低分子肝素钙治疗过敏性紫癜及预防肾损害的作用

Objective To investigate the curative effect of low molecular heparin calcium on Henoch-Schoenlein purpura(HSP) and the preventive effect on Henoch-schonlein purpura nephritis.Methods One hundred and three patients with HSP were enrolled in the study and divided randomly into two groups,heparin group(57 cases) and control group(46 cases).Heparin group received low molecular heparin calcisymptom remission time,the incidence of recurrent skin rash were recorded.The contents of D-dipolymer and the three indicators of early renal damage were detected before and after the treatment.Results The remission times of purpura,joint pain and abdominal pain in heparin group[(15.23±3.14) d,(6.80±1.96) d and(6.68±3.42) d]were significantly shorter than those of control group[(17.11±4.79) d,(8.30±2.67)d,(8.59±4.09) d](P ＜0.05).The incidence of recurrent skin rash in heparin group(14.6%) was significantly lower than that of control group(39.1%)(P＜0.01).Compared to control group,the positive rate of D-dipolymer in heparin group was higher(15.8% vs 37.0%),and the urine levels of mALB,β2-MG and NAG were significantly decreased[(12.22±3.92) mg/L,(5.35±0.51) mg/L,(8.12±.65) U/L vs (14.15±5.17) mg/L,(6.54±2.67) mg/L,(10.04±2.60) U/L]during 3 months after treatment(P＜0.01,P ＜0.05).Conclusion Low molecular heparin can shorten the course of HSP and prevent the development of Henoch-Schonlein purpura nephritis.     

兰州大学第一临床医学院2012级儿科学期末考试试卷定量分析

对兰州大学第一临床医学院2012级五年制儿科学期末考试试卷进行了定量分析,结果显示该试卷整体难度适中,但主观题学生得分偏低,综合应用能力不强。因此,教师在今后的教学中应在注重基础知识、基本技能讲解的基础上,加强对学生综合理解和知识运用能力的培养,多引用病例教学法,做到深入浅出、使学生融会贯通。     

孟鲁司特联合舒利迭对支气管哮喘患儿细胞免疫及微量元素的影响

目的探讨孟鲁司特联合舒利迭治疗支气管哮喘患儿的临床疗效及其对患儿细胞免疫及微量元素的影响。方法选择2015年6月至2017年2月凉州医院儿科收治的支气管哮喘患儿60例,随机分为两组,每组30例,对照组患儿接受舒利迭治疗,联合组患者在对照组基础上接受孟鲁司特治疗。评价两组患儿治疗的临床疗效,比较两组患儿治疗前后肺功能、免疫功能及微量元素的变化情况。结果两组患者经治疗1s用力呼出量(FEV1)、用力肺活量(FVC)以及呼吸峰流速(PEF)较治疗前均显著升高(P0.05),且联合组显著高于对照组(P0.05);联合组治疗的总有效率显著高于对照组(P0.05);两组患者较治疗前IFN-γ均显著升高,且联合组显著高于对照组(P0.05),两组患者IL-13较治疗前均显著降低,且联合组显著低于对照组(P0.05);除Cu之外,两组患者经治疗,Ca、Fe、Mg、Cu、Zn等微量元素较治疗前均显著升高(P0.05),且联合组微量元素显著高于对照组(P0.05)。结论孟鲁司特联合舒利迭治疗支气管哮喘患儿疗效显著,可有效改善患儿肺功能及免疫功能,可能有利于促进患儿机体微量元素的平衡。     

维生素D和钙剂治疗营养性佝偻病疗效的Meta分析

目的：采用Meta分析对联合补充钙剂、维生素D与单用维生素D或钙剂治疗佝偻病疗效进行定量评价。方法检索Cochrance Library、Pubmed、Web of science、Scirus、中国期刊全文数据库、中国生物医学文献数据库和万方数据库,检索时间均从建库至2013年3月。获得维生素D和钙剂治疗营养性佝偻病相关的RCT文献。选取血清25-( OH)维生素-D3、磷、ALP作为主要测量指标,选取钙、甲状旁腺素、白蛋白、影像评分作为次要测量指标。采用Review Manage 5．0．2对纳入的RCT文献进行Meta分析。结果共检索到437篇文献,对符合纳入标准的3篇文献(n=218)进入Meta分析。 Meta分析结果显示：(1)血清25-(OH)维生素 D3上升程度：联合治疗组与维生素 D 组 MD =-7．88(95%CI：-12．24~-3．52);联合治疗组与钙剂组MD=-18．32(95%CI：-22．61~-14．04);(2)血清磷上升程度：联合治疗组与维生素D组MD=-0．64(95%CI：-0．86~-0．42);联合治疗组与钙剂组MD=-0．16(95%CI：-0．84~0．51);(3)血清 ALP 下降程度：联合治疗组与维生素 D 组 MD =109．99(95%CI：20．40~199．58);联合治疗组与钙剂组MD=59．89(95%CI：10．09~109．59)。(4)血清钙上升程度：联合治疗组与维生素D组MD=-0．71(95%CI：-0．91~-0．52);影像学评分下降程度：联合治疗组与维生素D组MD=0．68(95%CI：0．42~0．95)。以上指标除联合治疗组与钙剂组对血清磷的上升程度差异无统计学意义外,其余差异均具有统计学意义。结论维生素D联合钙剂长期联合治疗佝偻病的疗效要优于单用维生素D或钙剂。     

感冒通导致小儿急性溶血性贫血1例

1病历资料 患儿李某,男,10岁,主因“发热、流涕2d,酱油色尿1d”急诊入院。入院前2d患儿发热、流涕,精神不振,食欲欠佳,无高热、寒战及腹痛,尿色清亮。家长予口服感冒通2次,早晚各服2片,次日发现患儿全身皮肤巩膜中度黄染,尿为酱油色,伴头昏、全身酸困,四肢疲乏无力,急来兰大一院就诊。否认服用其他药物。     

低分子肝素钙治疗过敏性紫癜及预防肾损害的作用

Objective To investigate the curative effect of low molecular heparin calcium on Henoch-Schoenlein purpura(HSP) and the preventive effect on Henoch-schonlein purpura nephritis.Methods One hundred and three patients with HSP were enrolled in the study and divided randomly into two groups,heparin group(57 cases) and control group(46 cases).Heparin group received low molecular heparin calcisymptom remission time,the incidence of recurrent skin rash were recorded.The contents of D-dipolymer and the three indicators of early renal damage were detected before and after the treatment.Results The remission times of purpura,joint pain and abdominal pain in heparin group[(15.23±3.14) d,(6.80±1.96) d and(6.68±3.42) d]were significantly shorter than those of control group[(17.11±4.79) d,(8.30±2.67)d,(8.59±4.09) d](P ＜0.05).The incidence of recurrent skin rash in heparin group(14.6%) was significantly lower than that of control group(39.1%)(P＜0.01).Compared to control group,the positive rate of D-dipolymer in heparin group was higher(15.8% vs 37.0%),and the urine levels of mALB,β2-MG and NAG were significantly decreased[(12.22±3.92) mg/L,(5.35±0.51) mg/L,(8.12±.65) U/L vs (14.15±5.17) mg/L,(6.54±2.67) mg/L,(10.04±2.60) U/L]during 3 months after treatment(P＜0.01,P ＜0.05).Conclusion Low molecular heparin can shorten the course of HSP and prevent the development of Henoch-Schonlein purpura nephritis.     

低分子肝素钙治疗过敏性紫癜及预防肾损害的作用

Objective To investigate the curative effect of low molecular heparin calcium on Henoch-Schoenlein purpura(HSP) and the preventive effect on Henoch-schonlein purpura nephritis.Methods One hundred and three patients with HSP were enrolled in the study and divided randomly into two groups,heparin group(57 cases) and control group(46 cases).Heparin group received low molecular heparin calcisymptom remission time,the incidence of recurrent skin rash were recorded.The contents of D-dipolymer and the three indicators of early renal damage were detected before and after the treatment.Results The remission times of purpura,joint pain and abdominal pain in heparin group[(15.23±3.14) d,(6.80±1.96) d and(6.68±3.42) d]were significantly shorter than those of control group[(17.11±4.79) d,(8.30±2.67)d,(8.59±4.09) d](P ＜0.05).The incidence of recurrent skin rash in heparin group(14.6%) was significantly lower than that of control group(39.1%)(P＜0.01).Compared to control group,the positive rate of D-dipolymer in heparin group was higher(15.8% vs 37.0%),and the urine levels of mALB,β2-MG and NAG were significantly decreased[(12.22±3.92) mg/L,(5.35±0.51) mg/L,(8.12±.65) U/L vs (14.15±5.17) mg/L,(6.54±2.67) mg/L,(10.04±2.60) U/L]during 3 months after treatment(P＜0.01,P ＜0.05).Conclusion Low molecular heparin can shorten the course of HSP and prevent the development of Henoch-Schonlein purpura nephritis.     

黄葵胶囊联合泼尼松治疗儿童紫癜性肾炎32例

目的:探讨黄葵胶囊联合泼尼松治疗儿童过敏性紫癜性肾炎的临床疗效.方法:将65例符合纳入标准的紫癜性肾炎患儿,分为观察组32例与对照组33例,两组均用泼尼松等西药常规治疗,观察组口服黄葵胶囊,疗程为8周,观察两组治疗前后24小时尿蛋白、尿红细胞计数、β2微球蛋白、血肌酐、尿素氮、总胆固醇及甘油三酯指标的变化情况.结果:治...     

低分子肝素钙治疗过敏性紫癜及预防肾损害的作用

Objective To investigate the curative effect of low molecular heparin calcium on Henoch-Schoenlein purpura(HSP) and the preventive effect on Henoch-schonlein purpura nephritis.Methods One hundred and three patients with HSP were enrolled in the study and divided randomly into two groups,heparin group(57 cases) and control group(46 cases).Heparin group received low molecular heparin calcisymptom remission time,the incidence of recurrent skin rash were recorded.The contents of D-dipolymer and the three indicators of early renal damage were detected before and after the treatment.Results The remission times of purpura,joint pain and abdominal pain in heparin group[(15.23±3.14) d,(6.80±1.96) d and(6.68±3.42) d]were significantly shorter than those of control group[(17.11±4.79) d,(8.30±2.67)d,(8.59±4.09) d](P ＜0.05).The incidence of recurrent skin rash in heparin group(14.6%) was significantly lower than that of control group(39.1%)(P＜0.01).Compared to control group,the positive rate of D-dipolymer in heparin group was higher(15.8% vs 37.0%),and the urine levels of mALB,β2-MG and NAG were significantly decreased[(12.22±3.92) mg/L,(5.35±0.51) mg/L,(8.12±.65) U/L vs (14.15±5.17) mg/L,(6.54±2.67) mg/L,(10.04±2.60) U/L]during 3 months after treatment(P＜0.01,P ＜0.05).Conclusion Low molecular heparin can shorten the course of HSP and prevent the development of Henoch-Schonlein purpura nephritis.     

小儿皮肤蝇蛆病致心脏损害1例报告

蝇蛆病是人畜共患性寄生虫病,人类可偶然受到感染,当蝇蛆穿入人体皮肤可引起皮肤的损害,而幼虫侵入内脏后可引起内脏器官的损害,常易发生误诊。现将我科收治的1例皮肤蝇蛆病致小儿心脏损害报道如下。1病历摘要患儿李某,女,6岁,汉族。因间断发热伴皮肤红肿20d,有幼虫从皮肤爬出,