全文获取类型
收费全文 | 1873篇 |
免费 | 212篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 49篇 |
妇产科学 | 102篇 |
基础医学 | 278篇 |
口腔科学 | 17篇 |
临床医学 | 173篇 |
内科学 | 409篇 |
皮肤病学 | 12篇 |
神经病学 | 132篇 |
特种医学 | 199篇 |
外科学 | 208篇 |
综合类 | 44篇 |
一般理论 | 1篇 |
预防医学 | 67篇 |
眼科学 | 28篇 |
药学 | 166篇 |
中国医学 | 14篇 |
肿瘤学 | 225篇 |
出版年
2023年 | 6篇 |
2022年 | 15篇 |
2021年 | 25篇 |
2020年 | 23篇 |
2019年 | 27篇 |
2018年 | 38篇 |
2017年 | 34篇 |
2016年 | 27篇 |
2015年 | 52篇 |
2014年 | 63篇 |
2013年 | 73篇 |
2012年 | 123篇 |
2011年 | 124篇 |
2010年 | 90篇 |
2009年 | 84篇 |
2008年 | 101篇 |
2007年 | 103篇 |
2006年 | 81篇 |
2005年 | 89篇 |
2004年 | 94篇 |
2003年 | 82篇 |
2002年 | 72篇 |
2001年 | 63篇 |
2000年 | 65篇 |
1999年 | 66篇 |
1998年 | 24篇 |
1997年 | 30篇 |
1996年 | 37篇 |
1995年 | 24篇 |
1994年 | 16篇 |
1993年 | 13篇 |
1992年 | 32篇 |
1991年 | 29篇 |
1990年 | 34篇 |
1989年 | 32篇 |
1988年 | 33篇 |
1987年 | 30篇 |
1986年 | 21篇 |
1985年 | 19篇 |
1984年 | 19篇 |
1983年 | 15篇 |
1982年 | 9篇 |
1981年 | 15篇 |
1980年 | 10篇 |
1979年 | 11篇 |
1978年 | 12篇 |
1977年 | 11篇 |
1976年 | 8篇 |
1972年 | 4篇 |
1971年 | 4篇 |
排序方式: 共有2129条查询结果,搜索用时 15 毫秒
1.
S. K. Kung 《Naunyn-Schmiedeberg's archives of pharmacology》1930,155(3-6):295-330
2.
HIPDM single photon emission computed tomography brain imaging in partial onset secondarily generalized tonic-clonic seizures 总被引:3,自引:3,他引:0
HIPDM-Single photon emission computed tomography brain imaging was performed during interictal and ictal stages in three patients with complex partial seizures and secondarily generalized tonic-clonic seizures. In all three patients, interictal studies demonstrated decreased regional cerebral perfusion (rCP) and ictal studies showed increased rCP in the epileptogenic region. The demonstration of focal hyperperfusion by SPECT performed during secondarily generalized tonic-clonic seizures suggests that rCP in the epileptic focus remains higher than in other cerebral regions during immediate postictal stages, even in secondarily generalized seizures. 相似文献
3.
4.
5.
Mulkerrin EC; Clark BA; Epstein FH 《QJM : monthly journal of the Association of Physicians》1997,90(6):411-415
We studied blood pressure and natriuretic responses to acute salt loading,
and the effect of non-steroidal anti-inflammatory agents on these
responses, in five healthy normotensive women aged 65 to 71 years. Five
women aged 25 to 31 years acted as controls. Intravenous saline loading,
with and without prior ingestion of ibuprofen, was 15 ml/kg/h for 3 h.
Baseline blood pressures were higher in the elderly. Saline infusion
without ibuprofen raised systolic blood pressure (SBP) by about 25 mmHg in
the older group only. Ibuprofen increased baseline SBP in the elderly (129
+/- 6 vs. 116 +/- 5 mmHg, p < 0.05). Saline loading after ibuprofen
again raised blood pressure by about 25 mmHg in the elderly only. The
elderly group showed markedly increased sodium excretion during saline
loading, but this was reduced by ibuprofen. Ibuprofen had no effect on SBP
or sodium excretion in controls. Ageing appears to increase susceptibility
to salt retention and hypertension from non-steroidal anti-inflammatory
agents.
相似文献
6.
Acute thoracic aortic dissection has a high mortality if untreated, so the diagnosis must be rapidly made if mortality is to be lowered significantly. Multiple imaging techniques are often used. This retrospective study from 1988 to 1993 assesses the usefulness in diagnosis of chest X-rays, computed tomography (CT) scanning, aortography, magnetic resonance imaging (MRI), trans-thoracic (TTE) and trans-oesophageal (TOE) echocardiography. Forty-two patients with a final clinical diagnosis of dissection were studied. The diagnosis was confirmed in 16 (13 at surgery and three at autopsy). Three died with dissection given as the only cause for death. Chest X-ray abnormalities were seen in all 19 patients with surgery or death from dissection, with a widened mediastinum and/or dilated aorta being present in 17. In the group of 16 patients with surgery or autopsy proof, CT scans found dissections in 9 of 12 patients studied and correctly classified the type in only five. Aortography was performed in five, with accurate depiction of dissection and type in all. TTE found dissections in three of eight patients imaged by this method. MRI and TOE were performed each on two patients, with accurate depiction of dissection and type in each. Because of the relatively low sensitivity of CT scanning in defining aortic dissections Westmead Hospital is currently assessing the use of TOE as the prime imaging modality prior to surgical intervention. 相似文献
7.
Radioiodinated tracers for the evaluation of dopamine receptors in the neonatal rat brain after hypoxic-ischemic injury 总被引:1,自引:0,他引:1
Amal Zouakia Sylvie Chalon Hank F. Kung Anne-Marie Dognon Elie Saliba Jean-Claude Besnard Denis Guilloteau 《European journal of nuclear medicine and molecular imaging》1994,21(6):488-492
In order to evaluate in vivo single-photon emission tomography (SPET) method of assessing cerebral function after hypoxic-ischemic injury in human neonates, we studied D1 and D2 dopamine receptors in a rat model. Seven-day-old rats underwent permanent unilateral common carotid ligation followed by exposure to 8% O2. Two weeks later, in brains with no visible loss of hemispheric volume, striatal dopaminergic receptors were studied, with [125I]TISCH and [1251]IBZM for the D1 and D2 dopamine receptors, respectively. Using [125I]TISCH, we observed no modifications of D1 receptors, but in contrast, ex vivo and in vitro autoradiographic experiments showed a 40% decrease in the striatal binding of [125I]IBZM on both the ipsilateral and the contralateral side to the carotid ligation. These alterations were detected with IBZM, a D2 dopamine receptor ligand usable for SPET imaging. Therefore, exploration of D2 receptors by SPET in human neonates suffering from perinatal hypoxia-ischemia may be valuable for the diagnosis and follow-up of cerebral function damages.
Correspondence to: D. Guilloteau 相似文献
8.
Sensitive immunoassays are essential for establishing the efficacy of recombinant vaccines to hepatitis B virus (HBV). These experimental vaccines include the PreS2 and S domains of the HBV envelope protein. To facilitate measurement of antibody against HBV PreS2, we employed the immuno-ligand assay with silicon sensor-based detection. Labeling of immune reagents with the haptens biotin and fluorescein allows adaptation to the immunofiltration light addressable potentiometric sensor (LAPS) system. A biotinylated monoclonal anti-PreS2 antibody and anti-PreS2 in clinical serum samples competitively bind in liquid phase to a fluorescein labeled PreS2 + S antigen. Streptavidin mediates the immobilization on biotinylated nitrocellulose membranes. Fluorescein mediates binding of an anti-fluorescein urease conjugate to the immune complex. Urease serves as the signal-generating component which subsequently is measured in the LAPS reader. In comparison to a competitive RIA, the immuno-ligand assay demonstrated a four-fold improved sensitivity using a smaller sample volume. The higher sensitivity resulted in earlier detection of seroconversion during a clinical vaccine study. 相似文献
9.
10.
Bojian Zheng Ming-Liang He King-Ling Wong Ching Tung Lum Leo L M Poon Ying Peng Yi Guan Marie C M Lin Hsiang-Fu Kung 《Journal of interferon & cytokine research》2004,24(7):388-390
We sought to investigate the anti-severe acute respiratory syndrome (SARS)-associated coronavirus (SCoV) activities of type I (alpha and beta) and type II (gamma) interferons (IFN) in vitro. Type I IFNs protected cells from cytopathic effects (CPE) induced by SCoV, and inhibited viral genomic RNA replication in FRhk-4 cells (measured by quantitative RT-PCR) in a dose-dependent manner. Intracellular viral RNA copies were reduced 50% by IFN-alpha at a concentration of 25 U/ml and by IFN-beta at a concentration of 14 U/ml. IFN-gamma had fewer effects on inhibition of viral infection and replication. The type I IFN receptor signaling pathway in host cells is mainly involved in the inhibition of SCoV infection and replication. Type I IFNs could be used as potential agents for anti-SARS treatment. 相似文献