全文获取类型
收费全文 | 4525篇 |
免费 | 437篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 134篇 |
儿科学 | 103篇 |
妇产科学 | 140篇 |
基础医学 | 650篇 |
口腔科学 | 80篇 |
临床医学 | 525篇 |
内科学 | 774篇 |
皮肤病学 | 43篇 |
神经病学 | 322篇 |
特种医学 | 294篇 |
外科学 | 670篇 |
综合类 | 124篇 |
一般理论 | 2篇 |
预防医学 | 434篇 |
眼科学 | 116篇 |
药学 | 337篇 |
中国医学 | 3篇 |
肿瘤学 | 213篇 |
出版年
2023年 | 46篇 |
2022年 | 36篇 |
2021年 | 73篇 |
2020年 | 72篇 |
2019年 | 91篇 |
2018年 | 110篇 |
2017年 | 80篇 |
2016年 | 90篇 |
2015年 | 92篇 |
2014年 | 115篇 |
2013年 | 182篇 |
2012年 | 251篇 |
2011年 | 258篇 |
2010年 | 124篇 |
2009年 | 128篇 |
2008年 | 210篇 |
2007年 | 183篇 |
2006年 | 210篇 |
2005年 | 215篇 |
2004年 | 205篇 |
2003年 | 175篇 |
2002年 | 185篇 |
2001年 | 98篇 |
2000年 | 115篇 |
1999年 | 92篇 |
1998年 | 45篇 |
1997年 | 43篇 |
1996年 | 50篇 |
1995年 | 54篇 |
1994年 | 44篇 |
1993年 | 44篇 |
1992年 | 115篇 |
1991年 | 87篇 |
1990年 | 77篇 |
1989年 | 79篇 |
1988年 | 64篇 |
1987年 | 69篇 |
1986年 | 58篇 |
1985年 | 66篇 |
1984年 | 54篇 |
1983年 | 47篇 |
1981年 | 25篇 |
1980年 | 28篇 |
1979年 | 26篇 |
1978年 | 35篇 |
1977年 | 26篇 |
1976年 | 29篇 |
1974年 | 39篇 |
1973年 | 34篇 |
1972年 | 24篇 |
排序方式: 共有4964条查询结果,搜索用时 31 毫秒
1.
2.
AbstractThis article follows up a pilot project to help educate local nurses and patient educators on freely available consumer health resources. The Outreach Coordinator and Clinical Librarian at an academic medical center created a one-hour in-person and online class with continuing education credit and an online guide. Nurses frequently act as patient educators at the bedside and are therefore an important target for consumer health education. While nurses in an urban setting may have more access to educational opportunities, these opportunities are needed even more in rural settings. Librarians can obtain funding to travel and teach classes at rural community hospitals. 相似文献
3.
Cough and paradoxical vocal fold motion 总被引:8,自引:0,他引:8
Kenneth W. Altman MD PhD C. Blake Simpson MD Milan R. Amin MD Mona Abaza MD Ron Balkissoon MD Roy R. Casiano MD 《Otolaryngology--head and neck surgery》2002,127(6):501-511
OBJECTIVES: The differential diagnosis and treatment of patients with chronic cough, paradoxical vocal fold motion, and disordered breathing can be a challenge to most practicing otolaryngologists. Tracheobronchial (ie, asthma, bronchitis, and tracheal stenosis), laryngeal (ie, vocal fold paralysis and neoplasms), and rhinologic (ie, allergies and rhinosinusitis) etiologies are commonly diagnosed and treated effectively. However, occasionally one is faced with patients who are refractory to medical treatment and have no obvious rhinologic, laryngeal or pulmonary cause. STUDY DESIGN AND SETTING: We conducted a review of the literature. METHODS: We present a thorough review of the current medical literature exploring the complex neurologic mechanisms involved in the production of cough and the relationship between gastroesophageal reflux disease, vagal neurapathy, and paradoxical vocal fold motion. RESULTS: The diagnosis and successful treatment of chronic cough can be complex. It requires a thorough understanding of the neurologic mechanisms behind cough excitation and suppression. Successful treatment strategies include aggressive management of the patient's reactive airway disease, gastroesophageal reflux disease, and, in select cases, paradoxical vocal fold motion. This may involve a well-coordinated effort among pulmonologists, otolaryngologists, gastroenterologists, and speech pathologists. CONCLUSION: Gastroesophageal reflux disease, vagal neuropathy, and paradoxical vocal fold motion are additional causes of chronic cough and disordered breathing that need to be considered, in the absence of obvious laryngotracheal and/or rhinologic pathology. A high index of suspicion is essential in making the diagnosis and formulating an effective multidisciplinary treatment plan for these patients. 相似文献
4.
5.
The cytoskeleton is susceptible to oxidative stress and this occurs prior to membrane blebbing and cell lysis. Vimentin intermediary filaments in rheumatoid synoviocytes are more susceptible than in normal synoviocytes and this may have pathological significance. They are however no more susceptible to heat shock than other cell types. 相似文献
6.
Max Heiland Philipp Pohlenz Marco Blessmann Christian R Habermann Lars Oesterhelweg Philipp C Begemann Christian Schmidgunst Felix A S Blake Klaus Püschel Rainer Schmelzle Dirk Schulze 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(6):814-820
OBJECTIVE: The aim of this study was to evaluate soft tissue image quality of a mobile cone-beam computed tomography (CBCT) scanner with an integrated flat-panel detector. STUDY DESIGN: Eight fresh human cadavers were used in this study. For evaluation of soft tissue visualization, CBCT data sets and corresponding computed tomography (CT) and magnetic resonance imaging (MRI) data sets were acquired. Evaluation was performed with the help of 10 defined cervical anatomical structures. RESULTS: The statistical analysis of the scoring results of 3 examiners revealed the CBCT images to be of inferior quality regarding the visualization of most of the predefined structures. Visualization without a significant difference was found regarding the demarcation of the vertebral bodies and the pyramidal cartilages, the arteriosclerosis of the carotids (compared with CT), and the laryngeal skeleton (compared with MRI). Regarding arteriosclerosis of the carotids compared with MRI, CBCT proved to be superior. CONCLUSIONS: The integration of a flat-panel detector improves soft tissue visualization using a mobile CBCT scanner. 相似文献
7.
Philipp Pohlenz Marco Blessmann Felix Blake Sven Heinrich Rainer Schmelzle Max Heiland 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,103(3):412-417
OBJECTIVES: Intraoperative cone-beam computerized tomography (CBCT) imaging has been introduced in oral and maxillofacial surgery. Using midfacial fractures as the pioneer model, this study describes the spectrum of further promising clinical indications for intraoperative CBCT and a clinical combination with intraoperative navigation. STUDY DESIGN: One hundred seventy-nine patients admitted for surgical treatment of the facial skeleton were included in the study. Intraoperatively, 3-dimensional images were generated with the mobile CBCT scanner Arcadis Orbic 3D, obtained from Siemens Medical Solutions, in a variety of indications. RESULTS: The acquisition of the data sets was uncomplicated, and image quality was sufficient to assess the postoperative result in all cases. In the example of a facial gunshot injury, a navigation system for intraoperative localization of the metal foreign bodies was used. 相似文献
8.
Usha Chinappen-Horsley Glen M Blake Ignac Fogelman Tim D Spector 《BMC musculoskeletal disorders》2007,8(1):113
Background
Skeletal ratios and bone lengths are widely used in anthropology and forensic pathology and hip axis length is a useful predictor of fracture. The aim of this study was to show that skeletal ratios, such as length of femur to height, could be accurately measured from a DXA (dual energy X-ray absorptiometry) image. 相似文献9.
J Chhabra Y-Z Li H Alkhouri A E Blake Q Ge C L Armour J M Hughes 《The European respiratory journal》2007,29(5):861-870
Degranulating mast cells are increased in the airway smooth muscle (ASM) of asthmatics, where they may influence ASM function. The aim of the present study was to determine whether histamine and tryptase modulate ASM cell granulocyte-macrophage colony-stimulating factor (GM-CSF) and RANTES (regulated on activation, normal T-cell expressed and secreted) release and also to examine which receptors are involved in this release. Confluent, quiescent ASM cells from asthmatic and nonasthmatic donors were treated with histamine (1 microM-100 microM) with and without histamine receptor antagonist pre-treatment, or the protease-activated receptor (PAR)-2 agonists tryptase (0.5-5 nM) and SLIGKV (100 and 400 microM). The cells were then stimulated with interleukin (IL)-1beta and/or tumour necrosis factor (TNF)-alpha (10 ng.mL(-1)) or left unstimulated for 24 h. Release of GM-CSF and RANTES was determined by ELISA and prostaglandin (PG)E(2) measured by enzyme immunoassay. Neither histamine nor tryptase induced ASM GM-CSF or RANTES secretion. However, histamine increased IL-1beta-induced GM-CSF release and markedly reduced TNF-alpha-induced RANTES release by both asthmatic and nonasthmatic cells to a similar extent, but did not modulate PGE(2) release. All changes involved activation of the histamine H1 receptor as they were partially or fully blocked by chlorpheniramine, but not ranitidine. Tryptase, via its proteolytic activity, also potentiated GM-CSF, but not RANTES, release from asthmatic and nonasthmatic ASM cells induced by both cytokines. PAR-2 involvement in the tryptase potentiation was unlikely because SLIGKV had no effect. In conclusion, mast cells, through histamine and tryptase, may locally modulate airway smooth muscle-induced inflammation in asthma. 相似文献
10.
Biliary stent causing colovaginal fistula: case report. 总被引:2,自引:0,他引:2
Anna-Maria Blake Narinder Monga Ernest M Dunn 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2004,8(1):73-75
OBJECTIVES: Perforation of the bowel during placement of a biliary stent is a known complication of this procedure. We report the endoluminal loss of a biliary stent during routine stent extraction that ultimately led to a chronic colovaginal fistula. This case emphasizes the need for evaluation of fecal passage of stents in patients with a known dislodged prosthesis. CASE REPORT: A 65-year-old white female underwent biliary stent placement for an episode of choledocholithiasis. The stent was lost in the duodenum during routine extraction. The patient was managed expectantly. She denied ever passing this stent via the rectum and began to develop symptoms of colovaginal fistula. Evaluation found a retained biliary stent in the sigmoid colon and a fistula into the vagina. The patient underwent elective low anterior resection and colovaginal fistula repair. DISCUSSION: Reports exist of migration of stents that lead to acute colonic perforation and the need for emergent surgery. For this reason, it has been suggested that dropped or migrated stents be purposefully retrieved. However, if the option of expectant observation is used, it is important to clearly document the fecal passage of these stents and be prepared to retrieve these objects if they have a prolonged bowel transit time. 相似文献