全文获取类型
收费全文 | 1652篇 |
免费 | 141篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 50篇 |
儿科学 | 83篇 |
妇产科学 | 24篇 |
基础医学 | 193篇 |
口腔科学 | 37篇 |
临床医学 | 241篇 |
内科学 | 397篇 |
皮肤病学 | 10篇 |
神经病学 | 76篇 |
特种医学 | 161篇 |
外科学 | 195篇 |
综合类 | 31篇 |
一般理论 | 1篇 |
预防医学 | 134篇 |
眼科学 | 51篇 |
药学 | 70篇 |
中国医学 | 4篇 |
肿瘤学 | 49篇 |
出版年
2022年 | 10篇 |
2021年 | 16篇 |
2020年 | 21篇 |
2019年 | 27篇 |
2018年 | 18篇 |
2017年 | 15篇 |
2016年 | 19篇 |
2015年 | 19篇 |
2014年 | 38篇 |
2013年 | 47篇 |
2012年 | 48篇 |
2011年 | 44篇 |
2010年 | 41篇 |
2009年 | 44篇 |
2008年 | 44篇 |
2007年 | 58篇 |
2006年 | 58篇 |
2005年 | 63篇 |
2004年 | 41篇 |
2003年 | 50篇 |
2002年 | 42篇 |
2001年 | 46篇 |
2000年 | 43篇 |
1999年 | 56篇 |
1998年 | 52篇 |
1997年 | 69篇 |
1996年 | 51篇 |
1995年 | 45篇 |
1994年 | 41篇 |
1993年 | 38篇 |
1992年 | 36篇 |
1991年 | 45篇 |
1990年 | 38篇 |
1989年 | 42篇 |
1988年 | 41篇 |
1987年 | 39篇 |
1986年 | 49篇 |
1985年 | 46篇 |
1984年 | 28篇 |
1983年 | 23篇 |
1982年 | 19篇 |
1981年 | 17篇 |
1980年 | 20篇 |
1979年 | 19篇 |
1978年 | 18篇 |
1977年 | 17篇 |
1976年 | 12篇 |
1975年 | 11篇 |
1971年 | 12篇 |
1967年 | 10篇 |
排序方式: 共有1807条查询结果,搜索用时 31 毫秒
1.
2.
P. A. Milligan P. E. McGill C. W. Howden A. W. Kelman B. Whiting 《European journal of clinical pharmacology》1993,45(6):507-512
Summary A randomised crossover study was performed in subjects with rheumatoid arthritis (or other arthropathies) to investigate if any alteration in the steady pharmacokinetics of the NSAID piroxicam (a drug which is extensively metabolised via cytochrome P450) or its major metabolites occurred as a result of coadministering either cimetidine or nizatidine.Twelve females and 2 males with mean age, weight, and albumin concentrations of 58 years, 61 kg, and 40 g·L–1 respectively, completed the study. Comparisons were made between the following parameters: plasma piroxicam AUCs [AUC0-24(P)], plasma 5-hydroxypiroxicam AUCs [AUC0-24(5-OHP)], the ratio of these i.e. AUC0-24(5-OHP):AUC0-24(p), the % piroxicam daily dose excreted in urine as 5-hydroxypiroxicam (before and after glucuronidase incubation); and the mean of the steady state trough piroxicam, and 5-hydroxypiroxicam concentrations (obtained during each study phase in addition to the wash-out period).A statistically significant difference as a result of initiating either cimetidine or nizatidine was obtained only for the ratio AUC0-23(5-OHP):AUC0-24(P). This was indicative of a weak potential to inhibit piroxicam hydroxylation.No clinically significant alteration in the steady state pharmacokinetics of piroxicam occurred in these subjects as a result of cimetidine or nizatidine coadministration. Consequently it is unlikely that any adverse events would arise from these combinations. 相似文献
3.
Intracranial circulation: pulse-sequence considerations in three- dimensional (volume) MR angiography 总被引:2,自引:0,他引:2
The technique and feasibility of magnetic resonance (MR) angiography of intracranial vessels were studied in 35 healthy volunteers. Variations in image orientation, repetition time (TR), and flip angle were evaluated to determine their effects on flow-related enhancement. Gradient modifications--including echo time (TE), motion compensation, bandwidth, and field of view--were also studied in an effort to reduce motion-induced phase shifts. Results indicated that a FISP (fast imaging with steady precession) sequence with a TR of 50 msec, TE of 15 msec, velocity compensation in the read and section-select directions, acceleration compensation in the read direction, anisotropic volume, and a 1.25-mm partition thickness produced three-dimensional angiographic MR images that were accurate and reproducible in the depiction of the major intracranial vessels. Difficulties with field of view, persistent signal void secondary to higher-order motion, and spatial resolution remain major problems requiring additional study. 相似文献
4.
Williamson Kathleen A.; Hever Ann M.; Rainger Joe; Rogers R. Curtis; Magee Alex; Fiedler Zdenek; Keng Wee Teik; Sharkey Freddie H.; McGill Niolette; Hill Clare J.; Schneider Adele; Messina Mario; Turnpenny Peter D.; Fantes Judy A.; van Heyningen Veronica; FitzPatrick David R. 《Human molecular genetics》2006,15(12):2030
Table 1 相似文献
5.
Paediatric dacryocystorhinostomy 总被引:1,自引:0,他引:1
KN Hakin FRCS FRCOphth TJ Sullivan FRACO FRACS A Sharma FCOphth † RAN Welham FRCS FCOphth † 《Clinical & experimental ophthalmology》1994,22(4):231-235
Of 258 cases of dacryocystorhinostomy performed on children in the period September 1981 to September 1991, 130 were for simple, unresolved congenital nasolacrimal duct obstruction. Other indications for surgery included punctal agenesis, lacrimal fistula, post-traumatic and post-inflammatory canalicular obstruction. Of 177 children without canalicular pathology, 171 (96%) were relieved of symptoms with one operation, without canalicular intubation. Of 81 cases with canalicular disease, 55 of 70 (79%) who underwent DCR plus canalicular intubation, and 10 of 11 who underwent DCR plus Lester-Jones tube, were substantially improved with one operation. No child required peroperative or postoperative blood transfusion. Dacryocystorhinostomy in childhood, in experienced surgical hands, is a safe procedure, achieving relief of symptoms in most cases, particularly in the absence of canalicular disease. 相似文献
6.
7.
8.
9.
The effects of intramuscular injections of succinylcholine with or without atropine on heart rate and rhythm were studied in 50 unpremedicated children 6-18 months of age. All had anesthesia induced with N2O-O2 and halothane 2% by face mask. Sixty seconds later, one of four study drugs or drug combinations was injected into the deltoid muscle of patients in groups 1-4. Following injection, halothane concentration was reduced to 1%, and ventilation was controlled. Patients given atropine only (0.02 mg/kg), succinylcholine only (4 mg/kg), or a combination of both (4 mg/kg succinylcholine plus 0.02 mg/kg atropine) showed transient increases in heart rate to 106 +/- 7.5%, 113 +/- 11.8%, and 109 +/- 10.1% (mean +/- SD) of control, followed by a decrease to 78 +/- 6.7%, 79 +/- 9.4%, and 80 +/- 10.5%, respectively, in 2-3 min after injection. Patients given a combination of succinylcholine (4 mg/kg) plus a higher dose of atropine (0.03 mg/kg) also had a transient increase in heart rate to 107 +/- 7.5%, followed by a decrease to 82 +/- 11.8% 2 min after injection. However, this group differed from the other three groups in presenting a second, prolonged increase in heart rate to 115 +/- 9.0% of preinjection levels. Patients in group 5 (controls) received no injections. Their heart rate decreased to 76 +/- 10.78% of preinduction level within 90 sec of induction, and remained unchanged thereafter. We conclude that succinylcholine (4 mg/kg) can be used intramuscularly with or without atropine (0.02 mg/kg) in lightly anesthetized young children without producing severe bradycardia.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
10.
Early Determinants of Adult Metabolic Regulation: Effects of Infant Nutrition on Adult Lipid and Lipoprotein Metabolism 总被引:4,自引:0,他引:4