全文获取类型
收费全文 | 20238篇 |
免费 | 963篇 |
国内免费 | 155篇 |
专业分类
耳鼻咽喉 | 122篇 |
儿科学 | 685篇 |
妇产科学 | 589篇 |
基础医学 | 2291篇 |
口腔科学 | 543篇 |
临床医学 | 1501篇 |
内科学 | 5353篇 |
皮肤病学 | 340篇 |
神经病学 | 2043篇 |
特种医学 | 846篇 |
外国民族医学 | 2篇 |
外科学 | 2757篇 |
综合类 | 53篇 |
一般理论 | 2篇 |
预防医学 | 932篇 |
眼科学 | 270篇 |
药学 | 1144篇 |
中国医学 | 13篇 |
肿瘤学 | 1870篇 |
出版年
2023年 | 144篇 |
2022年 | 277篇 |
2021年 | 542篇 |
2020年 | 314篇 |
2019年 | 461篇 |
2018年 | 561篇 |
2017年 | 393篇 |
2016年 | 531篇 |
2015年 | 552篇 |
2014年 | 785篇 |
2013年 | 969篇 |
2012年 | 1476篇 |
2011年 | 1494篇 |
2010年 | 832篇 |
2009年 | 774篇 |
2008年 | 1405篇 |
2007年 | 1269篇 |
2006年 | 1308篇 |
2005年 | 1209篇 |
2004年 | 1186篇 |
2003年 | 1058篇 |
2002年 | 964篇 |
2001年 | 217篇 |
2000年 | 159篇 |
1999年 | 225篇 |
1998年 | 201篇 |
1997年 | 174篇 |
1996年 | 145篇 |
1995年 | 142篇 |
1994年 | 126篇 |
1993年 | 121篇 |
1992年 | 133篇 |
1991年 | 104篇 |
1990年 | 108篇 |
1989年 | 92篇 |
1988年 | 75篇 |
1987年 | 79篇 |
1986年 | 77篇 |
1985年 | 62篇 |
1984年 | 82篇 |
1983年 | 51篇 |
1982年 | 59篇 |
1981年 | 44篇 |
1980年 | 47篇 |
1979年 | 33篇 |
1978年 | 39篇 |
1977年 | 23篇 |
1976年 | 21篇 |
1974年 | 23篇 |
1972年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Carlo De-Carolis Geraldine-A. Boyd Luca Mancinelli Stefano Pagano Stefano Eramo 《Medicina oral, patología oral y cirugía bucal》2015,20(2):e205-e210
With easy chemical synthesis from its precursor, methamphetamine (MA) is now widespread in many countries. The abuse of methamphetamine is associated with several negative effects on health, because MA is a neurotoxin and a dangerous central nervous system stimulant. It changes levels of neurotransmitters in the brain, releasing dopamine and inhibiting nor epinephrine uptake which increases sympathetic nervous system activity and can lead to cardiac arrhythmia, hypertension and tachypnea. The consequences of MA abuse are clearly manifested in oral diseases (like “meth mouth”) which is characterised by extensive caries, teeth grinding with ensuing dental wear and trismus. The present review was designed to fill the gap in knowledge about methamphetamine abuse in the European Union (EU) and to illustrate the main clinical effects of prolonged use. After describing the pharmacology and systemic effects of methamphetamine and concentrating on its effects on the mouth, the present review compares the epidemiology and incidence of abuse in the world, particularly the USA and the EU.
Key words:Methamphetamine, “Meth mouth”, drug abuse, oral health. 相似文献
2.
3.
4.
5.
6.
Alessandro De Cassai Tommaso Tonetti Helmut Galligioni Carlo Ori 《Brazilian Journal of Anesthesiology》2019,69(1):95-98
Background and objective
Erector spinae plane block is a valid technique to provide simultaneously analgesia for combined thoracic and abdominal surgery.Case report
A patient underwent open esophagectomy followed by reconstructive esophagogastroplasty but refused thoracic epidural analgesia; a multi‐modal analgesia with a multiple erector spinae plane block was then planned. Three erector spinae plane catheters (T5 and T10 on the right side and T9 on the left side) for continuous analgesia were placed before surgery. During the first 48 h pain was never reported in the thoracic area but the patient reported multiple times to feel a pain well localized in epigastrium, but never localized in any other abdominal quadrant.Discussion
Erector spinae plane block is a valid technique to provide analgesia simultaneously for combined thoracic and abdominal surgery and could be a valid alternative strategy if the use of epidural analgesia is contraindicated. 相似文献7.
Carlo Bastianelli V. Bruni Ivo Brosens Giuseppe Benagiano 《Expert review of clinical pharmacology》2020,13(2):163-182
ABSTRACTIntroduction: Steroid hormones are responsible for specific changes in the endometrium during the menstrual cycle, when they are sequentially secreted and, because of this, in the early days sequential combined oral contraceptive regimens were utilized. The same basic concept has been utilized with multi-phasic regimens, in order to produce endometrial pictures mimicking the normal cycle.Areas covered: The Endometrial effects of progestins and estrogens; combined monophasic high- (50 μg), medium- (30 μg), low- (20 μg), ultralow- (15 μg) estrogen content; sequential regimens; multiphasic combinations; treatment schedules.Cervical effects of combined high-dose and sequential combinations, including evidence for an increase in malignant lesions.Expert opinion: Overall, combined oral contraceptives (COCs) inhibit normal proliferative changes and the endometrium becomes thin, narrow, with widely spaced glands and pre-decidual changes in the stroma. During the first few cycles the progestin induces a coexistence of proliferative and secretory features; with time, the picture changes because the progestin induces a down-regulation of estrogen receptors, resulting in tortuous glands similar to those in the secretory phase, but characterized by a quiescent, atrophic glandular epithelium.In the cervical epithelium, under the influence of high-dose COCs, endocervical glands became hypersecretory and in some instances, distinctive type of atypical polypoid endocervical hyperplasia is found. 相似文献
8.
Giorgio Gandaglia Guillaume Ploussard Massimo Valerio Agostino Mattei Cristian Fiori Nicola Fossati Armando Stabile Jean-Baptiste Beauval Bernard Malavaud Mathieu Roumiguié Daniele Robesti Paolo Dell’Oglio Marco Moschini Stefania Zamboni Arnas Rakauskas Francesco De Cobelli Francesco Porpiglia Francesco Montorsi Alberto Briganti 《European urology》2019,75(3):506-514
Background
Available models for predicting lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP) might not be applicable to men diagnosed via magnetic resonance imaging (MRI)-targeted biopsies.Objective
To assess the accuracy of available tools to predict LNI and to develop a novel model for men diagnosed via MRI-targeted biopsies.Design, setting, and participants
A total of 497 patients diagnosed via MRI-targeted biopsies and treated with RP and extended pelvic lymph node dissection (ePLND) at five institutions were retrospectively identified.Outcome measurements and statistical analyses
Three available models predicting LNI were evaluated using the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analyses. A nomogram predicting LNI was developed and internally validated.Results and limitations
Overall, 62 patients (12.5%) had LNI. The median number of nodes removed was 15. The AUC for the Briganti 2012, Briganti 2017, and MSKCC nomograms was 82%, 82%, and 81%, respectively, and their calibration characteristics were suboptimal. A model including PSA, clinical stage and maximum diameter of the index lesion on multiparametric MRI (mpMRI), grade group on targeted biopsy, and the presence of clinically significant PCa on concomitant systematic biopsy had an AUC of 86% and represented the basis for a coefficient-based nomogram. This tool exhibited a higher AUC and higher net benefit compared to available models developed using standard biopsies. Using a cutoff of 7%, 244 ePLNDs (57%) would be spared and a lower number of LNIs would be missed compared to available nomograms (1.6% vs 4.6% vs 4.5% vs 4.2% for the new nomogram vs Briganti 2012 vs Briganti 2017 vs MSKCC).Conclusions
Available models predicting LNI are characterized by suboptimal accuracy and clinical net benefit for patients diagnosed via MRI-targeted biopsies. A novel nomogram including mpMRI and MRI-targeted biopsy data should be used to identify candidates for ePLND in this setting.Patient summary
We developed the first nomogram to predict lymph node invasion (LNI) in prostate cancer patients diagnosed via magnetic resonance imaging-targeted biopsy undergoing radical prostatectomy. Adoption of this model to identify candidates for extended pelvic lymph node dissection could avoid up to 60% of these procedures at the cost of missing only 1.6% patients with LNI. 相似文献9.
Darren R. Feldman MD Yasser Ged MBBS Chung-Han Lee PhD Andrea Knezevic MS Ana M. Molina MD Ying-Bei Chen PhD Joshua Chaim DO Devyn T. Coskey MS Samuel Murray MS Satish K. Tickoo MD Victor E. Reuter MD Sujata Patil PhD Han Xiao MD Jahan Aghalar MD Arlyn J. Apollo MD Maria I. Carlo MD Robert J. Motzer MD Martin H. Voss MD 《Cancer》2020,126(24):5247-5255
10.