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排序方式: 共有62条查询结果,搜索用时 15 毫秒
1.
Poswal P Mehta Y Juneja R Khanna S Meharwal ZS Trehan N 《Annals of cardiac anaesthesia》2004,7(1):44-50
The use of nonpulsatile flow during extracorporeal circulation remains popular despite theoretical advantages of pulsatile cardiopulmonary bypass (CPB). Pulsatile CPB is considered to be more physiological than nonpulsatile flow as the pulsatile energy ensures the patency of the vascular bed and mechanical motion of tissue fluid around the cell membrane, improves microcirculation and enhances diffusion. The purpose of this study was to compare the effect of pulsatile and nonpulsatile flow on the coagulation profile, liver and kidney function and also on the haemodynamics in patients undergoing coronary artery bypass grafting on CPB. One hundred patients between 35 and 65 years of age with normal left ventricular function were randomly divided into two equal groups: Pulsatile (P) and nonpulsatile (NP). Haematological parameters, clotting profile, renal parameters, hepatic function tests and haemodynamic variables were measured preoperatively and postoperatively at specific intervals. Surgical, anaesthetic and CPB regimen was standard in all cases. There was a decrease in platelet count during and after CPB in both groups. Coagulation profile and renal function parameters remained similar in both groups except that creatinine clearance was better in group P on the first postoperative day. Urine output was also better in group P. There was no change in liver function tests in both groups. The haemodynamic variables were comparable in both groups. The systemic vascular resistance was higher in group NP postoperatively and oxygen consumption was higher in group P post CPB. In conclusion we did not find any significant difference between pulsatile and nonpulsatile flow during CPB except the creatinine clearance and urine output were better in pulsatile group. 相似文献
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Vimal RL 《Vision research》2002,42(5):599-611
In this study, we have compared foveal SF discriminations for luminance and color-defined stimuli using two different tasks (criteria): in criterion-A, the discrimination is based on spatial (size of the stimuli) and/or spatial frequency; in criterion-B, it is based on apparent motion (contraction/expansion). We used high contrast (75%) spatially localized D6 stimuli and cosine gratings (0.25-9.5 cpd). The SF discrimination was measured by the method of constant stimuli with a two-interval forced-choice procedure. Data show that: (i) for criterion-A, the discrimination thresholds for color stimuli were lower than that for luminance stimuli at low SFs, but similar or higher at higher SFs; for criterion-B, the thresholds to chromatic stimuli were higher than that to achromatic stimuli for all SFs; (ii) SF discrimination was best at inter-stimulus-interval (ISI) of about 200 ms for color stimuli and at ISI of 0 ms for luminance stimuli; (iii) SF discrimination got better with stimulus duration and reached to plateau at 200 ms (or more) for color stimuli and at 67 ms (or more) for luminance stimuli; (iv) SF discrimination threshold (mean Delta(f)=0.19 octaves) is about one-tenth of the full bandwidth (mean=1.96 octaves) of SF tuned mechanisms and is in hyperacuity range; both (discrimination and hyperacuity) can be explained by the relative activities within a population of tuned mechanisms. We conclude that color and luminance SF discrimination thresholds have a different SF dependence. While color appears to perform better than luminance vision at low SFs, this effect is lost or even reversed at high SFs. Data imply that color and form interact, but color and motion are largely segregated (i.e. they weakly interact). 相似文献
4.
Shaheen E Lakhan Annette Kirchgessner Magdalena Hofer 《Journal of translational medicine》2009,7(1):97
Acute ischemic stroke is the third leading cause of death in industrialized countries and the most frequent cause of permanent
disability in adults worldwide. Despite advances in the understanding of the pathophysiology of cerebral ischemia, therapeutic
options remain limited. Only recombinant tissue-plasminogen activator (rt-PA) for thrombolysis is currently approved for use
in the treatment of this devastating disease. However, its use is limited by its short therapeutic window (three hours), complications
derived essentially from the risk of hemorrhage, and the potential damage from reperfusion/ischemic injury. Two important
pathophysiological mechanisms involved during ischemic stroke are oxidative stress and inflammation. Brain tissue is not well
equipped with antioxidant defenses, so reactive oxygen species and other free radicals/oxidants, released by inflammatory
cells, threaten tissue viability in the vicinity of the ischemic core. This review will discuss the molecular aspects of oxidative
stress and inflammation in ischemic stroke and potential therapeutic strategies that target neuroinflammation and the innate
immune system. Currently, little is known about endogenous counterregulatory immune mechanisms. However, recent studies showing
that regulatory T cells are major cerebroprotective immunomodulators after stroke suggest that targeting the endogenous adaptive
immune response may offer novel promising neuroprotectant therapies. 相似文献
5.
Shaheen E Lakhan Annette Kirchgessner Magdalena Hofer 《Journal of translational medicine》2009,7(1):1-11
Background
We previously reported an HLA-A24-restricted cytotoxic T-cell epitope, Survivin-2B80-88, derived from a splice variant of survivin, survivin-2B. In this report, we show a novel HLA-A24-restricted T-cell epitope, Survivin-C58, derived from a wild type survivin, and compared their immunogenicity in oral cancer patients. 相似文献6.
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More than fifty 2-(N-substituted aminoethylthio)-3-aryl-6-iodo-4(3H)-quinazolinones 2–6 have been prepared. Some of them were tested for CNS activities on mice and found to be either depressants or stimulants. 相似文献
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Andrew P. Costa PhD John P. Hirdes PhD George A. Heckman MD MSc Aparajit B. Dey MD Palmi V. Jonsson MD Prabha Lakhan RN PhD Gunnar Ljunggren MD PhD Katrin Singler MD MME Fredrik Sjostrand MD PhD Walter Swoboda MD Nathalie I.H. Wellens PhD Leonard C. Gray MD PhD 《Academic emergency medicine》2014,21(4):422-433
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Kumari R Lakhan R Kalita J Garg RK Misra UK Mittal B 《Clinica chimica acta; international journal of clinical chemistry》2011,412(13-14):1244-1248
BackgroundGABAA receptors influence the susceptibility to seizures, and variations in the receptor genes can contribute to antiepileptic drug resistance also.MethodsWe investigated the possible associations of single nucleotide polymorphisms (SNPs) present in GABRA6 c. 1512 T>C, GABRB2 c. 1412 C>T, and GABRR2 c. IVS2C>G genes of GABAA receptors in epilepsy susceptibility and drug resistance in northern Indian patients with epilepsy. After screening a total of 202 healthy controls and 401 epilepsy patients were enrolled in study. The genotyping was done by PCR-RFLP methods.ResultsThe GABRA6 c. 1512 T>C, polymorphism was conferring risk for epilepsy susceptibility for TC (P = 0.018), CC (P = 0.0001) genotype and for C allele (P = 0.0002). Another polymorphism GABRB2 c. 1412 C>T was also conferring high risk for epilepsy susceptibility CT (P = 0.012), TT (P = 0.778) genotype and for variant T allele (P = 0.034) but was not associated with drug resistance. No association was found with epilepsy susceptibility or with drug resistance in case of GABRR2 c. IVS2C>G gene polymorphism.ConclusionOverall, our findings suggest significant involvement of alpha (GABRA6) and beta (GABRB2) subunits of GABAA receptor in epilepsy susceptibility in north Indian population. 相似文献