全文获取类型
收费全文 | 17384篇 |
免费 | 968篇 |
国内免费 | 70篇 |
专业分类
耳鼻咽喉 | 209篇 |
儿科学 | 544篇 |
妇产科学 | 251篇 |
基础医学 | 2519篇 |
口腔科学 | 503篇 |
临床医学 | 1211篇 |
内科学 | 4015篇 |
皮肤病学 | 383篇 |
神经病学 | 1472篇 |
特种医学 | 718篇 |
外科学 | 2485篇 |
综合类 | 98篇 |
一般理论 | 1篇 |
预防医学 | 609篇 |
眼科学 | 288篇 |
药学 | 1268篇 |
中国医学 | 53篇 |
肿瘤学 | 1795篇 |
出版年
2023年 | 101篇 |
2022年 | 182篇 |
2021年 | 361篇 |
2020年 | 203篇 |
2019年 | 299篇 |
2018年 | 391篇 |
2017年 | 308篇 |
2016年 | 366篇 |
2015年 | 343篇 |
2014年 | 490篇 |
2013年 | 604篇 |
2012年 | 908篇 |
2011年 | 942篇 |
2010年 | 535篇 |
2009年 | 525篇 |
2008年 | 836篇 |
2007年 | 958篇 |
2006年 | 910篇 |
2005年 | 944篇 |
2004年 | 938篇 |
2003年 | 891篇 |
2002年 | 941篇 |
2001年 | 483篇 |
2000年 | 468篇 |
1999年 | 407篇 |
1998年 | 228篇 |
1997年 | 176篇 |
1996年 | 173篇 |
1995年 | 158篇 |
1994年 | 122篇 |
1993年 | 128篇 |
1992年 | 372篇 |
1991年 | 311篇 |
1990年 | 271篇 |
1989年 | 289篇 |
1988年 | 239篇 |
1987年 | 203篇 |
1986年 | 175篇 |
1985年 | 204篇 |
1984年 | 163篇 |
1983年 | 105篇 |
1982年 | 44篇 |
1979年 | 71篇 |
1977年 | 52篇 |
1974年 | 51篇 |
1973年 | 53篇 |
1971年 | 45篇 |
1969年 | 50篇 |
1968年 | 47篇 |
1966年 | 41篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Keiko Goto Yutaka Fujiwara Takeshi Isobe Naoko Chayahara Naomi Kiyota Toru Mukohara Yukari Tsubata Takamasa Hotta Kenji Tamura Noboru Yamamoto Hironobu Minami 《Cancer science》2019,110(6):1987-1994
Although dose reduction of S‐1 is recommended for patients with impaired renal function, dose modification for such patients has not been prospectively evaluated. The aim of the present study was to investigate the pharmacokinetic parameters of 5‐fluorouracil, 5‐chloro‐2,4 dihydroxypyridine and oteracil potassium, and to review the recommended dose modification of S‐1 in patients with renal impairment. We classified patients receiving S‐1 into 4 groups according to their renal function, as measured using the Japanese estimated glomerular filtration rate (eGFR) equation. The daily S‐1 dose was adjusted based on the patient's eGFR and body surface area. Blood samples were collected for pharmacokinetic analysis. A total of 33 patients were enrolled and classified into 4 groups as follows: 10 patients in cohort 1 (eGFR ≥ 80 mL/min/1.73 m2), 10 patients in cohort 2 (eGFR = 50‐79 mL/min/1.73 m2), 10 patients in cohort 3 (eGFR = 30‐49 mL/min/1.73 m2), and 3 patients in cohort 4 (eGFR < 30 mL/min/1.73 m2). Those in cohorts 3 and 4 treated with an adjusted dose of S‐1 showed a similar area under the curve for 5‐fluorouracil (941.9 ± 275.6 and 1043.5 ± 224.8 ng/mL, respectively) compared with cohort 2 (1034.9 ± 414.3 ng/mL). Notably, while there was a statistically significant difference between cohort 1 (689.6 ± 208.8 ng/mL) and 2 (P = 0.0474) treated with an equal dose of S‐1, there was no significant difference observed in the toxicity profiles of the cohorts. In conclusion, dose adjustment of S‐1 in patients with impaired renal function using eGFR is appropriate and safe. 相似文献
2.
Chie Teramoto PHN RN MS Satoko Nagata PhD PHN RN Reiko Okamoto PhD PHN RN Ruriko Suzuki PHN RN MS Emiko Kishi PhD PHN RN Michie Nomura DSN PHN RN Noriko Jojima PHN RN MS Masumi Nishida PhD PHN RN Keiko Koide PhD PHN RN Emiko Kusano PhD PHN RN Saori Iwamoto PhD PHN RN Sachiyo Murashima PhD PHN RN 《Public health nursing (Boston, Mass.)》2015,32(6):654-661
3.
4.
Setsuyo Morimoto Keiko Hirano Keiko Tabata Haruka Asaumi Yuko Morikawa Yuki Matsumi Shuhei Naka Michiyo Matsumoto-Nakano 《Pediatric Dental Journal》2019,29(3):138-145
Early onset periodontitis is rarely seen in infants, though often leads to an acute and serious clinical course when encountered in such patients. Autoimmune neutropenia presents systemic and dental symptoms, as depressed resistance to bacterial infection is caused by a disorder that reduces the number of neutrophils. This disease can result in not only gingival inflammation but also destruction of periodontal tissues, such as attachment loss, alveolar bone absorption, and early tooth loss in primary as well as mixed dentition. Here, we report treatment of a child with marginal periodontitis from the age of 3 years–7 years 9 months. No systemic manifestations were noted until 3 years of age, thus the patient had never received a detailed examination or medication related to the disease. Following examinations at our department, we referred the patient to a pediatrician at our university hospital for possible systemic disease, who made a diagnosis of autoimmune neutropenia. Although administration of antibiotics and professional dental care were continued, neutrophil count was not increased and progressive periodontal destruction was observed. Extraction of teeth with poor prognosis was performed and a prosthetic strategy for the missing teeth developed. It is important to recognize that periodontitis along with autoimmune neutropenia can appear in infants, even though the incidence is quite low. Early detection and early treatment of this disease is necessary for delaying progression of periodontitis and optimal occlusal induction of permanent teeth. 相似文献
5.
6.
7.
8.
9.
Toru Takahashi Yutaka Hasegawa Kiyohiro Ohshima Taro Nameki Yasuo Morishita 《Annals of thoracic and cardiovascular surgery》2005,11(4):245-248
Although aortic valve replacement (AVR) is an effective treatment for patients with aortic valvular disease, the implantation of a small aortic prosthesis may result in residual left ventricular outflow stenosis and transvalvular gradient. In this study, the outcome in the long-term period of patients treated with a small aortic prosthesis was analyzed retrospectively. Twenty-four patients with AVR were divided into two groups, group A and group B. Group A consisted of 16 patients with 21 mm-sized prosthetic valves, and group B consisted of 8 patients with 19 or 16 mm-sized prosthetic valves. There were no significant differences in preoperative cardiac function or operative procedure in the two groups. The mean follow-up period (months) was 55.0 in group A and 51.3 in group B. RESULTS: One patient died of cerebral infarction in group A. There were no significant differences in cardiothoracic ratio (CTR), left ventricular ejection fraction (LVEF), and left ventricular mass index (LVMI) between the two groups. Postoperative physical activity according to the New York Heart Association (NYHA) classification showed no significant differences in the two groups. Despite using a small prostheses for AVR, the postoperative course was good in the long-term period, although careful follow-up is necessary. 相似文献
10.
Y Wada H Hasegawa H Okuda K Yoshida N Yamaguchi 《The Japanese journal of psychiatry and neurology》1989,43(2):245-253
Kindling of the primary visual cortex (VC) was compared with that of the amygdala in cats. VC kindling was basically similar to kindling of the amygdala in that daily electrical stimulation can lead to the development of a generalized convulsion in most subjects, a growth of afterdischarges in their configuration and duration, and a reduction of the afterdischarge threshold. The kindling response of the VC differed from that of the amygdala in a number of respects, i.e., a high afterdischarge threshold, a different pattern of behavioral seizure development, an abrupt growth of electroclinical seizures coincident with the onset of a generalized convulsion, an intersubject variability in seizure susceptibility, and a marked seizure instability. In VC kindling the afterdischarge propagation into the amygdala was not observed until the generalized convulsion developed, and the early involvement of afterdischarge was seen in the pulvinar, lateral geniculate body, and superior colliculus. These data suggest that a neural mechanism different from amygdaloid kindling may participate in VC kindling, and that the subcortical structures of the visual system are involved in the preferential pathway for a seizure generalization from the VC. 相似文献