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1.
SYUJI TAKEI NOBUAKI MAENO MASAHIKO SHIGEMORI HIROYUKI IMANAKA HIROSUMI MORI YASUHITO NEROME SYOKO KANEKURA TOMOKO TAKEZAKI MASASHI HOKONOHARA KOICHIRO MIYATA SATOSHI FUJIKAWA 《Pediatrics international》1997,39(2):250-256
Marked advances have been made in the past decade in the management of adults with systemic lupus erythematosus (SLE). Therefore, a nationwide retrospective survey was conducted between 1980 and 1994 to investigate the clinical manifestations of SLE in Japanese children and adolescents. Questionnaires were sent to 340 hospitals. Of 405 patients reported by 176 hospitals, 373 patients, diagnosed by the criteria established by the Pediatric Study Group of the Japanese Ministry of Health and Welfare in 1985, were enrolled in the study. Forty-nine of the 354 patients (13.8%) had relatives with a connective tissue disease within the third degree of consanguinity. The frequent manifestations in 373 patients were the presence of antinuclear antibody (98.9%), immunologic disorders (93.0%), hypocomplementemia (87.1%), malar rash (79.6%) and fever (74.0%). Lupus nephritis was present in 148 of the 309 patients (47.9%) at their first visit to a clinic, and 261 of the 373 patients (70.0%) developed renal involvement during the observation period. Of 370 patients, 92 patients (24.9%) exhibited central nervous system lupus. Of 368 patients, 192 patients (52.2%) were treated by methylprednisolone pulse therapy and 148 patients (40.2%) received immunosuppressants in combination with steroid therapy at some stage during the observation period. Survival rate at 5 years from onset was 95.9%. Management of infection, coagulopathies, and central nervous system involvement is essential to improve the prognosis of SLE in Japanese children and adolescents. 相似文献
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NOBORU WATANABE MASAHIRO YOTSUKURA NOBUAKI KADOI KIMIO YASHIRO MASAMICHI SAKANOUE HIROSHI NISHIDA 《Pediatrics international》1994,36(3):329-332
An epidemiological survey was carried out to examine the present situation with respect to sudden infant death syndrome (SIDS) in Kanagawa Prefecture. Questionnaires on sudden unexpected death of infants aged < 1 year in 1990-91 were sent to the hospitals and clinics in Kanagawa Prefecture which may take care of such infants. By analysing information from 10 485 replies, 48 out of 73 reported sudden infant deaths were confirmed to be SIDS, although autopsy was not performed in 13 cases (27%). The incidence of SIDS per 1000 live births in Kanagawa Prefecture was 0.29 in 1990 and 0.31 in 1991; and if limited to autopsy cases 0.19 and 0.25, respectively. Sudden infant death syndrome cases in Japan were found to occur more frequently when infants were < 6 months old, at home and sleeping alone, but less in the winter and between midnight and early morning. There was little difference between the numbers in prone and supine sleeping positions at discovery. It was not clear whether SIDS occurred more often to babies sleeping prone than supine, because there were no controls matched with the SIDS cases. In future, continuous epidemiological surveys of SIDS in Japan should be carried out. 相似文献
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YOSHIAKI YAMADA KOGENTA NAKAMURA SHIGEYUKI AOKI TOMOHIRO TAKI HIROTO KOKUBO HIROYUKI MATSUBARA MOTOI TOBIUME NOBUAKI HONDA 《International journal of urology》2006,13(2):111-115
OBJECTIVE: To assess the clinical efficacy of endoscope-assisted minilaparotomic radical retropubic prostatectomy (EAM-RRP) compared with conventional radical retropubic prostatectomy (cRRP). METHODS: From September 2001 to December 2003, 30 patients with localized prostate cancer were treated by EAM-RRP. The surgical manipulation was performed through the wound with thoracoscopic assistance, using standard surgical instruments. In all cases, 800 mL of blood was collected from the patient for autotransfusion. For both EAM-RRP and cRRP, the internal iliac and obturator lymph nodes were dissected before the prostate removal. Clinical indicators such as operation time, blood loss, and duration of postoperative urine incontinence were analysed in the two groups. RESULTS: The postoperative period before ambulation and the duration of postoperative urine incontinence were significantly shorter after EAM-RRP than after cRRP, while no significant difference was found in operation time, blood loss, and duration of urethral catheterization. None of the cases required allotransfusion. CONCLUSION: EAM-RRP, which had a shorter postoperative period before ambulation and continence, is considered a safe and useful technique for radical prostatectomy. 相似文献
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YASUO AWAKURA MITSUO NONOMURA NORIYUKI ITOH ATSUSHI MAENO TAKUO FUKUYAMA 《International journal of urology》2003,10(5):281-283
A 75-year-old female presented with a 7-month history of intermittent macrohematuria and urinary retention. Physical examination revealed a firm, round mass on the anterior vaginal wall. The diagnosis by urethroscopy and radiological evaluation was localized urethral diverticular tumor. Pathological examination of the biopsy specimen revealed adenocarcinoma. The patient received two courses of intra-arterial and systemic chemotherapy using cisplatin, 5-fluorouracil and leucovorin, followed by radiation to the urethra. The tumor shrunk markedly after chemotherapy. The patient underwent total urethrectomy and vesicostomy. Two years after the operation, she had no evidence of recurrence. Adenocarcinoma of the female urethral diverticulum is rare and has been treated by surgery and/or radiation. The present case is the first case of it being treated by multimodality therapy including chemotherapy. 相似文献
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SHINYA TANAKA KENTARO KAMIYA NOBUAKI HAMAZAKI RYOTA MATSUZAWA KOHEI NOZAKI EMI MAEKAWA CHIHARU NODA MINAKO YAMAOKA-TOJO ATSUHIKO MATSUNAGA TAKASHI MASUDA JUNYA AKO 《Journal of cardiac failure》2018,24(11):723-732
Background
The impact of frailty on long-term prognosis in patients with heart failure (HF) remains unclear, and there is no simple and objective assessment for it. This study was performed to examine the association between frailty score and clinical outcome in elderly patients hospitalized for HF.Methods and Results
A retrospective cohort study was performed with 603 elderly patients with HF (mean age 75 ± 6 years, 378 [62.7%] men). Frailty was measured by a composite of 4 markers combined into a frailty score (possible range 0–12): gait speed, handgrip strength, serum albumin, and activities of daily living status. The patient population was divided into 2 groups with frailty score <5 (non-frail) or ≥5 (frail). The end point was all-cause mortality. Over a mean follow-up period of 1.7 ± 0.5 years, 89 patients died. After adjustment for several preexisting factors associated with prognosis, the frailty score (hazard ratio [HR] 1.11; P?=?.014) and frailty (HR 1.75; P?=?.036) were independently associated with all-cause mortality. The inclusion of frailty score significantly increased both continuous net reclassification improvement (0.341; P?=?.002) and integrated discrimination improvement (0.016; P?=?.039) for all-cause mortality.Conclusions
A simple and objective frailty score was associated with health outcome in elderly patients hospitalized for HF. 相似文献7.
目的:观察牙龈卟啉单胞菌(Porphyromonas gingivalis,P.gingivalis)对人类脐静脉血管内皮细胞(human umbilical vein endothelial cells,HUVECs)产生可溶性细胞间粘附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)的影响。方法:应用厌氧袋法培养P.gingivalis,并用其感染HUVECs,采和酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)测定培养上清中sICAM-1的含量,结果:HUVECs基础表达少量的sICAM-1;P.gingivalis剂量依赖性增强HUVECs产生sICAM-1蛋白的水平;紫外线、超声波和65℃的热处理都不能抑制P.gingivalis的作用;sICAM-1蛋白水平在P.gingivalis刺激后的4h未见改变,增高的作用从刺激后的8h开始,在12h,16h和20h继续增加。结论:活的和灭活的P.gingivalis都剂量依赖性和时间依赖性地增强HUVECs产生sICAM-1,P.gingivalis可能同样诱导牙龈血管内皮细胞表达sICAM-1,升高的sICAM-1可能参与调节牙周病炎症反应和免疫反应过程。 相似文献
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SHINJI SATOH md SHUGO OBATA md HAYASHI TANAKA md SHINJI ITO md CHIAKI ISHIZUKA md SEIKO MINOSHITA phd NOBUAKI MORITA md 《Psychiatry and clinical neurosciences》1997,51(4):223-225
Abstract There are cases in which no clear symptoms of schizophrenia are observed in a person at the time of a crime but are diagnosed to have schizophrenia after the crime due to the appearance of typical symptoms. We present psychiatric evidence of a patient who saw a bus hijacking incident on TV during several years of isolation at home after graduation from junior high school, and was then determined to hijack a bus, and carried out the crime 6 months later. The patient exhibited clear symptoms of schizophrenia 3 days after the crime. This case of a crime committed before the appearance of clear symptoms of schizophrenia was evaluated from the viewpoint of verbrecherromantik or 'criminal romance'. 相似文献
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YOHEI SOTOMI M.D. TAKAYUKI KIKKAWA KOICHI INOUE M.D. Ph.D. KOJI TANAKA M.D. YUKO TOYOSHIMA M.D. TAKAFUMI OKA M.D. Ph.D. NOBUAKI TANAKA M.D. YOICHI NOZATO M.D. YOSHIYUKI ORIHARA M.D. KATSUOMI IWAKURA M.D. Ph.D. YASUSHI SAKATA M.D. Ph.D. KENSHI FUJII M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2014,25(9):941-947
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KAZUNARI KANEKO KEN TAKAHASHI ATSUSHI UNNO MASATOSHI TAKAGI TAKESHI MARUYAMA KAORU OBINATA NOBUAKI TSUCHIHASHI NOBUKO KAWASHIRO HIROKAZU SAKAI 《Pediatrics international》1997,39(4):475-477
Two infants, 5 and 12 weeks of age, with lingual cysts were presented. Histological findings were compatible with a salivary retention cyst in one and a thyroglossal duct cyst in the other. Both infants were admitted to our hospital because of severe stridor that had developed from one to two weeks of age. Their lingual cysts were easily recognizable by simple palpation and were confirmed by non-invasive imaging techniques, such as ultrasound sonography, computed tomography and magnetic resonance imaging. Lingual cyst in infancy may be large enough to cause stridor and dyspnea, and occasionally result in sudden infant death, although once diagnosis is made a radical operation can be easily performed. Therefore, it is important that palpation in the oral cavity should be performed with all infants with persistent stridor as a part of a physical examination. 相似文献