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Anna Semaniakou Sarah Brothers Grayson Gould Mehrsa Zahiremani Jamie Paton Frederic Chappe Audrey Li Younes Anini Roger P. Croll Valerie Chappe 《Journal of cystic fibrosis》2021,20(1):154-164
Vasoactive Intestinal Peptide (VIP) is the major physiological agonist of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride channel activity. VIP functions as a neuromodulator and neurotransmitter secreted by neurons innervating all exocrine glands. VIP is also a potent vasodilator and bronchodilator that regulates exocrine gland secretions, contributing to local innate defense by stimulating the movement of water and chloride transport across intestinal and tracheobronchial epithelia. Previous human studies have shown that the rich intrinsic neuronal networks for VIP secretion around exocrine glands could be lost in tissues from patients with cystic fibrosis. Our research has since confirmed, in vitro and in vivo, the need for chronic VIP exposure to maintain functional CFTR chloride channels at the cell surface of airways and intestinal epithelium, as well as normal exocrine tissues morphology [1]. The goal of the present study was to examine changes in VIP in the lung, duodenum and sweat glands of 8- and 17-weeks old F508del/F508del mice and to investigate VIPergic innervation in the small intestine of CF mice, before important signs of the disease development. Our data show that a low amount of VIP is found in CF tissues prior to tissue damage. Moreover, we found a specific reduction in VIPergic and cholinergic innervation of the small intestine. The general innervation of the primary and secondary myenteric plexus was lost in CF tissues, with the presence of enlarged ganglionic cells in the tertiary layer. We propose that low amount of VIP in CF tissues is due to a reduction in VIPergic and cholinergic innervation and represents an early defect that constitutes an aggravating factor for CF disease progression. 相似文献
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Reza Yadollahvandmiandoab Mehrsa Jalalizadeh Keini Buosi Herney Andrs Garcia-Perdomo Leonardo Oliveira Reis 《Current oncology (Toronto, Ont.)》2022,29(9):6700
Purpose: Bladder cancer is the 13th most common cause of cancer death with the highest lifetime cost for treatment of all cancers. This scoping review clarifies the available evidence on the role of a novel therapeutic approach called immunogenic cell death (ICD) in urothelial cancer of the bladder. Methods: In accordance with the recommendations of the Joanna Briggs Institute, we searched MEDLINE (Ovid), EMBASE, CENTRAL databases, and supplemented with manual searches through the conferences, Google scholar, and clinicaltrials.gov for published studies up to April 2022. We included literature that studied molecular mechanisms of ICD and the role of certain danger-associated molecular patterns (DAMPs) in generating ICD, safety and efficacy of different ICD inducers, and their contributions in combination with other urothelial cancer treatments. Results: Oncolytic viruses, radiotherapy, certain chemo/chemo radiation therapy combinations, photodynamic therapy, and novel agents were studied as ICD-inducing treatment modalities in the included studies. ICD was observed in vitro (murine or human urothelial carcinoma) in ten studies, eight studies were performed on mouse models (orthotopic or subcutaneous), and five clinical trials assessed patient response to ICD inducing agents. The most common studied DAMPs were Calreticulin, HMGB1, ATP, and Heat Shock Proteins (HSP) 70 and 90, which were either expressed on the cancer cells or released. Conclusion: ICD inducers were able to generate lasting antitumor immune responses with memory formation in animal studies (vaccination effect). In clinical trials these agents generally had low side effects, except for one trial, and could be used alone or in combination with other cancer treatment strategies in urothelial cancer patients. 相似文献
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Jennifer Osman Jérome Lambert Marie Templé Floriane Devaux Rémy Favre Claire Flaujac Delphine Bridoux Stéphanie Marque-Juillet Fabrice Bruneel François Mignon Ernesto Diaz-Flores Véronique Hentgen Alix Greder-Belan Reza Azarian Mehrsa Koukabi Philippe Rousselot Victoria Raggueneau Benjamin Manéglier 《British journal of haematology》2020,190(5):718-722
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da Silva Junior Maurício Moreira Capibaribe Diego Moreira Avilez Natalia Dalsenter Jalalizadeh Mehrsa Dias Luiza Bortoloti Laranja Walker W. Guimarães Fabio Simões Fabiano A. Alonso João C. C. Rejowski Ronald F. Cintra Adriano Reis Leonardo O. 《International urology and nephrology》2022,54(9):2117-2123
International Urology and Nephrology - To evaluate the impact of the digital rectal exam (DRE) on PSA measurements and clinical decision-making. Healthy male volunteers between 50 and... 相似文献
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