全文获取类型
收费全文 | 6210篇 |
免费 | 444篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 164篇 |
妇产科学 | 103篇 |
基础医学 | 891篇 |
口腔科学 | 114篇 |
临床医学 | 503篇 |
内科学 | 1251篇 |
皮肤病学 | 103篇 |
神经病学 | 750篇 |
特种医学 | 196篇 |
外科学 | 707篇 |
综合类 | 65篇 |
一般理论 | 2篇 |
预防医学 | 589篇 |
眼科学 | 187篇 |
药学 | 419篇 |
中国医学 | 11篇 |
肿瘤学 | 547篇 |
出版年
2022年 | 43篇 |
2021年 | 81篇 |
2020年 | 75篇 |
2019年 | 96篇 |
2018年 | 108篇 |
2017年 | 79篇 |
2016年 | 97篇 |
2015年 | 114篇 |
2014年 | 139篇 |
2013年 | 216篇 |
2012年 | 294篇 |
2011年 | 285篇 |
2010年 | 179篇 |
2009年 | 165篇 |
2008年 | 297篇 |
2007年 | 294篇 |
2006年 | 300篇 |
2005年 | 299篇 |
2004年 | 277篇 |
2003年 | 267篇 |
2002年 | 247篇 |
2001年 | 202篇 |
2000年 | 193篇 |
1999年 | 151篇 |
1998年 | 86篇 |
1997年 | 63篇 |
1996年 | 55篇 |
1995年 | 61篇 |
1994年 | 64篇 |
1993年 | 57篇 |
1992年 | 123篇 |
1991年 | 100篇 |
1990年 | 94篇 |
1989年 | 103篇 |
1988年 | 79篇 |
1987年 | 94篇 |
1986年 | 97篇 |
1985年 | 83篇 |
1984年 | 62篇 |
1983年 | 70篇 |
1982年 | 57篇 |
1981年 | 51篇 |
1979年 | 72篇 |
1978年 | 47篇 |
1977年 | 44篇 |
1976年 | 54篇 |
1975年 | 38篇 |
1974年 | 51篇 |
1973年 | 42篇 |
1972年 | 42篇 |
排序方式: 共有6660条查询结果,搜索用时 15 毫秒
1.
2.
Can EGFR mutation status be reliably determined in pre‐operative needle biopsies from adenocarcinomas of the lung?
下载免费PDF全文
![点击此处可从《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Kim Hein Lindahl Flemming Brandt Sørensen Søren Peter Jonstrup Karen Ege Olsen Siegfried Loeschke 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(4):289-297
The identification of EGFR mutations in non‐small‐cell lung cancer is important for selecting patients, who may benefit from treatment with EGFR tyrosine kinase inhibitors. The analysis is usually performed on cytological aspirates and/or histological needle biopsies, representing a small fraction of the tumour volume. The aim of the present investigation was to evaluate the diagnostic performance of this molecular test. We retrospectively included 201 patients with primary adenocarcinoma of the lung. EGFR mutation status (exon 19 deletions and exon 21 L858R point mutation) was evaluated on both pre‐operative biopsies (131 histological and 70 cytological) and on the surgical specimens, using PCR. Samples with low tumour cell fraction were assigned to laser micro‐dissection (LMD). We found nine (4.5%) patients with EGFR mutation in the lung tumour resections, but failed to identify mutation in one of the corresponding pre‐operative, cytological specimens. Several (18.4%) analyses of the pre‐operative biopsies were inconclusive, especially in case of biopsies undergoing LMD and regarding exon 21 analysis. Discrepancy of mutation status in one patient may reflect intra‐tumoural heterogeneity or technical issues. Moreover, several inconclusive results in the diagnostic biopsies reveal that attention must be paid on the suitability of pre‐operative biopsies for EGFR mutation analysis. 相似文献
3.
4.
5.
6.
7.
8.
9.
Acute hemodynamic effects of piroximone (MDL 19,205) in patients with moderate congestive heart failure: comparison with sodium nitroprusside 总被引:1,自引:0,他引:1
R Arbogast C M Brandt J L Fincker P J Schechter 《Journal of cardiovascular pharmacology》1986,8(1):82-89
Piroximone (MDL 19,205), a new imidazolone derivative, was given intravenously to 14 patients with congestive heart failure (NYHA class II-III), while under constant daily doses of digitalis and diuretics. In the first 3 patients, we determined the dose safely eliciting a favorable hemodynamic response. The subsequent 11 patients received 1 mg/kg of piroximone intravenously, and the hemodynamic effects were compared with those of sodium nitroprusside (SN) at a dose-lowering mean blood pressure by 10-20 mm Hg. Piroximone increased heart rate (13.2 +/- 2.0 beats/min, mean +/- SEM) and lowered mean arterial pressure (9 +/- 2.3 mm Hg). Both agents reduced similarly wedge pressure (6.5 +/- 2.9 and 9 +/- 2.9 mm Hg, respectively, for SN and piroximone) and total peripheral resistance. Cardiac index was increased less by SN (15%) than piroximone (48%) (p less than 0.001), and stroke work index significantly enhanced only by piroximone (p less than 0.001). The changes in loading conditions induced by the two agents being similar, it is likely that piroximone not only acts by peripheral vasodilation, but also possesses positive inotropic properties. Myocardial oxygen demand, assessed indirectly by tension-time index, was not affected by piroximone. Thus, piroximone appears to combine well-balanced vasodilator and inotropic properties which make this new agent potentially very useful for the management of congestive heart failure. 相似文献
10.
Dr. S. Besier T.M. Bingold F. Walcher K. Engels B. Spellerberg V. Brade C. Brandt 《Der Chirurg》2007,78(12):1148-1151
Streptococcus agalactiae, known as a pathogen that causes meningitis and septicemia in neonates, emerges as an invasive organism in nonpregnant adults. This case report describes the fulminant course of a necrotizing fasciitis (NF) with streptococcal toxic shock-like syndrome (STSS) in a 76-year-old diabetic patient caused by S. agalactiae, serotype V. Chronic diseases and immunodeficiency are considered to be risk factors for the acquisition of group B streptococcal disease. Since early surgical treatment in conjunction with antimicrobial and intensive care therapy is critical for the outcome of patients with NF and/or STSS, clinicians should be aware of invasive S. agalactiae infections in adults with subcutaneous emphysema. 相似文献