全文获取类型
收费全文 | 1258篇 |
免费 | 83篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 144篇 |
妇产科学 | 19篇 |
基础医学 | 98篇 |
口腔科学 | 33篇 |
临床医学 | 185篇 |
内科学 | 245篇 |
皮肤病学 | 12篇 |
神经病学 | 45篇 |
特种医学 | 249篇 |
外科学 | 109篇 |
综合类 | 21篇 |
一般理论 | 1篇 |
预防医学 | 95篇 |
眼科学 | 18篇 |
药学 | 38篇 |
中国医学 | 5篇 |
肿瘤学 | 29篇 |
出版年
2023年 | 8篇 |
2021年 | 14篇 |
2020年 | 7篇 |
2019年 | 7篇 |
2018年 | 23篇 |
2017年 | 14篇 |
2016年 | 19篇 |
2015年 | 23篇 |
2014年 | 28篇 |
2013年 | 28篇 |
2012年 | 23篇 |
2011年 | 30篇 |
2010年 | 41篇 |
2009年 | 59篇 |
2008年 | 36篇 |
2007年 | 21篇 |
2006年 | 25篇 |
2005年 | 17篇 |
2004年 | 11篇 |
2003年 | 20篇 |
2002年 | 19篇 |
2001年 | 25篇 |
2000年 | 23篇 |
1999年 | 21篇 |
1998年 | 56篇 |
1997年 | 56篇 |
1996年 | 74篇 |
1995年 | 51篇 |
1994年 | 49篇 |
1993年 | 50篇 |
1992年 | 25篇 |
1991年 | 14篇 |
1990年 | 26篇 |
1989年 | 40篇 |
1988年 | 41篇 |
1987年 | 44篇 |
1986年 | 43篇 |
1985年 | 33篇 |
1984年 | 22篇 |
1983年 | 18篇 |
1982年 | 26篇 |
1981年 | 19篇 |
1980年 | 11篇 |
1979年 | 12篇 |
1978年 | 12篇 |
1977年 | 23篇 |
1976年 | 19篇 |
1975年 | 18篇 |
1973年 | 4篇 |
1972年 | 7篇 |
排序方式: 共有1349条查询结果,搜索用时 15 毫秒
1.
ME BURGE AM JOSHUA CM McNEIL R HUI MJ BOYER R ABRAHAM 《Asia-Pacific Journal of Clinical Oncology》2005,1(1):47-52
Background: Pemetrexed and cisplatin have recently been shown to significantly improve survival compared with cisplatin alone. However, there are only limited data reflecting teaching hospital experience outside a clinical trial. Pemetrexed has only been available in Australia on a restricted basis since 2002. We reviewed our experience of patients treated on the Australian ‘Special Access Scheme’ at three major thoracic oncology units. Methods: Charts were reviewed for all patients enrolled on the scheme. Data was extracted on age, World Health Organization (WHO) performance status, histology, prior therapy, time from diagnosis to starting pemetrexed, chemotherapy (pemetrexed alone or with a platinum), cycle number, response rate, actuarial progression‐free and overall survival. Doses were cisplatin 75 mg/m2 or carboplatin AUC = 5 and pemetrexed 500 mg/m2 every 21 days. Results: 52 patients (32 male and 20 female) were reviewed. Median age was 58 years and 88% were WHO 0–1. Histology included 54% epithelial, 17% biphasic (epithelial and sarcomatoid) and 21% undefined. The median time from diagnosis to administration of pemetrexed was 145 days. Sixty‐five percent had minimal surgical intervention with video assisted thoracoscopy, pleurodesis and biopsy, while 19% had received prior palliative radiation. Seventy‐one percent were chemotherapy naïve, the remaining 29% having received previous platinum and/or gemcitabine regimens. Twenty‐three percent had pemetrexed alone, 35% in combination with carboplatin and 42% with cisplatin. The median number of cycles was 4 (range 1–13). The response rate was 33%. No toxicity was observed in 20% grade 3–4 toxicity in 10% (majority nausea/vomiting). The median progression‐free and overall survival times from starting pemetrexed were 184 days and 298 days, respectively. Conclusions: Pemetrexed‐based regimens are safe and effective in a community setting in malignant mesothelioma. 相似文献
2.
3.
4.
5.
6.
E Seidman N LeLeiko M Ament W Berman D Caplan J Evans S Kocoshis A Lake K Motil J Sutphen 《Journal of pediatric gastroenterology and nutrition》1991,12(4):424-438
Malnutrition, characterized by weight loss, growth failure and micronutrient depletion, are prominent features of inflammatory bowel disease (IBD) in the pediatric age group. Accurate evaluation of the patient's nutritional status and appropriate nutritional support, whether enteral or parenteral, constitute integral parts of the management of the growing child with IBD. Over the past two decades, a number of studies have supported the potential use of nutritional therapy to induce remission and to control disease activity in symptomatic Crohn's disease. More recently, preliminary studies on the use of dietary supplements of marine-oil-derived omega-3 fatty acids have also indicated a beneficial effect in IBD patients. In parallel with these clinical trials, scientific research has recently focused on the concept that specific dietary alterations can modulate the immune response. Components of the diet that may have particular relevance to mucosal immunity and the pathogenesis of IBD include polyunsaturated fatty acids, nucleotides, and amino acids such as glutamine and arginine. Future research in the interactions between specific nutrients and the immune system will likely increase our understanding of the causes of IBD, as well as enhance the development of novel nutritional therapies for IBD patients. 相似文献
7.
8.
9.
10.