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排序方式: 共有125条查询结果,搜索用时 296 毫秒
1.
K. OKAMURA I. KOBAYASHI K. MATSUO T. KIYOSHIMA K. YAMAMOTO A. MIYOSHI & H. SAKAI 《Histopathology》1997,31(6):540-548
Aims:
The purpose of this study is to examine the relationship between immunohistochemical localization of cathepsin D (CD), proliferating cell nuclear antigen (PCNA) and epidermal growth factor receptor (EGF-R) in 65 cases of breast carcinoma in Japanese women and traditional prognostic factors such as histological grade, lymph node status, mitotic rate and clinical stage, in order to possibly identify some indicator(s) that may be specifically associated with prognosis.
Methods and results:
Serial sections of 5-μm thick were cut from the archival formalin-fixed, paraffin-embedded tissue blocks, and processed for CD, PCNA and EGF-R immunostaining. The results were analysed by computer-based image analysis system. All samples showed a positive immunoreaction for cathepsin D in both the parenchyma and stroma. However, the staining area and intensity varied from cell to cell in the parenchyma and stroma as well as among samples. Subsequently, the evaluation of immunostaining for CD was separately performed in both the parenchyma and stroma (CDpar and CDstr, respectively) and the combination of both components (CDtotal). PCNA and EGF-R showed positive immunostaining almost exclusively in the parenchymal component of the carcinoma tissue specimens. CDtotal significantly correlated with the histological grade, PCNA index (PI), mitotic rate (MR), EGF-R and lymph node metastasis. Significant correlation was also demonstrated between CDpar and the histological grade, EGF-R and lymph node metastasis, or between CDstr and MR, EGF-R and lymph node metastasis. EGF-R correlated highly with the histological grade, MR score, lymph node metastases and recurrence-free survival.
Conclusions:
Both the CD parameters and EGF-R are valuable indicators for predicting the biological behaviour of human breast carcinoma. 相似文献
2.
Eiichiro SUGIYAMA Takayoshi IKEDA Hiroshi MAEDA Takeshi MATSUO Masaru MATSUMOTO 《Congenital anomalies》1987,27(2):85-93
Abstract True incidence of this malformation is probably greater than that reported since the definitive diagnosis has been made at autopsy in most cases. Various hypotheses on the pathogenesis of tracheal agenesis have been proposed but they are still controversial.
In this report, we present a case of tracheal agenesis with a broncho-esophageal fistula and discuss the formal genesis. 相似文献
In this report, we present a case of tracheal agenesis with a broncho-esophageal fistula and discuss the formal genesis. 相似文献
3.
ALCOHOL-RELATED SUDDEN DEATH WITH HEPATIC FATTY METAMORPHOSIS: A COMPREHENSIVE CLINICOPATHOLOGICAL INQUIRY INTO ITS PATHOGENESIS 总被引:1,自引:0,他引:1
YUZURIHA TAKEFUMI; OKUDAIRA MASAHIKO; TOMINAGA ITARU; HORI SHINGO; SUZUKI HIROMICHI; MATSUO YOSHIHIRO; SHOJI MUNESUKE; YOKOYAMA AKIRA; TAKAGI SATOSHI; HAYASHIDA MOTOI 《Alcohol and alcoholism (Oxford, Oxfordshire)》1997,32(6):745-752
To clarify the pathogenesis of the widely known but obscuresyndrome of sudden death with hepatic fatty metamorphosis observedin alcohol abusers, we have scrutinized both the clinical andpathological data of 11 subjects who died under such circumstancesbetween 1987 and 1993. Death followed several days of uninterrupteddrinking often with little dietary intake. The notable clinicalfeatures on arrival at the emergency room were disturbance ofconsciousness (11/11), hypotension (47/6), hypothermia (3/5),hypoglycaemia (8/11), metabolic acidosis (6/6), renal dysfunction(11/11), and hyperammonaemia (5/5). The common hepatic pathologywas the extensive appearance of numerous microvesicular fattydroplets in the hepatocytes together with varying degrees ofmacrovesicular fatty change; four subjects had an underlyingcirrhosis. Death undoubtedly results from a variety of metabolicdisturbances triggered by the combination of massive ethanolintake and starvation. The appearance of extensive microvesicularfatty change superimposed on macrovesicular fatty change wasconsidered to be an associated phenomenon 相似文献
4.
Diagnosis of Small Pancreatic Carcinoma 总被引:1,自引:0,他引:1
OZAKI HIDEO; ISHII KANEO; SATO TOSHIO; KARASAWA EII; KITAMURA TSUGIO; TSUCHIYA RYOICHI; KASUGAI TATSUZO; ABE MUNEAKI; UEDA MASATOSHI; TAKEUCHI TADASHI; IDEZUKI YASUO; SUZUKI TAKASHI; OKAMURA JUN; NAGAMITSU SHINGO 《Japanese journal of clinical oncology》1985,15(1):115-120
A retrospective analysis was performed to evaluate the clinicalsymptoms and abnormal test findings in small pancreatic carcinoma.Five hundred and thirty-six cases of pancreatic carcinoma withthe histology of duct cell carcinoma were collected from 14medical centers in Japan. In 440 of the cases, tumor size wasmeasured at the time of laparotomy or from the resected specimen.Three hundred and seventy-seven patients (86%) had a carcinomalarger than 3.0 cm; only 30% of these were resectable. Sixty-threepatients (14%) had a carcinoma of 3.0 cm or less, with resectabilityof 97%. Detecting a tumor of "3 cm or less" with a high probabilityof resectability is the objective of early diagnosis with theresulting possibility of a cure. In most cases these small carcinomaswere found easily when obstructive jaundice was present (73%).However, the estimated occurrence of obstructive jaundice associatedwith carcinomas of 3 cm or less was only 10% among the totalcases of pancreatic carcinoma studied. Therefore, it is necessaryfor early diagnosis to detect carcinomas of 3 cm or less presentingwithout jaundice. The symptoms of small carcinoma without jaundiceare weight loss, anorexia, upper abdominal pain, back pain anda palpable abdominal mass. Among the various available examinations,endoscopic retrograde cholangiopancreatography, computerizedtomography and ultrasonography were valuable in diagnosing thesesmall carcinomas. 相似文献
5.
IWAHASHI KAZUHIKO; NAKAMURA KAZUHIKO; SUWAKI HIROSHI; MATSUO YOSHINORI; ICHIKAWA YOSHIYUKI 《Alcohol and alcoholism (Oxford, Oxfordshire)》1994,29(6):639-642
In 45 healthy Japanese volunteers, it was found that personsheterozygous for ALDH2 (ALDH2*1/ALDH2*2), and also either heterozygousor mutant homozygous for CYP2E1 (C2/C2 or C1/C2 can drink muchmore alcohol, even with (slight) flushing, than persons heterozygousfor ALDH2 (ALDH2*1/ALDH2*2) and normal homozygous for CYP2E1(C1/C1) 相似文献
6.
A review is presented of the recent advances in: (i) clinical features, (ii) biochemistry and molecular biology of alkaline phosphatase, (iii) genetic defect in hypophosphatasia, and (iv) prenatal diagnosis. Despite the recent progress, the pathogenesis of hypophosphatasia is far from being elucidated. More clinical cases and further characterization of the alkaline phosphatase gene mutations are needed for better understanding of the clinical spectrum of the entity. 相似文献
7.
8.
The Contactless Vital Sensing System Precisely Reflects R‐R Interval in Electrocardiograms of Healthy Subjects 下载免费PDF全文
9.
IZUMI HASHIMOTO KAZUYOSHI IMAIZUMI NAOZUMI HASHIMOTO HIROSHI FURUKAWA YUKIHIRO NODA TSUTOMU KAWABE TOYOHIRO HONDA TOMOMI OGAWA MASAKI MATSUO NAOYUKI IMAI SATORU ITO MITSUO SATO MASASHI KONDO KAORU SHIMOKATA YOSHINORI HASEGAWA 《Respirology (Carlton, Vic.)》2013,18(2):340-347
Background and objective: Bronchiolitis obliterans (BO) has been reported to develop following ingestion of Sauropus androgynus (SA), a leafy shrub distributed in Southeast Asia. Little is known about direct effects of SA on airway resident cells or haematopoietic cells in vitro. Identification of the SA component responsible for the development of BO would be an important key to elucidate its mechanism. We sought to elucidate the direct effects of SA on airway resident cells or haematopoietic cells and identify the SA element responsible for the pathogenesis of BO. Methods: SA dry powder was partitioned into fractions by solvent extraction. Human and murine monocytic cells, epithelial cells and endothelial cells were cultured with SA solution or fractions eluted from SA. We also investigated the effect of SA in vivo using a murine BO syndrome (BOS) model. Results: The aqueous fraction of SA induced significant increases of inflammatory cytokine and chemokine production from monocytic lineage cells. This fraction also induced significant apoptosis of endothelial cells and enhanced intraluminal obstructive fibrosis in allogeneic trachea allograft in the murine BOS model. We found individual differences in tumour necrosis factor α (TNF‐α) production from monocytes of healthy controls stimulated by this aqueous fraction of SA, whereas it induced high‐level TNF‐α production from monocytes of patients with SA‐induced BO. Conclusions: These results suggest that an aqueous fraction of SA may be responsible for the pathogenesis of BO. 相似文献
10.
TOSHIRO HARA MUNEAKI MATSUO RYUJI TASAKI SUMIO MIYAZAKI MASAHIRO BAMBA 《Pediatrics international》1995,37(5):575-578
We evaluated the clinical significance of measurement of urinary neopterin levels in primary immunodeficiencies and persistent infections exclusively at afebrile or asymptomatic periods. Despite the examinations at afebrile or asymptomatic periods, urinary neopterin levels were elevated in some patients with primary immunodeficiencies and in patients with persistent infections of human immunodeficiency virus (HIV) or Epstein-Barr virus (EBV). Therefore, urinary neopterin measurement at afebrile periods will be useful as one of the screening tests in the detection of such disorders among children with occasional episodes of infections. 相似文献