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排序方式: 共有104条查询结果,搜索用时 218 毫秒
1.
KOHICHI ASAMI HIDENOBU ASHIKAWA TOMOKO TERAI NAOKO ISHIHARA HIROKO NAWATA KENZO HIRAO NOBUYUKI MIYASAKA TOKUHIRO KAWARA KAZUMASA HIEJIMA TOMOO HARADA FUMIO SUZUKI 《Pacing and clinical electrophysiology : PACE》1998,21(2):352-366
The typical fourth criterion for transient entrainment is defined when both a sudden shortening in conduction interval to and a distinct change in electrogram morphology at a bipolar recording site are demonstrated while performing overdrive pacing of a reentrant tachycardia from a single pacing site at two different constant rates. The purpose of this article was to test the hypothesis that if an intracardiac recording site showing both orthodromic and antidromic capture with entrainment pacing is located suitably distant from the circuit, sudden shortening in conduction interval to that site may occur without any significant change in the bipolar electrogram morphology (i.e., atypical form of the fourth criterion). Atrial overdrive pacing of orthodromic tachycardia was performed in 20 patients with either left anterior (12 patients) or left posterior (8 patients) accessory pathways. We investigated the effects of overdrive pacing from the proximal or distal coronary sinus, specifically effects on the electrogram interval and the electrogram morphology at the right atrial appendage. Overdrive pacing of orthodromic tachycardia from the proximal coronary sinus was performed in 10 of the 12 patients with left anterior accessory pathways; those 10 patients demonstrated the first entrainment criterion at the right atrial appendage site. Overdrive pacing of orthodromic tachycardia at still shorter cycle lengths demonstrated a sudden shortening in conduction interval to the right atrial appendage site. Despite shortening in conduction interval the morphology of the right atrial appendage electrogram was completely or almost identical to that during orthodromic tachycardia, indicating an atypical form of the fourth criterion. This criterion was not demonstrated in patients with left posterior accessory pathways. Thus, atypical fourth entrainment criterion was demonstrated during overdrive pacing of orthodromic tachycardia from the proximal coronary sinus only in patients with left anterior accessory path ways. Demonstration of atypical fourth criterion seems largely dependent on the location of the accessory pathway, the pacing, and the recording sites. 相似文献
2.
HIROKO NEBIKI TETSUO ARAKAWA KAZUHIDE HIGUCHI KENZO KOBAYASHI 《Journal of gastroenterology and hepatology》1997,12(2):109-114
The usefulness of dye-contrast endoscopy for the evaluation of the quality of gastric ulcer healing and the prediction of relapse was investigated. Sixty consenting patients whose ulcers healed during 3 months of treatment underwent endoscopy for the identification of the pattern of mucosal regeneration. Patients were monitored for relapses for up to 18 months after antiulcer therapy had ended. The pattern of regeneration was flat in 24 patients, nodular in 25 and intermediate in 11. Internal hypoechoic areas seen by endoscopic ultrasonography were less common and histological maturity was better in the patient group with the flat pattern compared with the patient group with the nodular pattern of mucosal regeneration. Prostaglandin E, synthesis was highest in the group with the flat pattern of mucosal regeneration and the relapse rate was lowest in this group. We conclude that the evaluation of the quality of ulcer healing is possible and that findings in individuals may aid the prediction of relapse for particular patients. 相似文献
3.
CHERRIE A. MAHI-BROWN RYUZO YANAGIMACHI MARITA L. NELSON HIROKO YANAGIMACHI NICOLAS PALUMBO 《American journal of reproductive immunology (New York, N.Y. : 1989)》1988,18(3):94-103
ABSTRACT: The ovarian histopathology of bitches immunized with crude (cPZP) or partially purified (pPZP) porcine zona pellucida proteins was examined in order to determine the cause of abnormal estrous cycles. The majority of immunized bitches had ovarian cytes. Those immunized with cPZP had follicular cysts lined with a thin layer of granulosa cells, while in those immunized with pPZP, the cysts were lined by a basement membrane with a clump of luteinized cells. In two bitches immunized with cPZP, oocytes were present only in primordial follicles. Similar abnormalities were not found in a bitch immunized with human serum albumin or in 12 untreated bitches. Oocytes flushed from the oviducts of mated, immunized bitches were degenerating, which may have been a primary cause of infertility in such bitches. Ovaries studied 2–6 weeks after immunization showed no loss of gap junctional communication between oocytes and granulosa cells, nor was any inflammatory reaction seen. IgG was bound to the zona as revealed by fluoresceinated protein A staining of frozen sections of those ovaries. Abnormal estrous cycles in PZP-immunized bitches appear to result from follicular dysgenesis or cyst formation, but the etiology of these conditions is unresolved. 相似文献
4.
A case of small cell carcinoma of the gall-bladder Is described. lmmunohistochemically, the tumor cells were positive for chromogranin A, synaptophysin and neuronspecific enolase, which suggests that they derived from neuroendocrine cells. The overlying and surroundlng epithelium of the tumor showed intestinal metaplasia including goblet cells, pseudopyloric glands, Paneth's cells, and chromogranin A and synaptophysin-positive endocrine cells. Definite adenocarcinoma was absent. The endocrine cells in the epithellum were more numerous In the vicinity of the tumor. The present case supports the supposition that endocrine cell tumor (including small cell carcinoma) of the gall-bladder may develop from endocrine cells of the intestinal metaplastic lesion. 相似文献
5.
Effect of rectal administration of rebamipide on dextran sulfate sodium-induced colitis: Role of hepatocyte growth factor 总被引:1,自引:0,他引:1
R. Murai T. Kanbe T. Mukoyama T. Shimomura K. Hashiguchi Y. Yoshida H. Tsuchiya Y. Hoshikawa A. Kurimasa G. Shiota 《Inflammation research》2007,56(6):240-245
Objective and design: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth
factor (HGF) in the action of rebamipide.
Materials: Fifty-five and forty female Balb/c mice, respectively, were used in Exp. 1 and 2.
Treatment: 50 mg/kg/day rebamipide (Exp. 1) and 1 × 107 pfu pAxCAHGF (the CAG promoter-driving HGF gene in adenovirus vector) (Exp. 2) were intrarectally introduced after induction
of colitis by 4 % dextran sulfate sodium (DSS).
Methods: Therapeutic effects were assessed by cell proliferation and apoptosis.
Results: Rebamipide caused proliferation of epithelial cells at 10 days after treatment, and decreased apoptosis at 10, 14 and 21 days,
compared with controls. Expression of HGF was greatly increased in rebamipide-treated mice. pAxCAHGF caused cell proliferation
and apoptosis, which showed the same pattern as with rebamipide treatment.
Conclusions: Rectal administration of rebamipide is effective for DSS-induced colitis in association with induction of HGF.
Received 17 June 2006; returned for revision 23 August 2006; returned for final revision 29 October 2006; accepted by I. Ahnfelt-R?nne
14 December 2006 相似文献
6.
7.
The recent emergence of stem cell-based tissue engineering has now opened up new venues for gene therapy. The task now is
to develop safe and effective vectors that can deliver therapeutic genes into specific stem cell lines and maintain long-term
regulated expression of these genes. Human artificial chromosomes (HACs) possess several characteristics that require gene
therapy vectors, including a stable episomal maintenance, and the capacity for large gene inserts. HACs can also carry genomic
loci with regulatory elements, thus allowing for the expression of transgenes in a genetic environment similar to the chromosome.
Currently, HACs are constructed by a two prone approaches. Using a top-down strategy, HACs can be generated from fragmenting
endogenous chromosomes. By a bottom-up strategy, HACs can be created de novo from cloned chromosomal components using chromosome engineering. This review describes the current advances in developing
HACs, with the main focus on their applications and potential value in gene delivery, such as HAC-mediated gene expression
in embryonic, adult stem cells, and transgenic animals. 相似文献
8.
SATORU SAKUMA YOHKO FUJIMOTO SHINYA TAGANO MASAHIDE TSUNOMORI HIROKO NISHIDA TADASHI FUJITA 《The Journal of pharmacy and pharmacology》1997,49(2):150-153
The effects of nonanal, trans-2-nonenal and 4-hydroxy-2,3-trans-nonenal on the formation of thromboxane B2 (TXB2), 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) from exogenous arachidonic acid in washed rabbit platelets were examined. Nonanal and trans-2-nonenal at concentrations ranging from 0.25 to 2 μm inhibited TXB2, HHT and 12-HETE formation, reducing the amounts of these three arachidonic acid metabolites by 50% at nonanal and trans-2-nonenal concentrations of approximately 0.25 μm. The inhibition of TXB2, HHT and 12-HETE formation induced by 4-hydroxy-2,3-trans-nonenal (50% inhibition by 4-hydroxy-2,3-trans-nonenal at a concentration of approximately 100 μm) was 400 times weaker than that induced by nonanal and trans-2-nonenal. These results suggest that nonanal and trans-2-nonenal can be modulators of platelet arachidonic acid metabolism by affecting the activity of cyclooxygenase and 12-lipoxygenase. 相似文献
9.
HIROKO TSUKAMOTO HIDEOKI FUKUOKA MIEKO KOYASU YASUSHI NAGAI HIDEMI TAKIMOTO 《Pediatrics international》2007,49(6):985-990
BACKGROUND: The purpose of the paper was to determine the risk factors for small-for-gestational-age (SGA) infants at full term, in Japan. METHODS: The study was conducted at four hospitals and clinics in the Tokyo metropolitan area. A retrospective review of 2972 mothers and their infants born from singleton pregnancies at any time during the years 2002 and 2003 was conducted. RESULTS: Of these women, 8.4% gave birth to SGA infants. The proportion of SGA infants was significantly higher among heavy smokers (>10 cigarettes/day; 13.7%, P < 0.01). The odds ratio (OR) for SGA decreased significantly in proportion to the pregnancy body mass index (OR, 0.89; 95% confidence interval [CI]: 0.84-0.94, P < 0.001). The OR of SGA for stratified maternal weight gain was 1.79 (95%CI: 1.24-2.58, P = 0.01) for weight gain < 8.0 kg; 1.16 (95%CI: 0.79-1.71, P = 0.45) for weight gain 8.0-10.0 kg; and 0.49 (95%CI: 0.3-0.78, P < 0.01) for weight gain >12 kg. CONCLUSION: The present study clearly confirms the detrimental effect of a low prepregnancy body mass index, low maternal weight gain and maternal smoking during pregnancy on the incidence of SGA infants. 相似文献