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Current management of ALS: comparison of the ALS CARE Database and the AAN Practice Parameter. The American Academy of Neurology 总被引:1,自引:0,他引:1
Bradley WG Anderson F Bromberg M Gutmann L Harati Y Ross M Miller RG;ALS CARE Study Group 《Neurology》2001,57(3):500-504
BACKGROUND: The American Academy of Neurology (AAN) ALS Practice Parameter was published in April 1999. The ALS CARE Database has been collecting data on the management of patients with ALS in North America since 1996. OBJECTIVE: To compare the management of patients with ALS in North America as recorded in the ALS CARE Database with the recommendations of the AAN ALS Practice Parameter. METHODS: Data were analyzed from 2018 patients at enrollment and from 373 of these patients who died between enrollment and May 1999. RESULTS: Eighty-two percent of the enrolled patients reported that they had been given enough information about ALS. Only 54% of patients with drooling were receiving medication for this problem. Only 41% of those who reported being depressed most of the time were receiving antidepressant medications. Only 28% of those with dyspnea and only 9.2% of those with a forced vital capacity <40% predicted were receiving noninvasive positive pressure ventilator support. Only 30% of those with moderate to severe dysphagia had a gastrostomy tube. Half of the patients who died did so at home, but only 47% of them received residential hospice services. Although 89% of patients who died were recorded as having done so peacefully, 17% were reported to have had breathing difficulties (i.e., respiratory distress), 8% anxiety, 3.3% pain, and 2.5% choking. Advance directives were in place for 90% of the patients who died, and in 97% of cases these directives were followed. CONCLUSIONS: These findings indicate that in the 3-year period prior to the publication of the AAN Practice Parameter, many but not all patients received the care that is recommended in that parameter; there were deficiencies, particularly in the key areas of gastrostomy and noninvasive positive pressure ventilation. 相似文献
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Zeiger RS Mauger D Bacharier LB Guilbert TW Martinez FD Lemanske RF Strunk RC Covar R Szefler SJ Boehmer S Jackson DJ Sorkness CA Gern JE Kelly HW Friedman NJ Mellon MH Schatz M Morgan WJ Chinchilli VM Raissy HH Bade E Malka-Rais J Beigelman A Taussig LM;CARE Network of the National Heart Lung Blood Institute 《The New England journal of medicine》2011,365(21):1990-2001
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T. L. CLEMENS G. N. HENDY S. E. PAPAPOULOS L. J. FRAHER A. D. CARE J. L. H. O''RIORDAN 《Clinical endocrinology》1979,11(2):225-234
1 alpha, 25-Dihydroxycholecalciferol (1,25-(OH)2D3) has been measured in human serum by radioimmunoassay. The assay uses a high titre antiserum raised in sheep against 1,25-(OH)2D3-25-hemisuccinate, conjugated to bovine serum albumin. The sensitivity of the assay is 10 pg/tube. Other hydroxylated forms of vitamin D3 cross react with the antiserum and are therefore removed from serum extracts by chromatography on Sephadex LH 20 followed by high pressure liquid chromatography. The mean (+/- SEM) serum 1,25-(OH)2D3 concentration for a group of healthy adult subjects was 41 +/- 2.5 pg/ml. None was detected in anephric patients and the concentration was low or undetectable in patients with chronic renal failure. 相似文献
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Alan Lam MBBS FRACOG FRCOG Associate Professor Yuval Kaufman BSc MD Fellow at CARE Su Yen Khong MBChB MRCOG Fellow at CARE Andy Liew MBBS BSc FANZCA Stephen Ford MBBS BSc FANZCA VMO Anaesthetist George Condous MRCOG FRANZCOG Associate Professor 《Best practice & research. Clinical obstetrics & gynaecology》2009,23(5):631-646