support that the EORTC QLQ-C30 (version 3.0) has proven to be a reliable
and valid measure of the quality of life in Thai patients with various types of cancer. 相似文献
8.
Pakakasama S Hongeng S Chaisiripoomkere W Chuansumrit A Sirachainun N Jootar S 《Journal of pediatric hematology/oncology》2004,26(4):248-252
To determine the outcome of children with homozygous beta-thalassemia (beta/beta) and severe beta-thalassemia/hemoglobin E disease (beta/E) who underwent allogeneic peripheral blood stem cell transplantation (PBSCT). The authors conducted a cohort study of allogeneic PBSCT in beta/beta and beta/E patients who had 6/6 or 5/6 HLA-matched sibling donors. All patients received a conditioning regimen including busulfan and cyclophosphamide, except one who received busul-fan and cyclophosphamide plus antithymocyte globulin. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine A and methotrexate for eight patients and cyclosporine and mycophenolate mofetil for one patient. Donors received G-CSF for 4 days before leukapheresis collections. There were five beta/beta and four beta/E patients in this study. The median age was 9 years (range 1.5-10 years). The median CD34+ cell count was 7.4 x 10(6) cells/kg recipient body weight. All patients achieved neutrophil and platelet engraftment with a median time of 15 days and 21 days respectively. Acute GVHD grade 2 to 4 appeared in four patients (grade 2, n = 3; grade 4, n = 1). Three patients developed chronic GVHD (limited, n = 2; extensive, n = 1). All patients were alive with a median follow-up time of 23 months (range 7-52 months). Neither graft failure nor graft rejection was observed. Allogeneic PBSCT is feasible for children with beta/beta and beta/E, although the incidence of GVHD was apparently high compared with bone marrow transplant study in Thais. 相似文献
9.
Inpankaew T Jiyipong T Pinyopanuwat N Chimnoi W Thompson RC Jittapalapong S 《The Southeast Asian journal of tropical medicine and public health》2010,41(4):770-775
The aims of this study were to determine the prevalence of Cryptosporidium spp in dairy cows in central Thailand and to investigate the genotype of Cryptosporidium spp in this population. A total of 200 fecal samples from dairy cows were collected and examined by the acid-fast staining technique and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The prevalence of Cryptosporidium infection in dairy cows was 7% (95% CI 3.5-10.5) by acid-fast staining, and 15.5% (95% CI 10.5-20.5) by PCR-RFLP. This is the first report of genetic identification of the C. parvum bovine genotype in dairy cows in Thailand. PCR-RFLP analysis showed all positive samples were C. parvum (bovine genotype). C. andersoni was not found in this study. The only significant risk factor for Cryptosporidium infection in dairy cows was age. Calves less than 2 months old were more frequently infected by Cryptosporidium than others (OR 13.82, 95% CI 3.67-51.97, p = 0.001). Cattle may be a potential source of human cryptosporidiosis. 相似文献
10.