首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3360942篇
  免费   255152篇
  国内免费   8822篇
耳鼻咽喉   45577篇
儿科学   110089篇
妇产科学   91801篇
基础医学   473759篇
口腔科学   94305篇
临床医学   308581篇
内科学   660668篇
皮肤病学   77194篇
神经病学   277557篇
特种医学   130974篇
外国民族医学   952篇
外科学   503384篇
综合类   72764篇
现状与发展   5篇
一般理论   1293篇
预防医学   265598篇
眼科学   74776篇
药学   246710篇
  11篇
中国医学   6626篇
肿瘤学   182292篇
  2019年   26115篇
  2018年   36860篇
  2017年   28286篇
  2016年   32553篇
  2015年   36721篇
  2014年   50887篇
  2013年   76878篇
  2012年   101674篇
  2011年   107861篇
  2010年   64989篇
  2009年   62221篇
  2008年   100584篇
  2007年   107094篇
  2006年   108903篇
  2005年   104705篇
  2004年   100943篇
  2003年   97344篇
  2002年   93754篇
  2001年   162034篇
  2000年   166452篇
  1999年   140026篇
  1998年   40421篇
  1997年   35956篇
  1996年   36411篇
  1995年   35393篇
  1994年   32654篇
  1993年   30546篇
  1992年   110376篇
  1991年   106575篇
  1990年   103251篇
  1989年   99390篇
  1988年   91319篇
  1987年   89729篇
  1986年   84415篇
  1985年   80666篇
  1984年   60432篇
  1983年   51151篇
  1982年   30401篇
  1981年   27237篇
  1979年   53915篇
  1978年   38324篇
  1977年   32343篇
  1976年   30025篇
  1975年   32048篇
  1974年   38034篇
  1973年   36270篇
  1972年   33884篇
  1971年   31444篇
  1970年   28927篇
  1969年   27525篇
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Quality of Life Research - The COVID-19 pandemic might add to the stressors experienced by people living with rheumatic diseases. This study aimed to examine rheumatic patients’ functional...  相似文献   
2.
Die Anaesthesiologie - Phantomschmerzen haben eine hohe Prävalenz nach Majoramputationen und sind mit einer zusätzlichen Einschränkung der Lebensqualität verbunden....  相似文献   
3.

Interstitial lung disease (ILD) represents a significant cause of morbidity and mortality in systemic sclerosis (SSc). The purpose of this study was to examine recirculating lymphocytes from SSc patients for potential biomarkers of interstitial lung disease (ILD). Peripheral blood mononuclear cells (PBMCs) were isolated from patients with SSc and healthy controls enrolled in the Vanderbilt University Myositis and Scleroderma Treatment Initiative Center cohort between 9/2017–6/2019. Clinical phenotyping was performed by chart abstraction. Immunophenotyping was performed using both mass cytometry and fluorescence cytometry combined with t-distributed stochastic neighbor embedding analysis and traditional biaxial gating. This study included 34 patients with SSc-ILD, 14 patients without SSc-ILD, and 25 healthy controls. CD21lo/neg cells are significantly increased in SSc-ILD but not in SSc without ILD (15.4 ± 13.3% vs. 5.8 ± 0.9%, p = 0.002) or healthy controls (5.0 ± 0.5%, p < 0.0001). While CD21lo/neg B cells can be identified from a single biaxial gate, tSNE analysis reveals that the biaxial gate is comprised of multiple distinct subsets, all of which are increased in SSc-ILD. CD21lo/neg cells in both healthy controls and SSc-ILD are predominantly tBET positive and do not have intracellular CD21. Immunohistochemistry staining demonstrated that CD21lo/neg B cells diffusely infiltrate the lung parenchyma of an SSc-ILD patient. Additional work is needed to validate this biomarker in larger cohorts and longitudinal studies and to understand the role of these cells in SSc-ILD.

  相似文献   
4.
5.
6.
Intratumor heterogeneity is a main cause of the dismal prognosis of glioblastoma (GBM). Yet, there remains a lack of a uniform assessment of the degree of heterogeneity. With a multiscale approach, we addressed the hypothesis that intratumor heterogeneity exists on different levels comprising traditional regional analyses, but also innovative methods including computer-assisted analysis of tumor morphology combined with epigenomic data. With this aim, 157 biopsies of 37 patients with therapy-naive IDH-wildtype GBM were analyzed regarding the intratumor variance of protein expression of glial marker GFAP, microglia marker Iba1 and proliferation marker Mib1. Hematoxylin and eosin stained slides were evaluated for tumor vascularization. For the estimation of pixel intensity and nuclear profiling, automated analysis was used. Additionally, DNA methylation profiling was conducted separately for the single biopsies. Scoring systems were established to integrate several parameters into one score for the four examined modalities of heterogeneity (regional, cellular, pixel-level and epigenomic). As a result, we could show that heterogeneity was detected in all four modalities. Furthermore, for the regional, cellular and epigenomic level, we confirmed the results of earlier studies stating that a higher degree of heterogeneity is associated with poorer overall survival. To integrate all modalities into one score, we designed a predictor of longer survival, which showed a highly significant separation regarding the OS. In conclusion, multiscale intratumor heterogeneity exists in glioblastoma and its degree has an impact on overall survival. In future studies, the implementation of a broadly feasible heterogeneity index should be considered.  相似文献   
7.
8.
9.
10.
Journal of Behavioral Medicine - Evidence supports the use of graphic warnings to educate the public about the health harms of smoking and suggests warnings eliciting negative emotional responses...  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号