全文获取类型
收费全文 | 396篇 |
免费 | 20篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 57篇 |
妇产科学 | 59篇 |
基础医学 | 48篇 |
口腔科学 | 2篇 |
临床医学 | 14篇 |
内科学 | 77篇 |
皮肤病学 | 4篇 |
神经病学 | 49篇 |
特种医学 | 45篇 |
外科学 | 22篇 |
综合类 | 1篇 |
预防医学 | 13篇 |
眼科学 | 2篇 |
药学 | 18篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 9篇 |
2020年 | 9篇 |
2019年 | 7篇 |
2018年 | 6篇 |
2017年 | 16篇 |
2016年 | 10篇 |
2015年 | 8篇 |
2014年 | 22篇 |
2013年 | 29篇 |
2012年 | 18篇 |
2011年 | 23篇 |
2010年 | 11篇 |
2009年 | 15篇 |
2008年 | 22篇 |
2007年 | 12篇 |
2006年 | 24篇 |
2005年 | 24篇 |
2004年 | 22篇 |
2003年 | 17篇 |
2002年 | 9篇 |
2001年 | 15篇 |
2000年 | 11篇 |
1999年 | 16篇 |
1998年 | 6篇 |
1997年 | 8篇 |
1996年 | 6篇 |
1995年 | 3篇 |
1994年 | 7篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1969年 | 1篇 |
1938年 | 1篇 |
排序方式: 共有416条查询结果,搜索用时 15 毫秒
1.
Monatsschrift Kinderheilkunde - Fusionen und Übernahmen in der Pharmaindustrie haben zu einer Konzentration geführt, von der auch die Impfstoffproduktion mit nur noch wenigen global... 相似文献
2.
J. Kassubek A.-D. Sperfeld A. Baumgartner H.-J. Huppertz A. Riecker F. D. Juengling 《European journal of neurology》2006,13(8):880-886
Hereditary spastic paraparesis (HSP) is a heterogeneous group of neurodegenerative disorders with progressive lower limb spasticity, categorized into pure (p-HSP) and complicated forms (c-HSP). The purpose of this study was to evaluate if brain volumes in HSP were altered compared with a control population. Brain volumes were determined in patients suffering from HSP, including both p-HSP ( n = 21) and c-HSP type ( n = 12), and 30 age-matched healthy controls, using brain parenchymal fractions (BPF) calculated from 3D MRI data in an observer-independent procedure. In addition, the tissue segments of grey and white matter were analysed separately. In HSP patients, BPF were significantly reduced compared with controls both for the whole patient group ( P < 0.001) and for both subgroups, indicating considerable brain atrophy. In contrast to controls who showed a decline of brain volumes with age, this physiological phenomenon was less pronounced in HSP. Therefore, global brain parenchyma reduction, involving both grey and white matter, seems to be a feature in both subtypes of HSP. Atrophy was more pronounced in c-HSP, consistent with the more severe phenotype including extramotor involvement. Thus, global brain atrophy, detected by MRI-based brain volume quantification, is a biological marker in HSP subtypes. 相似文献
3.
4.
5.
6.
7.
8.
Bettina Pascher Judith Kröll Ian Mothersill Günter Krämer Hans‐Jürgen Huppertz 《Epilepsia》2013,54(2):305-313
Purpose: To describe a novel magnetic resonance imaging (MRI) postprocessing technique for the detection of periventricular nodular heterotopia (PNH) and to evaluate its diagnostic value. The method is a further development of voxel‐based morphometric analysis with focus on a region of interest around the lateral ventricles to increase the sensitivity and specificity for automated detection of abnormally located gray matter in this area. Methods: T1‐weighted MRI volume data sets were normalized and segmented in statistical parametric mapping (SPM 5 software), and the distribution of gray matter was compared to a normal database. As a new approach, individual masks derived from segmentation of the lateral ventricles were used to restrict the search for ectopic gray matter to the periventricular area. PNH were automatically detected by localizing the maximum deviation from the normal database in this area, provided that the z‐score exceeded a certain threshold. The optimal z‐score threshold for maximum sensitivity and specificity was determined by a receiver operating characteristic (ROC) curve analysis. The method was applied in 40 patients with PNH and 400 controls. Key Findings: PNH were detected in 37 of 40 patients, and false positives were found in 34 of 400 controls, amounting to 92.5% sensitivity and 91.5% specificity. In 17 of the patients in whom PNH could be identified, these lesions had been overlooked in the past, and in 8 patients even in the high‐resolution MRI subsequently used for postprocessing. Significance: The results suggest that automated morphometric MRI analysis with focus on ectopic gray matter in the periventricular areas facilitates the evaluation of MRI data and increases the sensitivity for the detection of PNH. 相似文献
9.
C. Karsten S. Baumgarte A. W. Friedrich C. von Eiff K. Becker W. Wosniok A. Ammon J. Bockemühl H. Karch H.-I. Huppertz 《European journal of clinical microbiology & infectious diseases》2009,28(8):935-943
In developed countries, acute gastroenteritis (AGE) is a major source of morbidity. However, only a few studies have estimated
its incidence and the associated medical burden. This population-based study determined the incidence of community-acquired
AGE patients seeking medical care and the relative role of various pathogens. Stool samples from patients with AGE presenting
to a general practitioner (GP), pediatrician, or specialist in internal medicine for that reason were screened for various
bacterial and viral enteropathogens. A control group was established as well. Incidences were calculated by the number of
positive patients divided by the general population. The study was performed in north-west Germany in 2004. The incidence
of AGE patients requiring medical consultation was 4,020/100,000 inhabitants. Children (<5 years of age) were at the highest
risk (13,810/100,000 inhabitants). Of the patients, 6.6% were tested positive for an enteropathogenic bacteria and 17.7% for
a viral agent. The predominant pathogens were norovirus (626/100,000) and rotavirus (270/100,000). Salmonella was the most frequently detected bacteria (162/100,000). The results presented confirm AGE and, specifically, AGE of viral
origin as a major public health burden in developed countries. 相似文献
10.