全文获取类型
收费全文 | 9798篇 |
免费 | 740篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 273篇 |
妇产科学 | 209篇 |
基础医学 | 1682篇 |
口腔科学 | 77篇 |
临床医学 | 927篇 |
内科学 | 2101篇 |
皮肤病学 | 204篇 |
神经病学 | 1253篇 |
特种医学 | 266篇 |
外科学 | 1000篇 |
综合类 | 24篇 |
一般理论 | 2篇 |
预防医学 | 988篇 |
眼科学 | 112篇 |
药学 | 655篇 |
中国医学 | 7篇 |
肿瘤学 | 770篇 |
出版年
2024年 | 8篇 |
2023年 | 98篇 |
2022年 | 147篇 |
2021年 | 323篇 |
2020年 | 180篇 |
2019年 | 238篇 |
2018年 | 333篇 |
2017年 | 194篇 |
2016年 | 267篇 |
2015年 | 308篇 |
2014年 | 432篇 |
2013年 | 564篇 |
2012年 | 837篇 |
2011年 | 830篇 |
2010年 | 427篇 |
2009年 | 445篇 |
2008年 | 679篇 |
2007年 | 698篇 |
2006年 | 660篇 |
2005年 | 713篇 |
2004年 | 559篇 |
2003年 | 551篇 |
2002年 | 455篇 |
2001年 | 60篇 |
2000年 | 44篇 |
1999年 | 70篇 |
1998年 | 95篇 |
1997年 | 68篇 |
1996年 | 48篇 |
1995年 | 44篇 |
1994年 | 38篇 |
1993年 | 26篇 |
1992年 | 18篇 |
1991年 | 20篇 |
1990年 | 14篇 |
1989年 | 3篇 |
1988年 | 8篇 |
1987年 | 4篇 |
1986年 | 10篇 |
1985年 | 5篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1980年 | 5篇 |
1978年 | 4篇 |
1973年 | 5篇 |
1972年 | 2篇 |
1967年 | 3篇 |
1964年 | 2篇 |
1961年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
Isabelle Mermet MD ; Nathalie Pottier MSc ; Jean Marie Sainthillier MSc ; Carole Malugani MSc ; Sandrive Cairey-Remonnay MD ; Stéphane Maddens PhD ; Didier Riethmuller MD PhD ; Pierre Tiberghien MD PhD ; Philippe Humbert MD PhD ; François Aubin MD PhD 《Wound repair and regeneration》2007,15(4):459-464
Amniotic membrane (AM), the most internal placental membrane, has unique properties including antiadhesive effects, bacteriostatic, wound protection and pain-reduction properties, as well as epithelialization initialization capacities. Furthermore, AM is widely available and less costly than other bioengineered skin substitutes. In a prospective pilot study, we evaluated the safety, feasibility, and the effects on healing of AM graft in 15 patients with chronic venous leg ulcers. AM grafts were prepared from placentas harvested during cesarean section. All grafted AM had adhered to the wound bed 7 days after being applied with a 100% engraftment rate. The percentage of granulation tissue increased significantly (from 17% on day 0 to 69% on day 14, p<0.0001), along with a significant decrease of fibrinous slough (from 36% at day 0 to 16% at day 14, p<0.001). A significant clinical response occurred in 12 patients (80%) including complete healing (20%) in three during the 3-month follow-up period. The ulcer surface area decreased significantly from a mean value (+/- standard deviation) of 4.59 +/- 2.49 cm(2) at baseline to 2.91+/-2.01 cm(2) on day 30 (p<0.001). All patients experienced a significant reduction of ulcer-related pain rapidly after AM transplantation. No adverse events were recorded. AM transplantation seems to function as a safe substrate, promoting proper epithelialization while suppressing excessive fibrosis. Further advantages of biotherapy with AM are its easy and low-cost production, and that it can be applied as an ambulatory treatment without immobilization. AM transplantation may thus be considered to be an alternative method for treating chronic leg ulcers. 相似文献
7.
Christian Mazel Jean-Pierre Elsig Pierre Kehr Nathalie Richard 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2007,17(6):617-623
The eleventh Argos international symposium was held on 25 and 26 January 2007 at Maison des Arts et Métiers, Paris. Regular attendees were present as well as newcomers from around the world. 相似文献
8.
Jean-Fran ois Marini Fran oise Pons Jocelyne Leger Nathalie Loffreda Monique Anoal Martine Chevallay Michel Fardeau Jean J. Leger 《Neuromuscular disorders : NMD》1991,1(6):397-409
The expression of MHC isoforms in the skeletal muscles of nine patients with Duchenne muscular dystrophy (DMD) (from 2.5 to 15 yr of age) and three DMD carriers was studied using different specific anti-MHC MAbs. We also analyzed muscle fiber size and fiber reactivity with acridine orange and/or with a surface antigen marker. One-quarter of all fibers of DMD patients, or less with age, were of normal size and contained only adult slow MHC. Half of the muscle fibers contained adult and developmental MHCs. Only half of these fibers were representative of an active regenerative process. MHC co-expression also altered the proportion of normal fast or slow fibers. Adult fast MHCs were expressed as unique MHC only in small and very small fibers in the oldest DMD patients. In DMD carrier muscles, the greatest alterations in MHC expression were observed in patients with the most reduced dystrophin expression. However, MHC changes in dystrophin-positive fibers were similar to those observed in dystrophin-free fibers. In conclusion, disruptions or delays in the switching of all genes coding for adult fast and slow MHC and developmental MHC coincided with dystrophin deletion and with perturbations in its expression. 相似文献
9.
Ronald A. Kramp Nathalie Caron Jacqueline Genard Christelle Lejeune Egils Gulbis Arnold Herman 《European journal of pharmacology》1997,330(2-3):165-176
Renal hemodynamics were studied using an electromagnetic perivascular flow sensor in anesthetized rats injected i.v. with vehicle, 5 or 10 mg/kg body weight (b.w.) sulindac. No hemodynamic changes occurred with vehicle (n=6), but mean arterial pressure was significantly decreased (by 15 mmHg) with sulindac (n=12). In the 5 mg/kg b.w. sulindac group (n=7), renal blood flow progressively and significantly increased from 7.88±0.36 to 8.98±0.58 ml/min, except during concomitant intrarenal infusion of 3 mg/kg b.w. per h proadifen (n=7). The pressure limits for efficient and no renal blood flow autoregulation remained unchanged (approx. 100 and 80 mmHg, respectively). In the 10 mg/kg b.w. sulindac group (n=5), renal blood flow did not change but autoregulatory pressure limits were lowered by 10 mmHg 2 h after treatment (P<0.025). Also, Na+ retention was marked. Prostanoid excretion in urine was significantly reduced with either dose but basal plasma renin activity was not (about 8 ng/ml per h; n=15). When plasma renin activity was enhanced after a reduction in renal perfusion pressure (n=21), it was decreased from 11.5±1.2 to 7.4±0.2 ng/ml per h only by 10 mg/kg b.w. sulindac (P<0.05; n=6). In conclusion, differential effects of sulindac on renal hemodynamics, Na+ excretion and plasma renin activity were demonstrated. Renal hemodynamic changes could be related in part to the cytochrome P-450 arachidonic acid pathway. 相似文献
10.