患者术后疼痛与焦虑情绪的相关性

为探讨术后焦虑情绪和疼痛的相关性，对121例普外患者术后应用临床简明疼痛表（MPQ）和焦虑自评量表（SAS）进行评定，就焦虑情绪和疼痛的关系进行相关性分析，结果显示患者对疼痛的感觉，在情绪和认知上有不同反应，焦虑发生率达40．5％；SAS≤45分者疼痛评定各项得分高于SAS〈45分者，焦虑状态与疼痛反应程度呈显著性正相关，表明患者术后疼痛与焦虑情绪关系密切，疼痛程度有随焦虑情绪增加而增加的趋势。     

糖尿病兔模型视网膜VEGF表达的定位研究

目的研究糖尿病兔动物模型血管内皮细胞生长因子(VEGF)在视网膜中的定位。方法应用四氧嘧啶制备糖尿病兔动物模型,采用免疫荧光、免疫荧光双重标记技术,分别以胶质纤维酸性蛋白(GFAP)抗体、VEGF抗体为一抗;羊抗兔IgG-Cy3、马抗鼠IgG-FITC为二抗进行免疫荧光染色。结果在糖尿病兔动物模型视网膜中,GFAP与VEGF共同表达于视网膜Müller细胞。结论糖尿病兔模型中,视网膜Müller细胞通过表达VEGF发挥促进新生血管形成的作用。     

糖尿病酮症酸中毒患儿氧化应激状况及影响因素分析

Objective To investigate the oxidative stress state in children with diabetic ketoacidosis (DKA),and analyze whether any observed abnormalities were related to metabolic disturbances.Methods Four groups of subjects were studied,comprising with 22 patients with DKA(group 1),18 diabetic children with medium metabolic control,whose glycated hemoglobin(HbAlc) below 9%(group 2),22 children with poorly controlled diabetes,whose Hbal c above 9%(group 3),and 36 healthy control children(group 4).Malondialdehyde(MDA),nitrate oxidase(NO),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),and metabolic parameters such as fasting blood glucose,HbAlc,blood gas analysis,serum ion,renal function of the subjects were measured.Results Mean serum MDA value was significantly higher in group 1 than in group 2(P ＜0.01) and group 4(P ＜0.01),but was not different from that in group 3 (P ＞0.05).Serum levels of NO were significantly higher in group 1,2 and 3 compared with group 4(P＜0.01).Serum levels of GSH-Px were significantly lower in group 1,2 and 3 than in group 4(P＜0.01).There were no significant differences of serum SOD value among the four groups(P＞0.05).Both serum MDA and NO values in the diabetic patients(groups 1 +2 +3) were positively related to HbAlc(r=0.375,P ＜0.01;r=0.250,P ＜0.05),and serum SOD values in the DKA patients were negatively related to HbAlc(r= -0.507,P＜0.05),there were not any significant relationship between the other oxidative markers and metabolic parameters.Conclusion There is an increase of oxidative stress and decrease of antioxygenic ability in DKA children,and these changes tend to correlate more with markers of diabetic imbalance than with parameters of acute metabolic disturbances of DKA.     

澳洲维省糖尿病儿童夏令营见闻

儿童糖尿病夏令营是集娱乐、健身、宣教、治疗为一体的一种集体活动，是一种加强儿童糖尿病管理行之有效的手段。我有幸参加了一期澳大利亚维多利亚省儿童糖尿病夏令营，撰此文将所见所闻与同道分享。     

糖尿病酮症酸中毒患儿氧化应激状况及影响因素分析

Objective To investigate the oxidative stress state in children with diabetic ketoacidosis (DKA),and analyze whether any observed abnormalities were related to metabolic disturbances.Methods Four groups of subjects were studied,comprising with 22 patients with DKA(group 1),18 diabetic children with medium metabolic control,whose glycated hemoglobin(HbAlc) below 9%(group 2),22 children with poorly controlled diabetes,whose Hbal c above 9%(group 3),and 36 healthy control children(group 4).Malondialdehyde(MDA),nitrate oxidase(NO),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),and metabolic parameters such as fasting blood glucose,HbAlc,blood gas analysis,serum ion,renal function of the subjects were measured.Results Mean serum MDA value was significantly higher in group 1 than in group 2(P ＜0.01) and group 4(P ＜0.01),but was not different from that in group 3 (P ＞0.05).Serum levels of NO were significantly higher in group 1,2 and 3 compared with group 4(P＜0.01).Serum levels of GSH-Px were significantly lower in group 1,2 and 3 than in group 4(P＜0.01).There were no significant differences of serum SOD value among the four groups(P＞0.05).Both serum MDA and NO values in the diabetic patients(groups 1 +2 +3) were positively related to HbAlc(r=0.375,P ＜0.01;r=0.250,P ＜0.05),and serum SOD values in the DKA patients were negatively related to HbAlc(r= -0.507,P＜0.05),there were not any significant relationship between the other oxidative markers and metabolic parameters.Conclusion There is an increase of oxidative stress and decrease of antioxygenic ability in DKA children,and these changes tend to correlate more with markers of diabetic imbalance than with parameters of acute metabolic disturbances of DKA.     

三种蒿属蒙药的研究概况

目的：为蒿属蒙药研究提供参考依据。方法：通过收集与查阅近几年铁杆蒿、黑沙蒿及柳蒿芽的研究资料,并整理和归纳其化学成分、定量分析及药理研究状况。结果：共查到了20篇论文,其中有效文献为17篇。结论：铁杆蒿、黑沙蒿及柳蒿芽化学成分研究比较全面,并建立了几种含量测定方法,但其药理研究较少,有待于进一步研究。     

甲巯咪唑治疗儿童甲状腺功能亢进症不良反应的观察

目的 研究甲巯咪唑治疗儿童甲状腺功能亢进症(简称“甲亢”)不良反应发生情况。方法 回顾性分析中国医科大学附属盛京医院2015年1月—2021年5月住院的304例甲亢患儿的临床资料。统计甲巯咪唑治疗相关不良反应的发生情况,探讨常见不良反应的危险因素。结果 304例患儿中,出现甲巯咪唑治疗相关不良反应87例(28.6%),其中男性20例(23%),女性67例(77%)。较常见的不良反应有粒细胞减少(12.8%)、皮疹(11.8%)、丙氨酸氨基转移酶升高(9.5%)及关节疼痛(3.0%),部分患儿可同时或间断出现多种不良反应。粒细胞减少主要出现在用药后3个月内(25/39,64%);丙氨酸氨基转移酶升高主要发生在用药后1个月内(17/29,59%);皮疹主要发生在用药后3个月内(30/36,83%)。对症治疗后上述不良反应大部分可恢复正常。多因素logistic回归分析显示,年龄小、治疗前中性粒细胞绝对计数低是甲巯咪唑治疗后粒细胞减少的危险因素(P<0.05)。结论 甲巯咪唑治疗儿童甲亢不良反应较常见,多发生在用药后3个月内,多数经过对症治疗可缓解。年龄越小,中性粒细胞绝对计数基线值越...     

蒙药胃舒安对束缚-水浸应激致胃溃疡的预防作用及对TGF-β1表达的影响

[目的]评价蒙药胃舒安对束缚-水浸应激所致大鼠胃溃疡的预防作用。[方法]将Wistar实验大鼠,分正常组、给药组和对照组3组,正常组不给药,无束缚-水浸应激压力,对照组给淀粉,给药组灌胃给蒙药胃舒安,给药剂量为0．9～1．3mL／只（82．5g／L）,连续给胃舒安7d后,停食24h,建立3h束缚-水浸应激性胃溃疡模型,取胃,肉眼观察胃黏膜损伤,用Image J图像分析法测定胃黏膜溃疡面积,并进行比较。用酶联免疫吸附测定法检测胃溃疡大鼠血清转化生长因子（TGF-β1）含量并进行比较。[结果]蒙药胃舒安对3h束缚-水浸应激所致大鼠胃溃疡形成有抑制作用。胃舒安组大鼠血清TGF-β1含量明显低于对照组。[结论]蒙药胃舒安对实验大鼠束缚-水浸应激3h所致胃溃疡的形成有显著抑制作用。     

先天性肾上腺皮质增生症诊断及救治(附21例临床分析)

先天性肾上腺皮质增生症（ＣＡＨ）属于肾上腺类固醇激素合成障碍的遗传性疾病。本症由于遗传缺陷致类固醇激素合成途径中一些必需酶缺乏而引起。其中２１羟化酶缺乏占ＣＡＨ的９０％以上，本文２１例均为２１羟化酶完全缺乏和部分缺乏，两者均表现为男性化和男性化伴失盐...