全文获取类型
收费全文 | 578篇 |
免费 | 24篇 |
国内免费 | 20篇 |
专业分类
儿科学 | 30篇 |
妇产科学 | 22篇 |
基础医学 | 34篇 |
口腔科学 | 10篇 |
临床医学 | 42篇 |
内科学 | 140篇 |
皮肤病学 | 11篇 |
神经病学 | 2篇 |
特种医学 | 101篇 |
外科学 | 77篇 |
综合类 | 8篇 |
预防医学 | 9篇 |
药学 | 105篇 |
中国医学 | 1篇 |
肿瘤学 | 30篇 |
出版年
2023年 | 5篇 |
2022年 | 4篇 |
2021年 | 11篇 |
2020年 | 8篇 |
2019年 | 7篇 |
2018年 | 13篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2015年 | 8篇 |
2014年 | 19篇 |
2013年 | 13篇 |
2012年 | 25篇 |
2011年 | 20篇 |
2010年 | 7篇 |
2009年 | 15篇 |
2008年 | 12篇 |
2007年 | 28篇 |
2006年 | 11篇 |
2005年 | 5篇 |
2004年 | 11篇 |
2003年 | 11篇 |
2002年 | 9篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 8篇 |
1998年 | 12篇 |
1997年 | 24篇 |
1996年 | 13篇 |
1995年 | 11篇 |
1994年 | 13篇 |
1993年 | 11篇 |
1992年 | 9篇 |
1991年 | 5篇 |
1990年 | 17篇 |
1989年 | 28篇 |
1988年 | 15篇 |
1987年 | 23篇 |
1986年 | 22篇 |
1985年 | 15篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 20篇 |
1981年 | 9篇 |
1980年 | 16篇 |
1979年 | 10篇 |
1978年 | 15篇 |
1977年 | 19篇 |
1976年 | 9篇 |
1975年 | 9篇 |
1974年 | 4篇 |
排序方式: 共有622条查询结果,搜索用时 31 毫秒
1.
K K Pihlajam?ki J H Kanto K M Oksman-Caldentey 《Acta pharmacologica et toxicologica》1986,59(4):259-262
A new method (ELISA) was used to evaluate the pharmacokinetics of scopolamine following intravenous (0.005 mg/kg), intramuscular (0.01 mg/kg), and oropharyngeal (0.035 mg/kg) administration of the drug to pregnant patients anaesthetized for caesarean section. After intravenous (N = 4) the drug fast disappeared from the circulation with a half-life of about 5 min., and the serum levels generally were measurable up to 3 hours, mean elimination half-life was 1.85 hours. A fast absorption was found after intramuscular injection, tmax = 10 min. (N = 4), and the drug had a clinically significant oropharyngeal absorption as well, tmax was around 1 hour (N = 6). The intramuscular and oropharyngeal, but not the intravenous, administrations produced a marked postoperative sedative and amnesic effects. All three administration ways caused a significant antisecretory action. 相似文献
2.
Cross-linking of Fc(gamma)-receptor on monocytes inhibits hepatitis C virus-specific cytotoxic T-lymphocyte induction in vitro. 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《Immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
T Kanto N Hayashi T Takehara K Katayama A Ito K Mochizuki N Kuzushita T Tatsumi Y Sasaki A Kasahara M Hori 《Immunology》1998,94(4):461-468
In hepatitis C virus (HCV) infection, immune complex (IC)-type virus particles are frequently observed in circulation. The IC leads to cross-linking of Fcgamma receptors (FcgammaR) on monocytes and exerts immunoinhibitory function. To test the roles of IC in HCV-specific cytotoxic T lymphocyte (CTL) induction, we generated HCV CTL from peripheral blood mononuclear cells of chronic hepatitis C patients with or without HCV-IC- or immunoglobulin G (IgG)-coated culture plates and compared their lytic activities. HCV-IC or adherent IgG, which induces FcgammaR cross-linking, significantly reduced CTL activity. Expression of B7-1 on monocytes decreased on adherent IgG. In addition, tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) production increased from cells on adherent IgG and their mRNA expression in monocytes was enhanced. Anti-TNF-alpha antibody during induction on adherent IgG inhibited lysis; however, anti-TGF-beta completely reversed its inhibitory effect. These results demonstrated that HCV-IC or adherent IgG impaired HCV-CTL induction in vitro. The FcgammaR-mediated CTL suppression occurred via decreased expression of monocyte B7-1 and/or enhanced production of TGF-beta1. 相似文献
3.
Pseudotype hepatitis C virus enters immature myeloid dendritic cells through the interaction with lectin 总被引:3,自引:0,他引:3
Kaimori A Kanto T Kwang Limn C Komoda Y Oki C Inoue M Miyatake H Itose I Sakakibara M Yakushijin T Takehara T Matsuura Y Hayashi N 《Virology》2004,324(1):74-83
Dendritic cells (DC) are the most potent antigen-presenting cells that regulate immune responses. One of the mechanisms for hepatitis C virus (HCV) persistence is the ability of HCV to suppress DC function. Direct HCV infection to blood DC has been implicated for DC dysfunction. To clarify the susceptibility of each DC subset to HCV, we used pseudotype vesicular stomatitis virus (VSV) coated with chimeric HCV envelope glycoproteins (E1 and E2). We demonstrate that pseudotype VSV enters myeloid DC (MDC) but not plasmacytoid DC (PDC). The highest efficiency of pseudotype VSV entry to MDC was observed when MDC were cultured with GM-CSF. Such efficiency decreased when MDC are matured with the treatment of IL-4, CpG oligodeoxynucleotide, or CD40 ligand. Mannan inhibited pseudotype VSV entry to MDC, but Ca(2+) chelators failed to do so. These results show that pseudotype VSV possessing HCV-E1 and E2 enters immature MDC through the interaction with lectins in a Ca(2+)-independent manner. 相似文献
4.
5.
6.
7.
Tahata Yuki Hikita Hayato Mochida Satoshi Enomoto Nobuyuki Kawada Norifumi Kurosaki Masayuki Ido Akio Miki Daiki Yoshiji Hitoshi Takikawa Yasuhiro Sakamori Ryotaro Hiasa Yoichi Nakao Kazuhiko Kato Naoya Ueno Yoshiyuki Yatsuhashi Hiroshi Itoh Yoshito Tateishi Ryosuke Suda Goki Takami Taro Nakamoto Yasunari Asahina Yasuhiro Matsuura Kentaro Yamashita Taro Kanto Tatsuya Akuta Norio Terai Shuji Shimizu Masahito Sobue Satoshi Miyaki Tomokatsu Moriuchi Akihiro Yamada Ryoko Kodama Takahiro Tatsumi Tomohide Yamada Tomomi Takehara Tetsuo 《Journal of gastroenterology》2022,57(2):120-132
Journal of Gastroenterology - Direct-acting antiviral (DAA) therapy enables a high rate of sustained virologic response (SVR) in patients with hepatitis C virus associated cirrhosis. However, the... 相似文献
8.
9.
Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice 总被引:3,自引:3,他引:3
Ulich TR; del Castillo J; Senaldi G; Kinstler O; Yin S; Kaufman S; Tarpley J; Choi E; Kirley T; Hunt P; Sheridan WP 《Blood》1996,87(12):5006-5015
PEG-rHuMGDF injected daily in normal mice causes a rapid dose-dependent increase in megakaryocytes and platelets. At the same time that platelet numbers are increased, the mean platelet volume (MPV) and platelet distribution width (PDW) can be either decreased, normal, or increased depending on the dose and time after administration. Thus, PEG-rHuMGDF at a low dose causes decreases in MPV and PDW, MGDF at an intermediate dose causes an initial increase followed by a decrease in MPV and PDW, and PEG-rHuMGDF at higher doses causes an increase in MPV and PDW followed by a gradual normalization of these platelet indices. In addition to the expected thrombocytosis after 7 to 10 days of daily injection of high doses of PEG-rHuMGDF, a transient decrease in peripheral red blood cell numbers and hemoglobin is noted accompanied in the bone marrow by megakaryocytic hyperplasia, myeloid hyperplasia, erythroid and lymphoid hypoplasia, and deposition of a fine network of reticulin fibers. Splenomegaly, an increase in splenic megakaryocytes, and extramedullary hematopoiesis accompany the hematologic changes in the peripheral blood and marrow to complete a spectrum of pathologic features similar to those reported in patients with myelofibrosis and megakaryocyte hyperplasia. However, all the PEG-rHuMGDF-initiated hematopathology including the increase in marrow reticulin is completely and rapidly reversible upon the cessation of administration of PEG-rHuMGDF. Thus, transient hyperplastic proliferation of megakaryocytes does not cause irreversible tissue injury. Furthermore, PEG-rHuMGDF completely ameliorates carboplatin-induced thrombocytopenia at a low-dose that does not cause the hematopathology associated with myelofibrosis. 相似文献
10.
Oze T Hiramatsu N Song C Yakushijin T Iio S Doi Y Oshita M Hagiwara H Mita E Ito T Inui Y Hijioka T Tamura S Yoshihara H Inoue A Imai Y Hayashi E Kato M Miyazaki M Hosui A Miyagi T Yoshida Y Tatsumi T Kiso S Kanto T Kasahara A Hayashi N Takehara T 《Journal of gastroenterology》2012,47(3):334-342