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G Ferrandina G Scambia P Benedetti Panici G Almadori G Paludetti G Cadoni M Distefano M Maurizi S Mancuso 《Cancer letters》1992,67(2-3):133-138
Using an immunoradiometric assay, Cathepsin D (Cath D) levels were measured in the cytosol of 23 normal and 39 neoplastic human laryngeal tissues. Scattered Cath D levels (from 2.2 to 17.8 pM/mg protein; median = 7.6) were found in normal mucosa specimens. Cath D concentrations range from 2.0 to 29.3 pM/mg protein (median = 8.5) in laryngeal tumors. When a comparison between Cath D levels in normal and neoplastic tissue specimens from the same patient was done, Cath D levels were significantly higher in laryngeal cancers than in their normal counterparts (P = 0.03). No correlation with clinico-pathological parameters and steroid hormone and epidermal growth factor receptor status was found. Further studies should investigate whether the production of Cath D by laryngeal tumors could have a clinical relevance for this neoplasia. 相似文献
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Comparison of interstitial brachytherapy and surgery as primary treatments for nasal vestibule carcinomas 下载免费PDF全文
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Longobardi Ylenia Parrilla Claudio Di Cintio Giovanni De Corso Eugenio Marenda Maria Elisabetta Mari Giorgia Paludetti Gaetano D’Alatri Lucia Passali Giulio Cesare 《European archives of oto-rhino-laryngology》2020,277(7):2095-2105
European Archives of Oto-Rhino-Laryngology - We aim to propose a new protocol for olfaction rehabilitation after total laryngectomy based on training of sensory perception levels using the Nasal... 相似文献
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G Almadori L Bastianini F Bistoni G Paludetti M Rosignoli 《International journal of pediatric otorhinolaryngology》1988,15(2):157-162
Surface and 'core' tonsillar specimens were collected from 60 children, between 2 and 14 years of age, suffering from recurrent tonsillitis, in order to establish the reliability of surface tonsillar swabbing technique and to define the most frequently involved aerobic and anaerobic microorganisms. From the qualitative point of view, the same mixed aerobic and anaerobic flora were obtained in both samples thus demonstrating the reliability of the surface swabbing technique. From the quantitative point of view, 187 microorganisms, 129 (69.2%) aerobes and 58 (30.8%) anaerobes were isolated from surface cultures while 184, 109 (59.2%) aerobes and 75 (40.8%) anaerobes from the core cultures, thus demonstrating a greater number of anaerobes in the core of the tonsil. The most common isolated aerobic microorganisms were the alpha- and beta-hemolytic Streptococci, the Neisseriae and the Staphylococcus aureus; the predominant anaerobic ones were the Fusobacterium nucleatum, the Bacteroides sp. and the Veillonella parvula. The isolated staphylococcus aureus and the bacteroides sp. were all beta-lactamase producers. 相似文献
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Lombardi CP Raffaelli M D'alatri L De Crea C Marchese MR Maccora D Paludetti G Bellantone R 《World journal of surgery》2008,32(5):693-700
Background Voice and swallowing symptoms are frequently reported after thyroidectomy even in absence of objective voice alterations.
We evaluated the influence of the video-assisted approach on voice and swallowing outcome of thyroidectomy.
Methods Sixty-five patients undergoing total thyroidectomy (TT) were recruited. Eligibility criteria were: nodule size ≤30 mm, thyroid
volume ≤30 ml, no previous neck surgery. Exclusion criteria were: younger than aged 18 years and older than aged 75 years,
vocal fold paralysis, history of voice, laryngeal or pulmonary diseases, malignancy other than papillary thyroid carcinoma.
Patients were randomized for video-assisted (VAT) or conventional (CT) thyroidectomy. Videostrobolaryngoscopy (VSL), acoustic
voice analysis (AVA), and maximum phonation time (MPT) evaluation were performed preoperatively and 3 months after TT. Subjective
evaluation of voice (voice impairment score = VIS) and swallowing (swallowing impairment score = SIS) were obtained preoperatively,
1 week, 1 month, and 3 months after TT.
Results Fifty-three patients completed the postoperative evaluation: 29 in the VAT group, and 24 in the CT group. No laryngeal nerves
injury was shown at postoperative VSL. Mean postoperative MPT, F
0, F
low, F
high, and the number of semitones were significantly reduced in the CT group but not in the VAT group. Mean VIS 3 months after
surgery was significantly higher than preoperatively in CT group but not in the VAT group. Mean SIS was significantly decreased
1 and 3 months after VAT but not after CT.
Conclusions The incidence and the severity of early voice and swallowing postthyroidectomy symptoms are significantly reduced in patients
who undergo VAT compared with conventional surgery.
Presented at the ISW2007—IAES free paper session, Montreal, Canada, August 26–30, 2007. 相似文献
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G. Scambia L. Catozzi P. Benedetti Panici G. Ferrandina G. Almadori G. Paludetti G. Cadoni M. Distefano A. Piffanelli S. Mancuso et al. 《British journal of cancer》1994,69(6):995-999
Western blotting analysis of the p21 ras oncoprotein was performed in seven normal laryngeal mucosa specimens and 43 primary laryngeal cancers. Varying p21 levels, expressed as optical density (OD), were found in normal mucosa (median 1.94 OD, range 0.90-2.17 OD) and in primary laryngeal tumours (median 1.74 OD, range 0.30-6.37 OD). When p21 expression in laryngeal cancer was compared with the normal counterpart, higher levels were found in neoplastic than in normal laryngeal tissue (median 2.54 OD, range 1.76-6.37 OD, vs median 1.94 OD, range 0.90-2.17 OD) (P = 0.023). Immunohistochemical analysis demonstrated that most of the tumour cells (more than 70%) were immunostained while the stromal component was unreactive. No correlation between p21 expression and tumour location, stage and histopathological grade was observed. The correlation between ras p21 protein expression and epidermal growth factor receptor (EGFR) levels was also investigated. EGFR-positive cases did not show any difference in p21 expression with respect to EGFR-negative cases (median 1.52 OD, range 0.30-6.37 OD, vs median 1.84 OD, range 0.93-3.71 OD). Our findings suggest that overexpression of p21 protein is associated with a malignant phenotype in laryngeal cancer. Further studies should be undertaken to evaluate whether the assessment of p21 protein expression may have clinical significance in laryngeal cancer. 相似文献