全文获取类型
收费全文 | 1588篇 |
免费 | 93篇 |
国内免费 | 81篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 69篇 |
妇产科学 | 33篇 |
基础医学 | 179篇 |
口腔科学 | 26篇 |
临床医学 | 263篇 |
内科学 | 389篇 |
皮肤病学 | 40篇 |
神经病学 | 58篇 |
特种医学 | 302篇 |
外科学 | 94篇 |
综合类 | 36篇 |
一般理论 | 1篇 |
预防医学 | 55篇 |
眼科学 | 9篇 |
药学 | 83篇 |
肿瘤学 | 121篇 |
出版年
2023年 | 2篇 |
2022年 | 8篇 |
2021年 | 14篇 |
2019年 | 13篇 |
2018年 | 9篇 |
2017年 | 14篇 |
2016年 | 14篇 |
2015年 | 22篇 |
2014年 | 16篇 |
2013年 | 41篇 |
2012年 | 30篇 |
2011年 | 36篇 |
2010年 | 56篇 |
2009年 | 55篇 |
2008年 | 44篇 |
2007年 | 74篇 |
2006年 | 30篇 |
2005年 | 42篇 |
2004年 | 29篇 |
2003年 | 21篇 |
2002年 | 32篇 |
2001年 | 23篇 |
2000年 | 31篇 |
1999年 | 31篇 |
1998年 | 97篇 |
1997年 | 93篇 |
1996年 | 118篇 |
1995年 | 91篇 |
1994年 | 91篇 |
1993年 | 80篇 |
1992年 | 37篇 |
1991年 | 44篇 |
1990年 | 38篇 |
1989年 | 57篇 |
1988年 | 45篇 |
1987年 | 33篇 |
1986年 | 44篇 |
1985年 | 35篇 |
1984年 | 16篇 |
1983年 | 23篇 |
1982年 | 23篇 |
1981年 | 21篇 |
1980年 | 19篇 |
1979年 | 7篇 |
1978年 | 10篇 |
1977年 | 14篇 |
1976年 | 14篇 |
1975年 | 8篇 |
1974年 | 4篇 |
1969年 | 5篇 |
排序方式: 共有1762条查询结果,搜索用时 15 毫秒
1.
2.
3.
Costs and benefits of routine follow-up after curative treatment for endometrial cancer 总被引:6,自引:0,他引:6
下载免费PDF全文
![点击此处可从《Canadian Medical Association journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
OBJECTIVE: To examine the costs of routine outpatient follow-up after curative treatment of endometrial cancer, and to determine whether this leads to early detection of recurrence or survival. The impact of specific disease characteristics on survival is examined. DESIGN: Retrospective chart review, and calculation of costs. SETTING: Ottawa Regional Cancer Centre-Civic Division (ORCC-C). PATIENTS: All 432 patients referred to the ORCC-C with endometrial cancer between 1982 and 1991 who received treatment with curative intent and who continued with routine follow-up. RESULTS: Cancer recurred in 50 patients (11.57%). There was no statistically significant difference in overall survival between patients with symptomatic and asymptomatic recurrences, or between those with recurrences detected during routine follow-up visits or in the interval between routine visits. Of 4830 Papanicolaou (Pap) smears performed routinely, cancer was detected in 6 cases. The mean cost of the routine follow-up procedures for each patient with a recurrence was $19,200. CONCLUSION: Intensive follow-up of women with endometrial cancer does not result in improved survival. A prospective randomized study is warranted to evaluate other potential benefits of follow-up, such as improved quality of life or decreased morbidity. There is no economic or clinical justification for the routine use of the Pap smear in the follow-up of patients with endometrial cancer. The potential benefits of routine follow-up in endometrial cancer and other types of cancer with favourable prognoses warrant critical evaluation. 相似文献
4.
E Grunfeld R Glossop I McDowell C Danbrook 《Canadian Medical Association journal》1997,157(8):1101-1105
The emphasis on home-based care is one important aspect of health services restructuring initiatives in Canada. Fundamental to the preference for home-based care over institutional care is the expectation that family caregivers will be available in the home to support patients who would otherwise be in an institution. The authors explore the potential impact of this devolution of services from institutions to the home in 2 vulnerable patient populations--elderly patients with dementia and elderly patients with terminal illnesses. Community-based surveillance strategies are needed to determine the true health, quality-of-life and economic outcomes of these restructuring initiatives. 相似文献
5.
6.
7.
8.
9.
Y Leskinen JP Salenius T Lehtim?ki H Huhtala H Saha 《American journal of kidney diseases》2002,40(3):472-479
BACKGROUND: Knowledge of the prevalence of peripheral arterial disease (PAD) in patients with chronic renal failure (CRF) is limited because of a lack of uniformity in disease definition and recognition. Furthermore, little is known of the prevalence of medial arterial calcification (MAC) in patients with CRF. Our goal is to study the prevalence of PAD and MAC defined by ankle brachial index (ABI) or toe brachial index (TBI) measurements in a Finnish population of patients with CRF consisting of predialysis and dialysis patients, as well as renal transplant recipients. METHODS: We examined 136 patients with CRF and 59 control subjects. Fifty-nine of the patients with CRF had moderate to severe predialysis CRF, 36 patients were on dialysis treatment, and 41 were renal transplant recipients. Mean age of patients was 51.9 +/- 11.5 years, and 39 patients (29%) had diabetes. ABI and TBI were measured by means of photoplethysmography. The definition of PAD required an ABI value of 0.90 or less, a TBI value of 0.60 or less, or a previous positive lower-extremity angiogram result. ABI values of 1.3 or greater or incompressible arteries at ankle level indicated MAC. The presence of claudication was determined by an interview. RESULTS: Prevalences of PAD on this study were 22.0% in patients with predialysis CRF, 30.6% in patients on dialysis treatment, 14.6% in renal transplant recipients, and 1.7% in the control group (P = 0.001). Prevalences of MAC were 23.7%, 41.7%, 23.1%, and 3.4% (P < 0.001), respectively. Only 9 patients had claudication, and 6 of those patients had PAD. CONCLUSION: Both asymptomatic PAD and MAC are common in patients with CRF. Therefore, we recommend the use of both ABI and TBI measurements in the evaluation of PAD in patients with CRF. 相似文献
10.
R Joseph C Tsering S Grunfeld K M Welch 《Stroke; a journal of cerebral circulation》1991,22(11):1448-1451
BACKGROUND: We do not fully understand the mechanisms for neuronal damage following cerebral arterial occlusion by a thrombus that consists mainly of platelets. The view that certain endogenous substances, such as glutamate, may also contribute to neuronal injury is now reasonably well established. Blood platelets are known to contain and secrete a number of substances that have been associated with neuronal dysfunction. Therefore, we hypothesize that a high concentration (approximately several thousand-fold higher than in plasma, in our estimation) of locally released platelet secretory products derived from the causative thrombus may contribute to neuronal injury and promote reactive gliosis. SUMMARY OF COMMENT: We have recently been able to report some direct support for this concept. When organotypic spinal cord cultures were exposed to platelet and platelet products, a significant reduction in the number and the size of the surviving neurons occurred in comparison with those in controls. We further observed that serotonin, a major platelet product, has neurotoxic properties. There may be other platelet components with similar effect. CONCLUSIONS: The hypothesis of platelet-mediated neurotoxicity gains some support from these recent in vitro findings. The concept could provide a new area of research in stroke, both at the clinical and basic levels. 相似文献