全文获取类型
收费全文 | 1015篇 |
免费 | 41篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 44篇 |
妇产科学 | 21篇 |
基础医学 | 96篇 |
口腔科学 | 21篇 |
临床医学 | 99篇 |
内科学 | 233篇 |
皮肤病学 | 23篇 |
神经病学 | 36篇 |
特种医学 | 179篇 |
外科学 | 118篇 |
综合类 | 19篇 |
预防医学 | 41篇 |
眼科学 | 10篇 |
药学 | 99篇 |
中国医学 | 4篇 |
肿瘤学 | 39篇 |
出版年
2021年 | 9篇 |
2018年 | 11篇 |
2017年 | 9篇 |
2015年 | 13篇 |
2014年 | 18篇 |
2013年 | 23篇 |
2012年 | 18篇 |
2011年 | 19篇 |
2010年 | 21篇 |
2009年 | 33篇 |
2008年 | 21篇 |
2007年 | 37篇 |
2006年 | 28篇 |
2005年 | 15篇 |
2004年 | 20篇 |
2003年 | 17篇 |
2002年 | 21篇 |
2001年 | 25篇 |
2000年 | 24篇 |
1999年 | 29篇 |
1998年 | 53篇 |
1997年 | 51篇 |
1996年 | 43篇 |
1995年 | 30篇 |
1994年 | 28篇 |
1993年 | 33篇 |
1992年 | 15篇 |
1991年 | 22篇 |
1990年 | 15篇 |
1989年 | 36篇 |
1988年 | 24篇 |
1987年 | 28篇 |
1986年 | 21篇 |
1985年 | 28篇 |
1984年 | 23篇 |
1983年 | 28篇 |
1982年 | 16篇 |
1981年 | 22篇 |
1980年 | 20篇 |
1979年 | 9篇 |
1978年 | 19篇 |
1977年 | 12篇 |
1976年 | 10篇 |
1975年 | 13篇 |
1974年 | 7篇 |
1973年 | 10篇 |
1972年 | 11篇 |
1971年 | 8篇 |
1970年 | 10篇 |
1965年 | 10篇 |
排序方式: 共有1095条查询结果,搜索用时 15 毫秒
1.
2.
3.
G. Borkowski H. Sudhofft H. Luckhauptt S. Philippou H. Hildmann 《European journal of plastic surgery》1997,20(2):107-109
Dermatofibrosarcoma protuberans (DFSP) previously called Morbus Darier is an intermediate grade sarcoma with a fairly high rate of recurrence, it occurs most commonly on the trunk and extremities but may also occur in the head and neck region. Treatment of choice is wide excision. A 69-year-old female patient with a 57-year history of dermatofibrosarcoma protuberans is presented. The lesion appeared on the right forehead and both eyelids at the age of 12 years. The patient required 64 surgeries mostly for the head and neck lesions. 相似文献
4.
L. Bablok M. Czaplicki S. Fracki L. Marianowski A. Borkowski 《International urology and nephrology》1997,29(3):345-349
Evaluation of serum levels of FSH, LH, prolactin, testosterone and oestradiol is not predictive of the increases of sperm
count after varicocelectomy. Increased level of oestradiol reflects the lack of possibility of sperm motility increase after
varicocelectomy. 相似文献
5.
Cesare Mondadori Conrad Gentsch Bastian Hengerer Thomas Ducret Jürgen Borkowski Amy Racine Renate Lederer Albert Haeusler 《Psychopharmacology》1992,109(4):383-389
Oral pretreatment with aldosterone or corticosterone blocked the memory-enhancing effects of the calcium antagonist nimodipine, the ACE inhibitor captopril, the NMDA blocker CGP 37 849, and the glycine antagonist strychnine in a passive-avoidance test in mice. The memory-disturbing effects of phenobarbitone, diazepam, CGP 37 849 and scopolamine were not influenced by the hormonal pretreatment. These findings could indicate the involvement of a steroid-sensitive mechanism in drug-induced improvement of memory. In the light of clinical observations showing elevated cortisol levels in Alzheimer patients, the results might also explain why only a limited number of these patients respond to therapy with memory enhancers. 相似文献
6.
7.
Normal and diseased isolated lungs: high-resolution CT 总被引:8,自引:0,他引:8
8.
Tumor targeting by an aptamer. 总被引:10,自引:0,他引:10
Brian J Hicke Andrew W Stephens Ty Gould Ying-Fon Chang Cynthia K Lynott James Heil Sandra Borkowski Christoph-Stephan Hilger Gary Cook Stephen Warren Paul G Schmidt 《Journal of nuclear medicine》2006,47(4):668-678
Aptamers are small oligonucleotides that are selected to bind tightly and specifically to a target molecule. We sought to determine whether aptamers have potential for in vivo delivery of radioisotopes or cytotoxic agents. METHODS: TTA1, an aptamer to the extracellular matrix protein tenascin-C, was prepared in fluorescent and radiolabeled forms. After in vivo administration, uptake and tumor distribution of Rhodamine Red-X-labeled aptamer was studied by fluorescence microscopy. In glioblastoma (U251) and breast cancer (MDA-MB-435) tumor xenografts, biodistribution and imaging studies were performed using TTA1 radiolabeled with (99m)Tc. Tenascin-C levels and tumor uptake were studied in a variety of additional human tumor xenografts. To assess the effect of radiometal chelate on biodistribution, mercapto-acetyl diglycine (MAG(2)) was compared with diethylenetriaminepentaacetic acid and with MAG(2)-3,400-molecular-weight PEG (PEG(3,400)). RESULTS: Intravenous injection of fluorescent aptamer TTA1 produced bright perivascular fluorescence in a xenografted human tumor within 10 min. In the ensuing 3 h, fluorescence diffused throughout the tumor. Labeled with (99m)Tc, TTA1 displayed rapid blood clearance, a half-life of less than 2 min, and rapid tumor penetration: 6% injected dose (%ID)/g at 10 min. Tumor retention was durable, with 2.7 %ID/g at 60 min and a long-lived phase that stabilized at 1 %ID/g. Rapid tumor uptake and blood clearance yielded a tumor-to-blood ratio of 50 within 3 h. Both renal and hepatic clearance pathways were observed. Using the (99m)Tc-labeled aptamer, images of glioblastoma and breast tumors were obtained by planar scintigraphy. Aptamer uptake, seen in several different human tumors, required the presence of the target protein, human tenascin-C. Modification of the MAG(2) radiometal chelator dramatically altered the uptake and clearance patterns. CONCLUSION: TTA1 is taken up by a variety of solid tumors including breast, glioblastoma, lung, and colon. Rapid uptake by tumors and rapid clearance from the blood and other nontarget tissues enables clear tumor imaging. As synthetic molecules, aptamers are readily modified in a site-specific manner. A variety of aptamer conjugates accumulate in tumors, suggesting imaging and potentially therapeutic applications. 相似文献
9.
10.
The adhesion of hematopoietic progenitor cells to bone marrow stromal cells is critical to hematopoiesis and involves multiple effector molecules. Stromal cell molecules that participate in this interaction were sought by analyzing the detergent-soluble membrane proteins of GBI/6 stromal cells that could be adsorbed by intact FDCP-1 progenitor cells. A single-chain protein from GBI/6 cells having an apparent molecular weight of 37 Kd was selectively adsorbed by FDCP-1 cells. This protein, designated p37, could be surface-radiolabeled and thus appeared to be exposed on the cell membrane. An apparently identical 37- Kd protein was expressed by three stromal cell lines, by Swiss 3T3 fibroblastic cells, and by FDCP-1 and FDCP-2 progenitor cells. p37 was selectively adsorbed from membrane lysates by a variety of murine hematopoietic cells, including erythrocytes, but not by human erythrocytes. Binding of p37 to cells was calcium-dependent, and was not affected by inhibitors of the hematopoietic homing receptor or the cell-binding or heparin-binding functions of fibronectin. It is proposed that p37 may be a novel adhesive molecule expressed on the surface of a variety of hematopoietic cells that could participate in both homotypic and heterotypic interactions of stromal and progenitor cells. 相似文献