全文获取类型
收费全文 | 94篇 |
免费 | 7篇 |
专业分类
儿科学 | 4篇 |
基础医学 | 18篇 |
临床医学 | 14篇 |
内科学 | 31篇 |
皮肤病学 | 3篇 |
神经病学 | 7篇 |
外科学 | 16篇 |
综合类 | 1篇 |
预防医学 | 1篇 |
药学 | 1篇 |
中国医学 | 2篇 |
肿瘤学 | 3篇 |
出版年
2021年 | 1篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 3篇 |
2009年 | 5篇 |
2008年 | 4篇 |
2006年 | 3篇 |
2005年 | 3篇 |
2004年 | 2篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 3篇 |
1998年 | 4篇 |
1997年 | 13篇 |
1996年 | 7篇 |
1995年 | 6篇 |
1994年 | 5篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1959年 | 1篇 |
1958年 | 1篇 |
1957年 | 2篇 |
1956年 | 3篇 |
1954年 | 1篇 |
排序方式: 共有101条查询结果,搜索用时 0 毫秒
1.
AKIHISA MITSUDOME SAWA YASUMOTO SHIU FUKAMI ATSUSHI OGAWA 《Pediatrics international》1997,39(3):392-394
A Japanese boy with Kabuki make-up syndrome associated with West syndrome is reported. He developed periodic tonic spasms at 6 months of age while his electro-encephalogram also revealed hypsarrhythmia. Although only a few previously reported cases of Kabuki make-up syndrome have been associated with epilepsy, it is likely that epileptic seizures are another primary feature of Kabuki make-up syndrome. 相似文献
2.
YUKAKO ISHIHARA MASAHIRO SEIKE ITARU YOKOUCHI HIROAKI SUDA SHUNICHIRO ISHITSUKA TADAYOSHI KAKEMURA MITSUHIRO YOSHIDA KAZUYA YOSHIMOTO YOSHIHIRO SAKAI CHIDORI OKUMURA YOSHIHISA SAIDA 《Digestive endoscopy》2003,15(3):240-242
A 55‐year‐old‐man had a laparoscopic resection of the sigmoid colon due to colon cancer with submucosal invasion. After the surgery he suffered ileus and had a laparotomy. Six months later he complained of frequent defecation. Colonoscopy confirmed a circular ulcer extending from the anal side of the anastomosis in the sigmoid colon to the mid rectum. Endoscopic ultrasound demonstrated thickening of all layers of the diseased colon and rectum. We diagnosed ischemic colitis. After intravenous drip infusion of prostaglandin, symptoms and colonic stricture gradually improved. Although abdominal angiography revealed a narrowing of the peripheral sigmoid branch of the inferior mesenteric artery, blood flow was unrestricted. Colonoscopy performed 84 days after discharge revealed an ulcer scar. 相似文献
3.
AKIHISA FUKUDA TORU KAJIYAMA HIROYUKI KISHIMOTO HIROAKI ARAKAWA HITOSHI SOMEDA MASAHIKO SAKAI HIROSHI SENO TSUTOMU CHIBA 《Journal of gastroenterology and hepatology》2006,20(1):46-50
Background: Bleeding is one of the main symptoms of internal hemorrhoids. However, the conventional Goligher's classification of internal hemorrhoids does not consider the severity of bleeding. We intended to establish a useful method for evaluating internal hemorrhoids using a colonoscope that reflected the severity of the symptoms.
Methods: Using a colonoscope in the retroflexed and forward viewing position, 104 patients with symptomatic internal hemorrhoids were evaluated based on the criteria of range, form and red color signs (RCS). Range was determined by the circumferential distribution of internal hemorrhoids and scaled from 0 to 4. Form was determined by size and scaled from 0 to 2. The presence of RCS was also evaluated. Symptoms were determined by interview and scaled from 0 to 3. Patients were treated by endoscopic band ligation (EBL) and were examined endoscopically before and 4 weeks after the treatment.
Results: Before the treatment, range, form and RCS were significantly correlated to bleeding ( P < 0.01), and form was significantly correlated to prolapse ( P < 0.05). The endoscopic classification scores at 4 weeks after EBL improved significantly (range from 3.25 ± 0.05–0.56 ± 0.08 [ P < 0.01] and form from 2.81 ± 0.04–0.56 ± 0.07 P < 0.01).
Conclusion: The new endoscopic classification of internal hemorrhoids proved to be closely correlated to symptoms, particularly bleeding, and thus highly useful in evaluating the effectiveness of the treatment. 相似文献
Methods: Using a colonoscope in the retroflexed and forward viewing position, 104 patients with symptomatic internal hemorrhoids were evaluated based on the criteria of range, form and red color signs (RCS). Range was determined by the circumferential distribution of internal hemorrhoids and scaled from 0 to 4. Form was determined by size and scaled from 0 to 2. The presence of RCS was also evaluated. Symptoms were determined by interview and scaled from 0 to 3. Patients were treated by endoscopic band ligation (EBL) and were examined endoscopically before and 4 weeks after the treatment.
Results: Before the treatment, range, form and RCS were significantly correlated to bleeding ( P < 0.01), and form was significantly correlated to prolapse ( P < 0.05). The endoscopic classification scores at 4 weeks after EBL improved significantly (range from 3.25 ± 0.05–0.56 ± 0.08 [ P < 0.01] and form from 2.81 ± 0.04–0.56 ± 0.07 P < 0.01).
Conclusion: The new endoscopic classification of internal hemorrhoids proved to be closely correlated to symptoms, particularly bleeding, and thus highly useful in evaluating the effectiveness of the treatment. 相似文献
4.
SHINICHI KAKUMU MASAHIRO TAKAYANAGI KAZUO IWATA AKIHIKO OKUMURA TOSHIYUKI AIYAMA TETSUYA ISHIKAWA MASAYUKI NADAI KENTARO YOSHIOKA 《Journal of gastroenterology and hepatology》1997,12(1):62-66
Interferon (IFN) therapy is of proven efficacy in chronic hepatitis C, but it is not universally effective and is often limited by side effects. Cyclosporine A (CsA) is a potent immunosuppressant widely used in organ transplantation. We conducted a pilot study to determine whether CsA therapy could affect aminotransferase activity and hepatitis C virus RNA levels in patients with chronic hepatitis C. Cyclosporine A was administered to 10 patients (mean age of 59 years; male: female = 9:1) who did not respond to IFN therapy previously and who had elevated serum alanine aminotransferase (ALT) values for at least 6 months. All patients were positive for HCV-RNA by RT-PCR with genotype 1b. Their mean duration of hepatitis was 15 years. Oral CsA was given for 3 months in a dose that was increased at 1 month intervals from 1.5–2.0 to 2.0–3.0 and 3.0–4.0 mg/kg per day. All patients completed the treatment schedule, although two patients developed mild non-symptomatic hypertension. Serum ALT levels gradually decreased in all but one patient. The mean percentage decrease was 59.5% at the end of therapy (from 153 ± 82 to 62 ± 48 IU/L; P < 0.02). The ALT levels fell to the normal range in five patients, although once therapy was discontinued the enzyme levels tended to return to pretreatment levels. Serum aspartate aminotransferase and g-glutamyl transpeptidase levels similarly decreased. The serum HCV-RNA titre, determined by competitive RT-PCR, did not change in any patient throughout the study period. There were no appreciable alterations in other laboratory tests, such as serum creatinine levels and lymphocyte subsets, except for an increase in serum alkaline phosphatase levels. These findings suggest that CsA, even in a relatively low dose, reduces serum aminotransferase levels without serious side effects in patients with chronic-hepatitis C, although an antiviral effect was not noted. 相似文献
5.
HISATOME I.; KOTAKE H.; OGINO K.; ISHIKO R.; HASEGAWA J.; MASHIBA H.; SATO R.; OKUMURA H. 《Rheumatology (Oxford, England)》1989,28(6):525-527
We report five female cases of hypouricaemia accompanied byacute viral hepatitis (serum urate 101 ± 12 µmol/1,mean ± SD). Their urate clearance was increased to 14.2±3.4 ml/min during hyperbilirubinaemia but 24-h urateexcretion was not elevated (2.09 ± 0.64 mmol/24 h). Noother renal tubular abnormalities were detected. Comparing uratemetabolism with that of four cases of inborn renal hypouricaemia,the degree of uricosuria was lower. One patient showed elevationof serum and urinary oxypurine, which normalized with returnof a normal blood uric acid level. In all cases, the serum uratereturned to normal after improvement of liver function. We suggestthat renal uricosuria due to an isolated renal defect of uratetransport might contribute to hypouricaemia in these cases butthat inhibition of xanthine oxidase activity might also contributeto this phenomenon. KEY WORDS: Liver disease, Purine synthesisPurine synthesis, Purine synthesis, Kidney, Tubular function, Xanthine oxidase 相似文献
6.
S. FURUKAWA T. MATSUBARA K. TSUJI K. OKUMURA K. YABUTA 《Scandinavian journal of immunology》1993,37(3):377-380
To clarify the activation of peripheral blood T cells in Kawasaki disease (KD) patients, we investigated whether expression of lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18) and/or intercellular adhesion molecule-1 (ICAM-1, CDS4) on peripheral blood T cells increases during the acute stage. Expression of cellular adhesion molecules was measured using flow cytometry. There was a decrease in the percentage of CD3+ T cells in the bright LFA-1α and LFA-1β population and a concomitant increase in the dim population of LFA-1α and LFA-1β during the acute stage, in comparison with those of the convalescent stage. In addition, we observed no significant differences in ICAM-1 expression during the acute stage compared with that of the convalescent stage. In our view the present data, in conjunction with previous reports on T-cell function during acute KD, suggest that activated T cells are temporarily withdrawn from peripheral circulation during acute KD. 相似文献
7.
SHINICHI HIROSE MASAAKI HIRATA NAOMI AZUMA ZENTARO SHIRAI AKIHISA MITUDOME TEIICHI ODA 《Pediatrics international》1997,39(2):194-200
Carnitine (CAR) plays an important role in the β-oxidation of fatty acids. Less attention, however, has been paid to CAR compared to other nutrients even in total parenteral nutrition (TPN). To examine CAR metabolism during TPN and the effect of simultaneous oral L-CAR supplementation on CAR levels, the blood CAR level was measured in a 3-year-old boy receiving long-term TPN because of short bowel syndrome. Both the total and acyl CAR in the serum were evaluated under various nutritional conditions including oral supplementation of L-CAR. Low CAR concentrations were observed especially when lipid containing TPN regimens were in place. Oral L-CAR supplementation was not sufficient to restore the low CAR levels in the present index patient even when the dose was increased to 120 mg/kg in accordance with the result of the L-CAR absorption test that revealed poor intestinal absorption of this nutrient. Moreover, a markedly low CAR level was measured during the onset of sepsis in the patient, and the blood CAR was depleted when lipid metabolism was activated by lipid loading or sepsis. To date, the late effects of CAR depletion on child growth have not been well examined. It is recommended that the blood CAR level be maintained at normal levels before any prominent manifestations of the deficiency have developed. The intravenous administration of CAR appears to be necessary to supply a sufficient amount of CAR for patients with severe malabsorption. 相似文献
8.
9.
Functional CD86 (B7-2/B70) is predominantly expressed on Langerhans cells in atopic dermatitis 总被引:3,自引:0,他引:3
O.OHKI H.YOKOZEKI I.KATAYAMA T.UMEDA M.AZUMA K.OKUMURA K.NISHIOKA 《The British journal of dermatology》1997,136(6):838-845
Recently, we reported the functional expression of CD86 on cultured human Langerhans cells derived from normal epidermis. In the present study, we investigated the expression and function of co-stimulatory molecules in the pathogenesis of atopic dermatitis. In immunohistochemical analysis, CD80 and/or CD86 were detected on dendritic-shaped cells not only in the epidermis but also in the dermis in the inflammatory lesions of atopic dermatitis (n = 12). CD80 was expressed in only five cases (42%), while CD86 was expressed in all cases (100%). These molecules were not detected in normal control subjects (n = 8). In non-lesional skin of atopic dermatitis (n = 4). CD86 but not CD80 was detected in one case. CD86 was preferentially induced on dendritic-shaped cells in positive patch test sites to Dermatophagoides pteronyssinus or house dust allergen in atopic dermatitis (n = 4). The CD80- or CD86-positive cells were confirmed as Langerhans cells by double immunostaining using anti-CD1a monoclonal antibody. Neither CD86 over that CD80 was detected n keratinocytes. Similar results of the stronger expression of CD86 over that of CD80 were obtained from psoriasis vulgaris (n = 11) and from contact dermatitis (n=7), although CD86 was expressed only in 57% of the contact dermatitis cases. The percentage of Langerhans cells positive for CD86 was higher than for CD80, i.e. 48% compared with 9%, respectively, in the epidermis of lesional skin of atopic dermatitis (n=8). The expression rate of these molecules on Langerhans cells increased in the dermis. To investigate the function of co-stimulatory molecules on Langerhans cells in atopic dermatitis, we conducted an inhibition test with antibodies. Anti-CD86 monoclonal antibody almost completely nhibited T-cell proliferation stimulated with crude extract of D. pteronyssinus in the presence of epidermal cells as antigen-presenting cells, whereas anti-CD80 monoclonal antibody produced less of an inhibitory effect. These data indicate that CD86 expressed on Langerhans cells may play an important part in the pathogenesis of atopic dermatitis.for Investigative Dermatology. Washington, DC (1–5 May 1996). 相似文献
10.
CROCKER B. D.; OKUMURA F.; MCCUAIG D. I.; DENBOROUGH M. A. 《British journal of anaesthesia》1980,52(12):1223-1229
A study of core temperature monitoring during general anaesthesiaindicates that this can be introduced as a routine procedurein order to reduce mortality from malignant hyperpyrexia. Thetemperature profiles of 2410 patients are presented. Both meanrectal and mean oesophageal temperatures decreased during generalanaesthesia. The mean oesophageal temperatures were on average0.6°C less than the mean rectal temperatures during thefirst hour of anaesthesia. An increase in core temperature occurredin nearly 20% of patients. This appeared to be related to aninitially low body temperature. Core temperatures during generalanaesthesia were significantly greater in patients who receivedthe combination of suxamethonium and halothane than in patientsreceiving other drugs. This observation is of theoretical interestand suggests that the increase of temperature in malignant hyperpyrexiamay be an exaggeration of a normal response to these agents.
* Present address: Department of Anaesthesia, National CardiovascularCentre, Osaka, Japan. 相似文献