全文获取类型
收费全文 | 286篇 |
免费 | 6篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 20篇 |
妇产科学 | 1篇 |
基础医学 | 21篇 |
口腔科学 | 13篇 |
临床医学 | 26篇 |
内科学 | 83篇 |
皮肤病学 | 3篇 |
神经病学 | 6篇 |
特种医学 | 45篇 |
外科学 | 46篇 |
综合类 | 1篇 |
预防医学 | 17篇 |
药学 | 10篇 |
肿瘤学 | 5篇 |
出版年
2019年 | 2篇 |
2015年 | 3篇 |
2013年 | 4篇 |
2012年 | 2篇 |
2011年 | 5篇 |
2010年 | 2篇 |
2009年 | 5篇 |
2008年 | 5篇 |
2007年 | 8篇 |
2006年 | 3篇 |
2005年 | 7篇 |
2004年 | 4篇 |
2003年 | 6篇 |
2002年 | 5篇 |
2001年 | 5篇 |
2000年 | 9篇 |
1999年 | 6篇 |
1998年 | 10篇 |
1997年 | 11篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 7篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 6篇 |
1990年 | 10篇 |
1989年 | 12篇 |
1988年 | 17篇 |
1987年 | 11篇 |
1986年 | 16篇 |
1985年 | 13篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1975年 | 12篇 |
1974年 | 7篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1971年 | 5篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 5篇 |
1967年 | 5篇 |
1966年 | 2篇 |
1965年 | 1篇 |
排序方式: 共有298条查询结果,搜索用时 78 毫秒
1.
2.
A. K. Goenjian L. M. Najarian R. S. Pynoos A. M. Steinberg P. Petrosian S. Setrakyan L. A. Fairbanks 《Acta psychiatrica Scandinavica》1994,90(3):214-221
This study evaluated the severity and symptom profile of posttraumatic stress reactions of 202 adults exposed in 1988 to political violence in Azerbaijan and/or the earthquake in Armenia. High rates of severe posttraumatic stress reactions were found among the most highly exposed individuals, irrespective of the type of trauma. There was no difference in symptom profile for subjects exposed to earthquake versus violence. These similarities in severity and symptom profile may be attributable to common features of the exposures, which included experiencing life-threat and witnessing injury, mutilation and death. Recent prior exposure to violence contributed to the severity of reaction to the earthquake. The high rates of chronic and severe posttraumatic stress reactions in Armenia constitute a major public mental health problem. 相似文献
3.
Gene conversion is a likely cause of mutation in PKD1 总被引:3,自引:0,他引:3
Watnick TJ; Gandolph MA; Weber H; Neumann HP; Germino GG 《Human molecular genetics》1998,7(8):1239-1243
Approximately 70% of the gene responsible for the most common form of
autosomal dominant polycystic kidney disease ( PKD1 ) is replicated in
several highly homologous copies located more proximally on chromosome 16.
We recently have described a novel technique for mutation detection in the
duplicated region of PKD1 that circumvents the difficulties posed by these
homologs. We have used this method to identify two patients with a nearly
identical cluster of base pair substitutions in exon 23. Since pseudogenes
are known to be reservoirs for mutation via gene conversion events for a
number of other diseases, we decided to test whether these sequence
differences in PKD1 could have arisen as a result of this mechanism. Using
changes in restriction digest patterns, we were able to show that these
sequence substitutions are also present in N23HA, a rodent-human somatic
cell hybrid that contains only the PKD1 homologs. Moreover, these changes
were also detected in total DNA from several affected and unaffected
individuals that did not harbor this mutation in their PKD1 gene copy. This
is the first example of gene conversion in PKD1 , and our findings
highlight the importance of using gene-specific reagents in defining PKD1
mutations.
相似文献
4.
Sixty-seven patients with angiographically-confirmed coronary heart disease (CHD) were investigated. Three patterns of thyroid hormone (T3 and T4) response to exercise were identified: rising, falling and unchanged levels. Coronary patients with rising T3 levels in response to exercise typically showed smaller left-ventricular ejection values as compared to those patients whose T3 levels declined. Coronary patients with low baseline T3 tended to have elevated left-ventricular end diastolic pressure after exercise. The demonstrated changes in plasma thyroid hormone levels are related to the severity of coronary disease and can be "protective" or, on the contrary, aggravating. Because of smaller biologic activity, T4 does not basically affect clinical manifestations of CHD. 相似文献
5.
Modulation of immunoglobulin production and cytokine mRNA expression in peripheral blood mononuclear cells by intravenous immunoglobulin 总被引:1,自引:0,他引:1
Mieko Toyoda Xiaoming Zhang Anna Petrosian Odette A. Galera Sue-Jane Wang Stanley C. Jordan 《Journal of clinical immunology》1994,14(3):178-189
Intravenous immunoglobulin (IVIG) has the potential to regulate Ig production, but the mechanism(s) responsible for this effect is unknown. In experiments reported here, we examined the ability of IVIG to regulate Ig production in human peripheral blood mononuclear cells (PBMCs) stimulated with pokeweed mitogen (PWM). IVIG (2–10 mg/ml) showed a potent (80–85%) inhibition of PWM-stimulated IgG, IgM, and IgA production. To determine more precisely how IVIG mediated the inhibition of Ig production, we studied Ig promoting cytokine gene expression after PWM stimulation with or without IVIG (2 and 10 mg/ml) using dot-blot techniques. RNA was isolated from PBMCs at predetermined time points and probed with cDNAs specific for human cytokines (IL-1-, IL-2, IL-2R, IL-4, IL-5, IL-6, -IFN, and TNF-). IL-6 mRNA accumulation was maximal at 4.5 hr post-PWM stimulation and was inhibited 64–75% when IVIG (10 mg/ml) was present. -IFN mRNA levels peaked at 72 hr poststimulation and were also 68–75% inhibited by IVIG. IL-2 mRNA levels peaked at 4.5 hr and were 23–46% inhibited by IVIG. The inhibitory effect of IVIG on production of these cytokines (IL-6 and -IFN) was also observed at the protein level in sonicated PBMCs after incubation with PWM and IVIG. The mRNA levels for other cytokines were not or only minimally inhibited by IVIG. Addition of IL-6, -IFN, or IL-2 partially restored Ig production in IVIG-treated PWM-stimulated cultures, suggesting that inhibition of other cytokines or another mechanism(s) independent of cytokine inhibition might also be involved, although inhibition of IL-6, -IFN, and IL-2 may be one of the critical factors in the suppression of Ig production by IVIG. 相似文献
6.
In respect of other age groups the number of elderly and old patients constantly increases and today it constitutes the 5th part of population in many countries. That's why the "ageing" of tuberculosis is a natural process. The urgency of the problem of pulmonary tuberculosis in the elderly and senile age is determined by the high epidemiologic indices of disease incidence, by the difficulties of diagnosis and clinical course and by the peculiarities of rehabilitative measures in the patients of these age groups. The article deals with some medical aspects of the hospital period of rehabilitation in the patients with pulmonary tuberculosis. These aspects concern the new methodological approaches to the evaluation of therapeutic efficiency and to the formation of patient populations of the elderly and senile age, who need the restorative treatment under conditions of the specialized rehabilitative department. 相似文献
7.
8.
9.
BACKGROUND & AIMS: Shwachman syndrome is an inherited condition with multisystemic abnormalities, including exocrine pancreatic dysfunction. The aim of this study was to evaluate the occurrence and progression of features in a large cohort of patients. METHODS: Clinical records of 25 patients with Shwachman syndrome were reviewed. RESULTS: Mean birth weight (2.92 +/- 0.51 kg) was at the 25th percentile. However, by 6 months of age, mean heights and weights were less than the 5th percentile. After 6 months of age, growth velocity was normal. Severe fat maldigestion due to pancreatic insufficiency was present in early life (fecal fat, 26% +/- 17% of fat intake; age, < 2 years). Serial assessment of exocrine pancreatic function showed persistent deficits of enzyme secretion, but 45% of patients showed moderate age-related improvements leading to pancreatic sufficiency. Neutropenia was the most common hematologic abnormality (88%), but leukopenia, thrombocytopenia, and anemia were also frequently encountered. Patients with hypoplasia of all three bone marrow cellular lines (n = 11) had the worst prognosis; 5 patients died, 2 of sepsis and 3 of acute myelogenous leukemia. Other findings included hepatomegaly and/or abnormal liver function test results and skeletal abnormalities. CONCLUSIONS: A wide and varied spectrum of phenotypic abnormalities among patients with Shwachman syndrome is described. Pancreatic acinar dysfunction is an invariable abnormality. Patients with severe bone marrow involvement may have a guarded prognosis. (Gastroenterology 1996 Dec;111(6):1593-602) 相似文献
10.