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Sex chromosome trisomies (SCT) are among the most common chromosomal duplications in humans. Due to recent technological advances in non-invasive screening, SCT can already be detected during pregnancy. This calls for more knowledge about the development of (young) children with SCT. This review focused on neurocognitive functioning of children with SCT between 0 and 18 years, on domains of global intellectual functioning, language, executive functioning, and social cognition, in order to identify targets that could benefit from early treatment. Online databases were used to identify peer-reviewed scientific articles using specific search terms. In total 18 studies were included. When applicable, effect sizes were calculated to indicate clinical significance. Results of the reviewed studies show that although traditionally, the focus has been on language and intelligence (IQ) in this population, recent studies suggest that executive functioning and social cognition may also be significantly affected already in childhood. These findings suggest that neuropsychological screening of children diagnosed with SCT should be extended, to also include executive functioning and social cognition. Knowledge about these neurocognitive risks is important to improve clinical care and help identify targets for early support and intervention programs to accommodate for the needs of individuals with SCT. 相似文献
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Joosen Margot C. W. Lugtenberg Marjolein Arends Iris van Gestel Hanneke J. A. W. M. Schaapveld Benedikte Terluin Berend van Weeghel Jaap van der Klink Jac J. L. Brouwers Evelien P. M. 《Journal of occupational rehabilitation》2022,32(2):272-283
Journal of Occupational Rehabilitation - Purpose Although common mental disorders (CMDs) highly impact individuals and society, a knowledge gap exists on how sickness absence can be prevented in... 相似文献
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The health care industry, in particular the hospital industry, is under an increasing degree of pressure, by an ageing population, advancing expensive medical technology a shrinking labor. The pressure on hospitals is further increased by the planned budget cuts in public spending by many current administrations as a result of the economic and financial crises. However, productivity increases may alleviate these problems. Therefore we study whether productivity in the hospital sector is growing, and whether this productivity growth can be influenced by government policy. Using an econometric time series analysis of the hospital sector in the Netherlands, productivity is estimated for the period 1972–2010. Then, productivity is linked to the different regulation regimes during that period, ranging from output funding in the 1970s to the current liberalized hospital market. The results indicate that the average productivity of the hospital sector in different periods differs and that these differences are related to the structure of regulation in those periods. 相似文献
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Evelien Meulenijzer Krishna Vyncke Idoia Labayen Aline Meirhaeghe Laurent Béghin Christina Breidenassel Vanesa España-Romero Υannis Manios Marika Ferrari Luis A. Moreno Frédéric Gottrand Stefaan De Henauw Marcela González-Gross Anthony Kafatos Kurt Widhalm Dénes Molnár Michael Sjöstrom Ascensión Marcos Odysseas Androutsos Julia Wärnberg Chantal C. Gilbert Inge Huybrechts 《European journal of pediatrics》2015,174(2):271-278
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Lorenzo Fuccio Douglas Rex Thierry Ponchon Leonardo Frazzoni Mário Dinis-Ribeiro Pradeep Bhandari Evelien Dekker Maria Pellisè Loredana Correale Jeanin van Hooft Rodrigo Jover Diogo Libanio Franco Radaelli Sergio Alfieri Franco Bazzoli Carlo Senore Jaroslaw Regula Thomas Seufferlein Cesare Hassan 《Gastroenterology》2019,156(5):1309-1323.e3
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Evelien Platje Lucres M.C. Jansen Adrian Raine Susan J.T. Branje Theo A.H. Doreleijers Marjan de Vries-Bouw Arne Popma Pol A.C. van Lier Hans M. Koot Wim H.J. Meeus Robert R.J.M. Vermeiren 《Biological psychology》2013
Although several studies have associated antisocial behavior with decreased cortisol awakening responses (CAR), studies in adolescent samples yielded inconsistent results. In adolescence however, the CAR develops and antisocial behavior is heterogeneous in type and persistence. Therefore this longitudinal study compared persistent aggressive and rule-breaking adolescents to low aggressive and rule-breaking adolescents on the development of the CAR from ages 15 to 17 (N = 390). Persistently high aggressive adolescents showed decreased cortisol levels at awakening consistently over the years (Δχ2(1) = 6.655, p = .01) as compared to low aggressive adolescents. No differences between adolescents showing persistent high rule-breaking and low rule-breaking were found. This longitudinal study is the first to show that persistent aggression, but not rule-breaking behavior, is related to neurobiological alterations. Moreover, despite development of the CAR over adolescence, the decrease in cortisol is consistent over time in persistent high aggressive adolescents, which is an important prerequisite for the prediction of persistent aggression. 相似文献