全文获取类型
收费全文 | 3281篇 |
免费 | 211篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 111篇 |
妇产科学 | 126篇 |
基础医学 | 523篇 |
口腔科学 | 101篇 |
临床医学 | 299篇 |
内科学 | 725篇 |
皮肤病学 | 53篇 |
神经病学 | 292篇 |
特种医学 | 47篇 |
外科学 | 353篇 |
综合类 | 12篇 |
现状与发展 | 1篇 |
一般理论 | 3篇 |
预防医学 | 323篇 |
眼科学 | 17篇 |
药学 | 227篇 |
中国医学 | 15篇 |
肿瘤学 | 230篇 |
出版年
2024年 | 5篇 |
2023年 | 43篇 |
2022年 | 70篇 |
2021年 | 177篇 |
2020年 | 72篇 |
2019年 | 138篇 |
2018年 | 129篇 |
2017年 | 92篇 |
2016年 | 113篇 |
2015年 | 119篇 |
2014年 | 150篇 |
2013年 | 174篇 |
2012年 | 292篇 |
2011年 | 292篇 |
2010年 | 144篇 |
2009年 | 120篇 |
2008年 | 190篇 |
2007年 | 188篇 |
2006年 | 187篇 |
2005年 | 179篇 |
2004年 | 149篇 |
2003年 | 131篇 |
2002年 | 113篇 |
2001年 | 33篇 |
2000年 | 24篇 |
1999年 | 18篇 |
1998年 | 15篇 |
1997年 | 12篇 |
1996年 | 8篇 |
1995年 | 13篇 |
1994年 | 7篇 |
1993年 | 7篇 |
1992年 | 9篇 |
1991年 | 7篇 |
1989年 | 4篇 |
1988年 | 8篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 5篇 |
1983年 | 8篇 |
1982年 | 3篇 |
1981年 | 8篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1969年 | 2篇 |
1935年 | 2篇 |
排序方式: 共有3509条查询结果,搜索用时 15 毫秒
1.
2.
3.
Amy Paul-Ward Gary Kielhofner Brent Braveman Mara Levin 《The American journal of occupational therapy》2005,59(5):540-545
The purpose of this study was to identify perceived barriers to independent community living and employment among clients and staff members in a transitional living facility for persons with AIDS. This qualitative study used focus groups to collect these perceptions from staff members (N = 21) and clients (N = 16). Whereas staff identified both systemic and personal barriers, clients only identified systemic barriers. These findings suggest that both clients and staff recognize the types of environmental barriers to participation that have been identified by disability scholars. The findings also underscore a consequential gap between clients' exclusive emphasis on environmental barriers and staff emphasis on clients' personal barriers that impact upon participation. 相似文献
4.
Dietmar Winkler Matth?us Willeit Rainer Wolf Mara Stamenkovic Johannes Tauscher Edda Pjrek Anastasios Konstantinidis Shird Schindler Christian Barnas Siegfried Kasper 《European neuropsychopharmacology》2003,13(2):129-134
The value of a long-term treatment with clonazepam in the prophylaxis of affective disorder is discussed controversially in the scientific literature. Altogether there are only a few reports on the use of this compound as a mood stabilizer, most of them describing patients suffering from bipolar affective disorder. The aim of this investigation was to evaluate clonazepam as a phase prophylactic medication in affective disorder. We conducted a retrospective chart review in 34 out-patients of our lithium clinic (15 suffering from unipolar depression, 15 from bipolar disorder, four from schizoaffective disorder), who had been treated with clonazepam as a long-term medication. Clonazepam was either given as monotherapy, or as in the case of lithium non-responders, as adjunctive therapy. Patients with unipolar depression had significantly (P=0.026) less depressive episodes after initiation of treatment with clonazepam. Patients with bipolar disorder did not benefit from this therapy. Neither manic/hypomanic phases nor depressive episodes were reduced in this group of patients. Interestingly, clonazepam also reduced affective phases in our four schizoaffective patients on a trend level. Our results indicate that patients with unipolar depression may benefit from a maintenance treatment with clonazepam. Due to methodological limitations our results need to be replicated in controlled double-blind randomized clinical trials. 相似文献
5.
Giorgio Ciprandi Mara De Amici Simone Negrini Gianluigi Marseglia Maria Angela Tosca 《International immunopharmacology》2009,9(10):1247-1249
Two new T cell subsets may be involved in allergic rhinitis (AR) pathogenesis: Th17 and T regulatory cells, mainly producing IL-17 and TGF-β respectively. Successful Sublingual Immunotherapy (SLIT) induces relevant immunological changes, thus the aim of this study was to evaluate serum IL-17 and TGF-β levels in AR patients treated with SLIT for 2 years. Patients' blood samples were collected before initiating SLIT (baseline), three months after the end of the first pre-seasonal SLIT course, and at the end of the second pre-seasonal course. IL-17 was detectable only in the most severe allergic patients. SLIT significantly induced an increase in serum TGF-β levels. There was moreover a significant relationship between TGF-β and symptom severity and drug use at the end of the study. Therefore, this study provides clinically relevant evidence that two pre-seasonal SLIT courses may significantly affect serum TGF-β levels. 相似文献
6.
S Biasioli G D'Andrea G Micieli M Feriani D Borin S Chiaramonte A Cananzi G La Greca 《The International journal of artificial organs》1987,10(4):245-257
Serum prolactin (PRL) levels are elevated in patients with chronic renal failure (CRF) but the mechanisms responsible for these abnormalities are not fully understood. PRL secretion is undoubtedly influenced by many substances, which can be variously altered in uremia: monoamines, endogenous opiates and PTH. Our data suggest that in early renal failure PRL levels are already significantly high and the 24-h pattern of PRL secretion is significantly different from that in controls. PRL derangements could be due in mild renal failure, to unknown factors (GABA?); in severe CRF, to a major change in dopaminergic activity; in hemodialysis (HD), to a low turnover of monoamines, and in peritoneal dialysis (PD) to increased activity of serotoninergic and dopaminergic systems. 相似文献
7.
E J García Fernández R Mara?ón C Maroto E Maroto C Seri?á J L Delcán 《Revista espa?ola de cardiología》1991,44(2):115-118
We present 5 patients with cyanotic congenital heart disease in whom a pulmonary valvuloplasty was performed as palliative therapy. The patients symptoms were hypoxemic spells, very low oxygen saturation and no weight gain. The oxygenation improved and symptoms disappeared. We believe that in properly selected patients this technique represents a good therapeutic modality. 相似文献
8.
Liliane Diefenthaeler Herter Eliete Golendziner Jos Antnio Monteiro Flores Marcelo Moretto Kristhiane Di Domenico Eduardo Becker Poli Mara Spritzer 《Journal of ultrasound in medicine》2002,21(11):1237-46; quiz 1247-8
OBJECTIVE: To describe pelvic sonographic findings in girls as old as 7 years, to compare prepubertal girls with girls who had isolated thelarche or central precocious puberty, and to verify the accuracy of sonographic variables for distinguishing prepubertal girls from girls with central precocious puberty. METHODS: Ninety-six prepubertal girls and 2 reference groups (8 girls with isolated thelarche and 8 with idiopathic central precocious puberty) were included. Ovaries were classified morphologically as homogeneous, paucicystic, macrocystic, multicystic, and having isolated cysts. Receiver operating characteristic curves were used to choose the best cutoff points. RESULTS: Chronologic and bone age were correlated with uterine length, area, and volume and ovarian volume in prepubertal girls (P < .0001). Ovarian morphologic characteristics in prepubertal girls differed significantly from those of the reference groups (P < .0001). The best cutoff points were uterine length of 4.0 cm, uterine area of 4.5 cm2, uterine volume of 3.0 cm3, and ovarian volume of 1.0 cm3. CONCLUSIONS: Uterine and ovarian growth are proportional to age in prepubertal girls. Mean ovarian volume greater than 1 cm3 showed 100% sensitivity and specificity for discriminating between prepubertal girls and girls with central precocious puberty. Microcysts are common in prepubertal girls, but the presence of 6 or more follicles up to 10 mm in diameter may suggest central precocious puberty in girls younger than 8 years. 相似文献
9.
Distal radius fractures are common in children, yet complications are rare. A rarely described complication, acute volar compartmental syndrome, occurred in a 15-year-old boy. An accurate physical examination and awareness of the syndrome are essential for diagnosis. Compartmental pressures can be obtained easily and afford a rapid means of corroboration. Once the diagnosis is established, adequate decompression of all involved compartments, including carpal tunnel release, is essential. The literature is unclear regarding the etiology of this complication. There is nothing structurally intrinsic to the distal radius that should lead to a compartmental syndrome. Both the amount of soft tissue damage at the time of fracture and the mode of immobilization (excessive elevation, constricting splint, etc.) are the ultimate determinants of a successful (or unsuccessful) outcome. 相似文献
10.
G D'Andrea R Joseph A R Cananzi F Ferro-Milone S Grunfeld M Toldo M A Welch 《Functional neurology》1988,3(2):179-185
The effect of short and long-term therapy with aspirin (50 mg/day) on platelet alpha granule secretion was studied in 11 healthy controls and 57 patients suffering from transient cerebral ischemic attacks (TIA) with and without accompanying diabetes and hypertension. Plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF 4) were measured as indicators of platelet alpha granule secretion. beta-TG and PF 4 levels were increased following cerebral ischemia. Aspirin treatment failed to suppress plasma levels of both proteins when measured a month and then a year after initiation of treatment. Therefore, these proteins may be poor indicators of platelet inhibition by aspirin. 相似文献