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1.
Thanh GN Ton Mary Anne Rossing Deborah J Bowen Sengkeo Srinouanprachan Kristine Wicklund Federico M Farin 《Behavioral and brain functions : BBF》2007,3(1):22-10
Background
Genes involved in dopaminergic neurotransmission have been suggested as candidates for involvement in smoking behavior. We hypothesized that alleles associated with reduced dopaminergic neurotransmission would be more common in continuing smokers than among women who quit smoking. 相似文献2.
Advanced primary breast cancer: assessment at mammography of response to induction chemotherapy 总被引:2,自引:0,他引:2
The response to induction chemotherapy is an important prognostic factor in patients with nonmetastatic, locally advanced breast carcinomas. Assessment at mammography of the response of 60 breast cancers in 59 women was performed between 1974 and 1986. Responses were excellent in 13 tumors, moderate in 34, and poor in 13 (excellent moderate = 78%). Assessment of response of discrete masses in a fatty breast was easiest; assessment of response of tumor areas that were poorly defined-such as a focal area of architectural distortion or mass in dense breast parenchyma-was more difficult. Of 17 patients with excellent pathologic responses-that is, minimal or no residual tumor-15 (88%) had complete responses (no residual tumor) as determined with mammography, physical examination, or both. Mammography provides information complementary to physical examination and is essential in the accurate assessment of the response to chemotherapy of locally advanced breast cancer. 相似文献
3.
4.
Clarke GN; Bourne H; Hill P; Johnston WI; Speirs A; McBain JC; Baker HW 《Human reproduction (Oxford, England)》1997,12(4):722-726
Donor insemination (DI) using cryopreserved semen commenced at The Royal
Women's Hospital in 1976. Over the next 15 years we performed 5953
treatment cycles to achieve 816 pregnancies (13.7% per cycle) and 706 live
births. In-vitro fertilization (IVF) using donor spermatozoa commenced in
1986. Over the next 5 years we performed 303 treatment cycles for 185
couples. Including subsequent transfer of cryopreserved embryos, a total of
33% of couples achieved a successful pregnancy by IVF. Statistical analysis
indicated that, for DI pregnancies, the most important semen variable was
the percentage post-thaw motility, whilst for normal fertilization in IVF
it was the pre-freeze motility. These results may be explained by the
compensatory effects of post-thaw processing of spermatozoa for IVF, but
not for DI in our clinic.
相似文献
5.
水体污染中常见致病菌的多重PCR分子检测研究 总被引:2,自引:0,他引:2
[目的]建立同时检测沙门氏菌、志贺氏菌、绿脓杆菌、肠出血型大肠杆菌和副溶血弧菌等5种水体常见致病菌的多重PCR检测技术,为这些致病菌感染的快速诊断提供实验依据。[方法]筛选设计5对特异引物,建立优化的多重PCR扩增体系和条件。[结果]对5种致病菌的检测,多重PCR灵敏度分别为:肠出血型大肠杆菌O157102 cfu、志贺氏菌102 cfu、副溶血弧菌102 cfu、绿脓杆菌101 cfu、沙门氏菌102 cfu。应用于人工污染水样及天然水样的检测,均有清晰、特异的预期条带产生,并与传统检测结果一致,每个样品所需时间为6~8 h,相对于传统检测方法,极大地缩短了检测时间,提高了检测灵敏度。[结论]该方法适用于大通量样品的检测研究,可推广应用于食品检测、环境监测等领域。 相似文献
6.
Antonia Fuster Jaume Sauleda Ernest Sala Bernard�� Barcel�� Jaume Pons Miguel Carrera Aina Noguera Bernat Togores Alvar GN Agust�� 《INT J CHRONIC OBSTR》2008,3(1):149-153
Objective
Patients with chronic obstructive pulmonary disease (COPD) present systemic inflammation. Strenuous resistive breathing induces systemic inflammation in healthy subjects. We hypothesized that the increased respiratory load that characterizes COPD can contribute to systemic inflammation in these patients.Patients and methods
To test this hypothesis, we compared leukocyte numbers and levels of circulating cytokines (tumor necrosis factor alpha [TNFα], interleukin-1β [IL-1β], IL-6, IL-8, and IL-10), before and 1 hour after maximal incremental inspiratory loading in 13 patients with stable COPD (forced expiratory volume in one second [FEV1] 29 ± 2.5% ref) and in 8 healthy sedentary subjects (FEV1 98 ± 5% ref).Results
We found that: (1) at baseline, patients with COPD showed higher leukocyte counts and IL-8 levels than controls (p < 0.01); and, (2) one hour after maximal inspiratory loading these values were unchanged, except for IL-10, which increased in controls (p < 0.05) but not in patients with COPD.Conclusions
This study confirms the presence of systemic inflammation in COPD, shows that maximal inspiratory loading does not increase the levels of pro-inflammatory cytokines (IL-1β, IL-8) in COPD patients or controls, but suggests that the former may be unable to mount an appropriate systemic anti-inflammatory response to exercise. 相似文献7.
ObjectiveTo determine the prevalence of Trichomonas vaginalis (T. vaginalis) in HIV/AIDS patients attending two different hospitals in southeast Nigeria.MethodsWe collected 970 urine samples from HIV/AIDS patients attending two different hospitals in southeast Nigeria. Samples were processed by microscopy and cultural methods.ResultsOut of the 970 screened, 355 (36.60%) were positive for T. vaginalis. Subjects with the least CD4+ count in the range of 40-140 cells/mL had the highest number of positive samples (180, 50.70%), while those in the range of 480-580 cells/mL had the least value (2, 0.56%). Those in the rural areas had a higher number of positive samples (155, 38.75%) than their urban counterparts (200, 35.09%) with respect to the total number examined in each group but this was not statistically significant (P>0.05). Out of the 355 positive cases, the university undergraduate students’ group had the highest percentage incidence of 53.00% followed by the low-income group with 47.08%.ConclusionsIt can be concluded that the occurrence of T. vaginalis increases with decrease in the CD4+ counts in HIV/AIDS patients in Nigeria. Since T. vaginalis may be an important cofactor in promoting the spread of HIV and, in some circumstances, may have a major impact on the epidemic dynamics of HIV, there is a need to take measures to check the spread of this parasitic infection. 相似文献
8.
目的 探讨相对健康的中老年人血中糖化血红蛋白(HbAlc)含量对颈动脉硬化的影响.方法 从广州生物库队列中单纯随机抽样收集1863名年龄≥50岁的广州市居民的个人资料,问卷调查其病史、体格检查及测定血清空腹血糖、血脂、HbA1c的含量并应用彩色多普勒超声测量颈总动脉内膜-中层厚度(intima media thickness,IMT).在调整相关混染因素后,应用协方差分析进行连续变量分析.结果 (1)在调整年龄、性别和空腹血糖等因素后,平均颈总动脉IMT随HbA1c含量升高呈明显增加趋势(P=0.005).线性回归模型显示,在调整年龄、性别、吸烟状态、腰围、收缩压和舒张压、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和空腹血糖等潜在危险因素后,结果仍然显示HbA1c水平与平均颈总动脉IMT有明显的线性相关(回归系数为0.014,P=0.03);(2)经过调整多种潜在混杂因素后,与HbA1c理想组(HbA1c<6.5%)比较,良好组(HbA1c为6.5%~7.5%)和差组(HbA1c>7.5%)发生颈动脉硬化的比值比(95%置信区间)分别为1.62(1.10,2.38)和1.76(0.86,3.63),趋势检验(P=0.01).结论 相对健康的中老年人HbA1c含量升高是颈动脉硬化的独立危险因素之一,提示降低HbA1c水平对阻止或延缓颈动脉硬化的发生与发展有重要意义. 相似文献
9.
Patients with acquired defects or congenital malformations of the palate exhibit disturbances in speech, including hypernasality, nasal emission, and decreased intelligibility of speech. Maxillofacial prosthetic treatment can reestablish the palatopharyngeal integrity to provide the potential for acceptable speech. This article describes a case series of patients with palatopharyngeal disorders and their treatment approaches. 相似文献
10.
Fluoride ions have more affinity towards chitosan material. Fish scales waste is chitosan material generated in abundance in fish markets with virtually no value. The present research attempts to convert this waste to useful adsorbent which can remove fluoride from water. A novel adsorbent is thus developed from the Labeo rohita (rohu) fish scales waste giving thermal treatment for removal of fluoride from water using the batch study of adsorption. Taguchi optimization approach with L16 orthogonal array was adopted to optimize the process parameters for achieving the maximum removal of fluoride. Using ANOM, pH 3; initial F? concentration 5 mg.L?1; mixing time 90 min; adsorbent dose 8 g.L?1 and temperature 303 OK were obtained as optimum values providing a maximum fluoride reduction of 93.32%. Adopting ANOVA, the percentage contribution of each process parameter in descending order of sequence is initial F? concentration 72.44%> pH 20.61% > temperature 2.96% > adsorbent dose 2.45% > contact time 1.55%. The fluoride sorption onto fish scales adsorbent was best fitted with the pseudo-second-order kinetic model and follows the Freundlich isotherm (KF = 0.865, 1/n = 0.407) model. Thermodynamic parameters (ΔS = ?6.32 J mol?1.K?1, and ΔH = ?2.02 kJ mol?1) suggested a spontaneous, exothermic nature of adsorption and indicates a physiosorption mechanism on a heterogeneous material. SEM and FTIR analysis for surface morphology showed the presence of hydroxyl functional groups is responsible for fluoride sorption. In the regeneration studies, the F – exhausted adsorbent was eluted with 0.1 N NaOH and rinsed with distilled water to prepare the adsorbent for the next cycle. The study indicates the removal of fluoride from water onto fish scales adsorbent is quite feasible, cost-effective, recyclable, and better utilization of locally available waste material into useful adsorbent for defluoridation of water. 相似文献